Investigating Two Modes of Cancer-Associated Antigen Heterogeneity in an Agent-Based Model of Chimeric Antigen Receptor T-Cell Therapy

Autor: Tina Giorgadze, Henning Fischel, Ansel Tessier, Kerri-Ann Norton

Publikováno v: Cells, Vol 11, Iss 19, p 3165 (2022)

Chimeric antigen receptor (CAR) T-cell therapy has been successful in treating liquid tumors but has had limited success in solid tumors. This work examines unanswered questions regarding CAR T-cell therapy using computational modeling, such as, what

Externí odkaz: https://doaj.org/article/517d56afbd854c0aa1e2ace30cd46ebd

Automated reconstruction algorithm for identification of 3D architectures of cribriform ductal carcinoma in situ.

Autor: Kerri-Ann Norton, Sameera Namazi, Nicola Barnard, Mariko Fujibayashi, Gyan Bhanot, Shridar Ganesan, Hitoshi Iyatomi, Koichi Ogawa, Troy Shinbrot

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44011 (2012)

Ductal carcinoma in situ (DCIS) is a pre-invasive carcinoma of the breast that exhibits several distinct morphologies but the link between morphology and patient outcome is not clear. We hypothesize that different mechanisms of growth may still resul

Externí odkaz: https://doaj.org/article/4d62e8ea0b0b4851899404597dfb2bc8

Simulating an Immune Response with a Combined Agent-Based Model of a Triple-Negative Breast Cancer Tumor and Vascular Network

Autor: Kerri-Ann Norton, Michael Ventoso

Publikováno v: BIBM

Cytotoxic T-cells (CTLs) are one mechanism the immune system employs to eliminate cancer cells. In this study, we expand upon a previous 3-dimensional agent-based model of triple-negative breast cancer to include an immuno-therapy in the form of a CT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56e093db1a1fcd9a9048ec951a4b2068
https://doi.org/10.1109/bibm49941.2020.9313463

Dynamic Changes in Microvascular Flow Conductivity and Perfusion After Myocardial Infarction Shown by Image-Based Modeling

Autor: Alicia G. Arroyo, Polyxeni Gkontra, Andres Santos, Aleksander S. Popel, Wahbi K. El-Bouri, Stephen J. Payne, Kerri-Ann Norton

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Repisalud
Instituto de Salud Carlos III (ISCIII)
Journal of the American Heart Association, ISSN 2047-9980, 2019, Vol. 8, No. 7
Archivo Digital UPM
Universidad Politécnica de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname

31 p.-5 fig.-4 tab.-6 fig. supl.-1 tab. supl.
Background-Microcirculation is a decisive factor in tissue reperfusion inadequacy following myocardial infarction (MI).Nonetheless, experimental assessment of blood flow in microcirculation remains a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec177469a2177e774bec8fe1663b310a
https://pubmed.ncbi.nlm.nih.gov/30897998

Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis

Autor: Aleksander S. Popel, Cristina Clemente, Alicia G. Arroyo, Kerri-Ann Norton, Borja Ibanez, Andres Santos, Polyxeni Gkontra, Jaume Aguero, Magdalena M. Żak

Publikováno v: Scientific Reports
Scientific Reports, ISSN 2045-2322, 2018-01, Vol. 8, No. 1854
Archivo Digital UPM
instname
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)

The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b260d6e7007690026cfb511182fd5b
http://europepmc.org/articles/PMC5789835