Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineering

Autor: Kerr Ding, Michael Chin, Yunlong Zhao, Wei Huang, Binh Khanh Mai, Huanan Wang, Peng Liu, Yang Yang, Yunan Luo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract The effective design of combinatorial libraries to balance fitness and diversity facilitates the engineering of useful enzyme functions, particularly those that are poorly characterized or unknown in biology. We introduce MODIFY, a machine l

Externí odkaz: https://doaj.org/article/92b32ea6bf69489796dd38f7cbfdad29

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3-Chloro,4-methoxyfendiline is a potent GABA(B) receptor potentiator in rat neocortical slices.

Autor: Ong J; Department of Anaesthesia and Intensive Care, The University of Adelaide, Adelaide, South Australia 5005, Australia. jennifer.ong@adelaide.edu.au, Parker DA, Marino V, Kerr DI, Puspawati NM, Prager RH

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2005 Jan 10; Vol. 507 (1-3), pp. 35-42. Date of Electronic Publication: 2004 Dec 15.

Potentiation of metabotropic GABAB receptors by L-amino acids and dipeptides in rat neocortex.

Autor: Kerr DI; Department of Anaesthesia and Intensive Care, The University of Adelaide, South Australia, Adelaide, Australia, Ong J

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2003 May 09; Vol. 468 (2), pp. 103-8.