Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

Autor: Dhandapani, Rahul, Neri, Marilisa, Bernhard, Mario, Brzak, Irena, Schweizer, Tatjana, Rudin, Stefan, Joller, Stefanie, Berth, Ramon, Kernen, Jasmin, Neuhaus, Anna, Waldt, Annick, Cuttat, Rachel, Naumann, Ulrike, Keller, Caroline Gubser, Roma, Guglielmo, Feuerbach, Dominik, Shimshek, Derya R., Neumann, Ulf, Gasparini, Fabrizio, Galimberti, Ivan

Publikováno v: In Cell Reports 31 May 2022 39(9)

A transcribed enhancer dictates mesendoderm specification in pluripotency

Autor: Ching-Chia Ting, Jasmin Kernen, Frédéric Burdet, Samir Ounzain, Damien Maison, Daniel Maric, Rudi Micheletti, Stephen L. Leib, Nathan J. Palpant, Isabelle Plaisance, Michael Alexanian, Stephen P. Jenkinson, Mark Ibberson, Mohamed Nemir, Dominic Villeneuve, Nouria Hernandez, Clayton E. Friedman, Iole Pezzuto, Thierry Pedrazzini, Marco Mina

Publikováno v: Alexanian, Michael; Maric, Daniel; Jenkinson, Stephen Philip; Mina, Marco; Friedman, Clayton E.; Ting, Ching-Chia; Micheletti, Rudi; Plaisance, Isabelle; Nemir, Mohamed; Maison, Damien; Kernen, Jasmin; Pezzuto, Iole; Villeneuve, Dominic; Burdet, Frédéric; Ibberson, Mark; Leib, Stephen; Palpant, Nathan J.; Hernandez, Nouria; Ounzain, Samir and Pedrazzini, Thierry (2017). A transcribed enhancer dictates mesendoderm specification in pluripotency. Nature communications, 8(1), p. 1806. Nature Publishing Group 10.1038/s41467-017-01804-w
Nature Communications, vol. 8, no. 1, pp. 1806
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Nature Communications

Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification. We sort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1395a6aec30b9724e635e5158e41500b
https://boris.unibe.ch/107446/1/s41467-017-01804-w.pdf