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pro vyhledávání: '"Kern, S. E."'
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Autor:
Tersmette, A. C., Petersen, G. M., Offerhaus, G. J., Falatko, F. C., Brune, K. A., Goggins, M., Rozenblum, E., Wilentz, R. E., Yeo, C. J., Cameron, J. L., Kern, S. E., Hruban, R. H.
Publikováno v:
Clinical cancer research, 7(3), 738-744. American Association for Cancer Research Inc.
It has been estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of patients with pancreatic cancer (PC). The quantified prospective risk of PC among first-degree relatives of PC patients has not been investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::835c29cd3352339d6c2de08d9ad60706
https://pure.amc.nl/en/publications/increased-risk-of-incident-pancreatic-cancer-among-firstdegree-relatives-of-patients-with-familial-pancreatic-cancer(a03a4dec-1dd0-404d-a180-d9863f5aaf80).html
https://pure.amc.nl/en/publications/increased-risk-of-incident-pancreatic-cancer-among-firstdegree-relatives-of-patients-with-familial-pancreatic-cancer(a03a4dec-1dd0-404d-a180-d9863f5aaf80).html
Autor:
Tascilar, M., Skinner, H. G., Rosty, C., Sohn, T., Wilentz, R. E., Offerhaus, G. J., Adsay, V., Abrams, R. A., Cameron, J. L., Kern, S. E., Yeo, C. J., Hruban, R. H., Goggins, M.
Publikováno v:
Clinical cancer research, 7(12), 4115-4121. American Association for Cancer Research Inc.
SMAD4 (also called Dpc4) is a tumor suppressor in the TGF-beta signaling pathway that is genetically inactivated in approximately 55% of all pancreatic adenocarcinomas. We investigated whether prognosis after surgical resection for invasive pancreati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::0d39f4916661e61e29d6f6de04f3156b
https://pure.amc.nl/en/publications/the-smad4-protein-and-prognosis-of-pancreatic-ductal-adenocarcinoma(ebe7d288-c515-4296-94ea-0a2a654e6083).html
https://pure.amc.nl/en/publications/the-smad4-protein-and-prognosis-of-pancreatic-ductal-adenocarcinoma(ebe7d288-c515-4296-94ea-0a2a654e6083).html
Autor:
Wilentz, R. E., Goggins, M., Redston, M., Marcus, V. A., Adsay, N. V., Sohn, T. A., Kadkol, S. S., Yeo, C. J., Choti, M., Zahurak, M., Johnson, K., Tascilar, M., Offerhaus, G. J., Hruban, R. H., Kern, S. E.
Publikováno v:
American journal of pathology, 156(5), 1641-1651. Elsevier Inc.
Medullary carcinomas of the pancreas are a recently described, histologically distinct subset of poorly differentiated adenocarcinomas that may have a unique pathogenesis and clinical course. To further evaluate these neoplasms, we studied genetic, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::1a3f96e809b312c90477eb2dd4319e7c
https://pure.amc.nl/en/publications/genetic-immunohistochemical-and-clinical-features-of-medullary-carcinoma-of-the-pancreas-a-newly-described-and-characterized-entity(81a69342-dfb4-48f2-8bff-5f2fb9588b98).html
https://pure.amc.nl/en/publications/genetic-immunohistochemical-and-clinical-features-of-medullary-carcinoma-of-the-pancreas-a-newly-described-and-characterized-entity(81a69342-dfb4-48f2-8bff-5f2fb9588b98).html
Autor:
Hruban, R. H., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J., Falatko, F., Yeo, C. J., Kern, S. E.
Publikováno v:
Annals of oncology, 10(Suppl. 4), 69-73. Oxford University Press
For many years anecdotal case reports have suggested that pancreatic cancer aggregates in some families. Two recent advances have established that this is in fact the case. First, large registries, such as the National Familial Pancreas Tumor Registr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::bd139da44433076e20c4be2fbb018579
https://pure.amc.nl/en/publications/familial-pancreatic-cancer(5d5d6305-3d36-4d08-9365-aa5a90432e0a).html
https://pure.amc.nl/en/publications/familial-pancreatic-cancer(5d5d6305-3d36-4d08-9365-aa5a90432e0a).html
Publikováno v:
Annals of oncology, 10(Suppl. 4), 4-8. Oxford University Press
In the near future advances in the molecular basis of cancer are expected to facilitate cancer diagnosis, to rationalize treatment, to facilitate screening, and to identify individuals requiring cancer prevention strategies. The literature was review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::2e413a93492315a1f7a2a3e76def1577
https://pure.amc.nl/en/publications/progress-in-cancer-genetics-lessons-from-pancreatic-cancer(5ecb61bd-95aa-48fb-96e3-6fcf9a5d8549).html
https://pure.amc.nl/en/publications/progress-in-cancer-genetics-lessons-from-pancreatic-cancer(5ecb61bd-95aa-48fb-96e3-6fcf9a5d8549).html
Publikováno v:
Annals of oncology, 10(Suppl. 4), 9-11. Oxford University Press
An understanding of incipient pancreatic neoplasia is an essential foundation for the future development of effective screening tests for pancreatic cancer. Only when we understand early pancreatic neoplasms will we be able to detect tumors that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::a04e6fcd5ceb2bd5e6bb3ba07f298b54
https://pure.amc.nl/en/publications/pathology-of-incipient-pancreatic-cancer(e8c155c7-ebd0-41eb-9169-ab7bc648a1ed).html
https://pure.amc.nl/en/publications/pathology-of-incipient-pancreatic-cancer(e8c155c7-ebd0-41eb-9169-ab7bc648a1ed).html
Autor:
Wilentz, R. E., Geradts, J., Maynard, R., Offerhaus, G. J., Kang, M., Goggins, M., Yeo, C. J., Kern, S. E., Hruban, R. H.
Publikováno v:
Cancer research, 58(20), 4740-4744. American Association for Cancer Research Inc.
Pancreatic adenocarcinoma develops from histologically identifiable intraductal lesions that undergo a series of architectural, cytological, and genetic changes. Limited genetic evidence recently suggested that the p16 gene plays a role in the progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::5d8c62c58401c7dfaf1e3ae7e3defe46
https://pure.amc.nl/en/publications/inactivation-of-the-p16-ink4a-tumorsuppressor-gene-in-pancreatic-duct-lesions-loss-of-intranuclear-expression(722f5b53-99d2-44b5-95b8-2bc452470116).html
https://pure.amc.nl/en/publications/inactivation-of-the-p16-ink4a-tumorsuppressor-gene-in-pancreatic-duct-lesions-loss-of-intranuclear-expression(722f5b53-99d2-44b5-95b8-2bc452470116).html
Autor:
Goggins, M., Offerhaus, G. J., Hilgers, W., Griffin, C. A., Shekher, M., Tang, D., Sohn, T. A., Yeo, C. J., Kern, S. E., Hruban, R. H.
Publikováno v:
American journal of pathology, 152(6), 1501-1507. Elsevier Inc.
The clinical and pathological features of carcinomas of the pancreas with DNA replication errors (RER+) have not been characterized. Eighty-two xenografted carcinomas of the pancreas were screened for DNA replication errors using polymerase chain rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::0b7cb2c10752810667a5acd0f2e9a49a
https://pure.amc.nl/en/publications/pancreatic-adenocarcinomas-with-dna-replication-errors-rer-are-associated-with-wildtype-kras-and-characteristic-histopathology-poor-differentiation-a-syncytial-growth-pattern-and-pushing-borders-suggest-rer(38c77cf4-4b84-4554-a2a6-a0ae2f10d701).html
https://pure.amc.nl/en/publications/pancreatic-adenocarcinomas-with-dna-replication-errors-rer-are-associated-with-wildtype-kras-and-characteristic-histopathology-poor-differentiation-a-syncytial-growth-pattern-and-pushing-borders-suggest-rer(38c77cf4-4b84-4554-a2a6-a0ae2f10d701).html
Publikováno v:
ResearcherID
Molecular genetic alterations are known to be important in human carcinoma, but the structural basis of these changes is largely unknown. To examine the basis of these changes, we compared the karyotypic chromosomal abnormalities of primary pancreati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9f4ace0ed6b7524e160e14cd177b1304
https://europepmc.org/articles/PMC1858276/
https://europepmc.org/articles/PMC1858276/