Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Keren Xu"'
1
Akademický článek
Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors
Autor: Keren Xu, Leyi Ying, Titi Ying, Qihao Wu, Lin Du, Yanlei Yu, Youmin Ying, Bin Wei, Hong Wang, Zhikun Yang
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
EcGUS has drawn considerable attention for its role as a target in alleviating serious GIAEs. In this study, a series of 72 (thio)urea derivatives were designed, synthesised, and biologically assayed. The bioassay results revealed that E-9 (IC50 = 2.
Externí odkaz: https://doaj.org/article/deeac22ae7ec4be2ae1419250671037f
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2
Akademický článek
Discovery of Prenyltransferase-Guided Hydroxyphenylacetic Acid Derivatives from Marine Fungus Penicillium sp. W21C371
Autor: Cancan Wang, Ye Fan, Chenjie Wang, Jing Tang, Yixian Qiu, Keren Xu, Yingjia Ding, Ying Liu, Youmin Ying, Hong Wang
Publikováno v: Marine Drugs, Vol 22, Iss 7, p 296 (2024)
Traditional isolation methods often lead to the rediscovery of known natural products. In contrast, genome mining strategies are considered effective for the continual discovery of new natural products. In this study, we discovered a unique prenyltra
Externí odkaz: https://doaj.org/article/e53843bf4b644556880a41269f3aa441
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3
Akademický článek
Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population
Autor: Qianxi Feng, Keren Xu, Mancy Shah, Shaobo Li, Andrew D. Leavitt, Lucy A. Godley, Adam J. de Smith, Joseph L. Wiemels
Publikováno v: Haematologica, Vol 999, Iss 1 (2024)
Genetic predisposition to hematologic malignancies has historically been addressed utilizing patients recruited from clinical trials and pedigrees constructed at major treatment centers. Such efforts leave unexplored the genetic basis of variations i
Externí odkaz: https://doaj.org/article/c44aecf7950842afa62ad47d9333a46d
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4
Akademický článek
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis
Autor: Yuexin Wu, Yuyan Cao, Keren Xu, Yue Zhu, Yuemei Qiao, Yanjun Wu, Jianfeng Chen, Chen Li, Rong Zeng, Gaoxiang Ge
Publikováno v: Cell Death and Disease, Vol 12, Iss 2, Pp 1-15 (2021)
Abstract Liver cirrhosis remains major health problem. Despite the progress in diagnosis of asymptomatic early-stage cirrhosis, prognostic biomarkers are needed to identify cirrhotic patients at high risk developing advanced stage disease. Liver cirr
Externí odkaz: https://doaj.org/article/9f27624142694f298e7c649b02ab92ca
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5
Akademický článek
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway
Autor: Jin-Zhu Wang, Hong Zhu, Pu You, Hui Liu, Wei-Kang Wang, Xiaojuan Fan, Yun Yang, Keren Xu, Yingfeng Zhu, Qunyi Li, Ping Wu, Chao Peng, Catherine C.L. Wong, Kaicheng Li, Yufeng Shi, Nu Zhang, Xiuxing Wang, Rong Zeng, Ying Huang, Liusong Yang, Zefeng Wang, Jingyi Hui
Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Y-box–binding protein 1 (YB-1) is a multifunctional RNA binding protein involved in virtually every step of RNA metabolism. However, the functions and mechanisms of YB-1 in one of the most aggressive cancers, glioblastoma, are not well understood.
Externí odkaz: https://doaj.org/article/ba4ef9a35730430dad7215c017706423
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8
Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men
Autor: Anqi Wang, Yili Xu, Yao Yu, Kevin T Nead, TaeBeom Kim, Keren Xu, Tokhir Dadaev, Ed Saunders, Xin Sheng, Peggy Wan, Loreall Pooler, Lucy Y Xia, Stephen Chanock, Sonja I Berndt, Susan M Gapstur, Victoria Stevens, Demetrius Albanes, Stephanie J Weinstein, Vincent Gnanapragasam, Graham G Giles, Tu Nguyen-Dumont, Roger L Milne, Mark M Pomerantz, Julie A Schmidt, Konrad H Stopsack, Lorelei A Mucci, William J Catalona, Kurt N Hetrick, Kimberly F Doheny, Robert J MacInnis, Melissa C Southey, Rosalind A Eeles, Fredrik Wiklund, Zsofia Kote-Jarai, Adam J de Smith, David V Conti, Chad Huff, Christopher A Haiman, Burcu F Darst
Publikováno v: Wang, A, Xu, Y, Yu, Y, Nead, K T, Kim, T B, Xu, K, Dadaev, T, Saunders, E, Sheng, X, Wan, P, Pooler, L, Xia, L Y, Chanock, S, Berndt, S I, Gapstur, S M, Stevens, V, Albanes, D, Weinstein, S J, Gnanapragasam, V, Giles, G G, Nguyen-Dumont, T, Milne, R L, Pomerantz, M M, Schmidt, J A, Stopsack, K H, Mucci, L A, Catalona, W J, Hetrick, K N, Doheny, K F, MacInnis, R J, Southey, M C, Eeles, R A, Wiklund, F, Kote-Jarai, Z, de Smith, A J, Conti, D V, Huff, C, Haiman, C A & Darst, B F 2023, ' Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men ', Human Molecular Genetics, vol. 32, no. 3, pp. 489-495 . https://doi.org/10.1093/hmg/ddac214
Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is the expansion of hematopoietic stem cells with somatic mutations, and risk of prostate cancer, the fifth leading cause
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4741fc3a448342e6e513e658f66c2b0f
https://pure.au.dk/portal/da/publications/clonal-hematopoiesis-and-risk-of-prostate-cancer-in-large-samples-of-european-ancestry-men(e0777d6d-3f9f-45e2-875b-233cbc32b981).html
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9
Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia
Autor: Keren Xu, Shaobo Li, Priyatama Pandey, Alice Y Kang, Libby M Morimoto, Nicholas Mancuso, Xiaomei Ma, Catherine Metayer, Joseph L Wiemels, Adam J de Smith
Publikováno v: Human molecular genetics, vol 31, iss 21
Hum Mol Genet
Genome-wide association studies have identified a growing number of single nucleotide polymorphisms (SNPs) associated with childhood acute lymphoblastic leukemia (ALL), yet the functional roles of most SNPs are unclear. Multiple lines of evidence sug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e5eb4b07acee3a208882400f4785e3
https://escholarship.org/uc/item/0795j42r
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10
Accelerated epigenetic aging in newborns with Down syndrome
Autor: Keren Xu, Shaobo Li, Ivo S. Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M. Hansen, Libby M. Morimoto, Alice Y. Kang, Xiaomei Ma, Catherine Metayer, Beth A. Mueller, Irene Roberts, Kyle M. Walsh, Steve Horvath, Joseph L. Wiemels, Adam J. de Smith
Publikováno v: Aging cell, vol 21, iss 7
Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early-onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f071565a107059953773a95d8a7c74
https://ora.ox.ac.uk/objects/uuid:c2e2f9d2-5afa-4bfb-9498-460e8b1c54f7
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