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Shaping Functional Avidity of CAR T Cells: Affinity, Avidity, and Antigen Density That Regulate Response

Autor: Vered Bronner, Keren Sinik, Alona Goor, Maya Haus-Cohen, Yael Elbaz, Yoav Pizem, Raanan Greenman, Shai S. Shen-Orr, Galit Denkberg, Anat Levin, Guy Horev, Yoram Reiter, Galit Horn

Publikováno v: Molecular cancer therapeutics. 20(5)

Chimeric antigen receptors (CARs) are immunoreceptors that redirect T cells to selectively kill tumor cells. Given their clinical successes in hematologic malignancies, there is a strong aspiration to advance this immunotherapy for solid cancers; hen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f541dc397b4a0d342f7948fce8683f
https://pubmed.ncbi.nlm.nih.gov/33649106

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Melanoma cells present high levels of HLA-A2-tyrosinase in association with instability and aberrant intracellular processing of tyrosinase

Autor: Yael, Michaeli, Keren, Sinik, Maya, Haus-Cohen, Yoram, Reiter

Publikováno v: European journal of immunology. 42(4)

Short-lived protein translation products are proposed to be a major source of substrates for major histocompatibility complex (MHC) class I antigen processing and presentation; however, a direct link between protein stability and the presentation lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b21f083d524589c398aa7bac3c93ab96
https://pubmed.ncbi.nlm.nih.gov/22531911

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Expression hierarchy of T cell epitopes from melanoma differentiation antigens: unexpected high level presentation of tyrosinase-HLA-A2 Complexes revealed by peptide-specific, MHC-restricted, TCR-like antibodies

Autor: Celine Beauverd, Yael Michaeli, Pedro Romero, Liz Lantzy, Keren Sinik, Chiang Chih-Sheng, Tamar Ziv, Yoram Reiter, Galit Denkberg

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 182(10)

Peptide Ags presented by class I MHC molecules on human melanomas and that are recognized by CD8+ T cells are the subjects of many studies of antitumor immunity and represent attractive candidates for therapeutic approaches. However, no direct quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63d99289ee3ca9edb92523fca162cfd
https://pubmed.ncbi.nlm.nih.gov/19414786

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