Výsledky vyhledávání - "Kerri L. Webster"

Design and preparation of serine–threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures. Part 3 †

Autor: Amit P. Mehrotra, Michael E. O'Donnell, David Gani, Antony B. Maude, Kerri L. Webster

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :1673-1695

Nodularin and microcystins are complex natural cyclic isopeptidic hepatotoxins that serve as subnanomolar inhibitors of the eukaryotic serine–threonine protein phosphatases PP1 and PP2A, enzymes that are intimately involved in controlling cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::095c40d7bc0895eb315e8f5eb0d4e717
https://doi.org/10.1039/b100401h

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Comparison of solution-phase and solid-phase syntheses of a restrained proline-containing analogue of the nodularin macrocycle

Autor: David Gani, Trevor J. Rutherford, Kerri L. Webster

Publikováno v: Tetrahedron Letters. 38:5713-5716

The solution-phase synthesis of a restrained (2 S )-proline-containing analogue of the nodularin macrocycle, cyclo -[ β -Ala-(2 R )-Glu(α-OMe)-γ-(2 R )-Asp(α-OMe)-β-(2 S )-Phe-], is described and compared to two solid-phase syntheses of the same

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::201af87aaeba4d529ff08d0dbbd3ec10
https://doi.org/10.1016/s0040-4039(97)01253-7

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Design and preparation of serine–threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures: Part 1. Evaluation of key inhibitory features and synthesis of a rationally stripped-down nodularin macrocycle

Autor: Kerri L. Webster, David Gani, Amit P. Mehrotra

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2495-2512

The natural nodularin and microcystin toxins are powerful but non-selective inhibitors of the ubiquitous and structurally related eukaryotic Ser-Thr protein phosphatases, PP1 and PP2A, enzymes that are intimately involved in controlling cellular meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afb523cb465a27b3e39e340af40ccc9d
https://doi.org/10.1039/a702407j

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ChemInform Abstract: Design and Preparation of Serine-Threonine Protein Phosphatase Inhibitors Based Upon the Nodularin and Microcystin Toxin Structures. Part 1. Evaluation of Key Inhibitory Features and Synthesis of a Rationally Stripped-Down Nodularin M

Autor: Amit P. Mehrotra, David Gani, Kerri L. Webster

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da6db56ed08e834df7fb289930bb741a
https://doi.org/10.1002/chin.199751215

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ChemInform Abstract: Design and Preparation of Serine-Threonine Protein Phosphatase Inhibitors Based upon the Nodularin and Microcystin Toxin Structures. Part 3

Autor: Kerri L. Webster, Michael E. O'Donnell, Amit P. Mehrotra, David Gani, Antony B. Maude

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d0dc329b14f80b5b49befe471fd4277
https://doi.org/10.1002/chin.200146189

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