Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function.

Autor: Brown ME; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Thirawatananond P; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Peters LD; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Kern EJ; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Vijay S; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Sachs LK; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Posgai AL; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Brusko MA; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Shapiro MR; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Mathews CE; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Bacher R; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Brusko TM; Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA. tbrusko@ufl.edu.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA. tbrusko@ufl.edu.; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA. tbrusko@ufl.edu.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA. tbrusko@ufl.edu.

Publikováno v: Diabetologia [Diabetologia] 2024 Dec 05. Date of Electronic Publication: 2024 Dec 05.