Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Keren Shtiegman"'
Autor:
Yossi Machluf, Yaron Mosesson, Liat Yakir, Menachem Katz, Hironobu Asao, Keren Shtiegman, Daniel Harari, Thomas M. Jovin, Pazit Tal-Or, Kazuo Sugamura, Yosef Yarden
Publikováno v:
Traffic. 3:740-751
Ligand-dependent endocytosis of the epidermal growth factor receptor (EGFR) involves recruitment of a ubiquitin ligase, and sorting of ubiquitylated receptors to lysosomal degradation. By studying Hgs, a mammalian homolog of a yeast vacuolar-sorting
Autor:
Ari Elson, Menachem Katz, Thomas M. Jovin, Sara Lavi, Chanan Rubin, Keren Shtiegman, Hadassa Waterman, Yosef Yarden
Publikováno v:
EMBO Journal
Ligand-induced desensitization of the epidermal growth factor receptor (EGFR) is controlled by c-Cbl, a ubiquitin ligase that binds multiple signaling proteins, including the Grb2 adaptor. Consistent with a negative role for c-Cbl, here we report tha
Autor:
Silvia Giordano, Menachem Katz, Akiva Vexler, Sara Lavi, S Benjamin, Yaara Zwang, Bose Kochupurakkal, Gur Pines, Keren Shtiegman, Y Ben-Basat, Yosef Yarden, Simona Corso, Ami Citri, Judith Gan, Rami Ben Yosef, Alex Starr
Publikováno v:
Oncogene. 26(49)
Several distinct mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are associated with non-small cell lung cancer, but mechanisms underlying their oncogenic potential are incompletely understood. Although normally liga
Autor:
Elena Santonico, Keren Shtiegman, Bose Kochupurakkal, Menachem Katz, Sara Lavi, Mina D. Marmor, Yaron Mosesson, Yaara Zwang, Shlomo Oved, Yosef Yarden, Gianni Cesareni
Publikováno v:
The Journal of biological chemistry. 281(31)
When appended to the epidermal growth factor receptor (EGFR), ubiquitin serves as a sorting signal for lysosomal degradation. Here we demonstrate that the ubiquitin ligase of EGFR, namely c-Cbl, also mediates receptor modification with the ubiquitin-
Autor:
Yuval Reiss, Liat Yakir, Eli Roubini, Keren Shtiegman, Ullrich Schubert, Shmuel Tuvia, Menachem Katz, Yaara Zwang, Mina D. Marmor, Maya Cohen, Ron Wides, Eran Bacharach, Iris Alroy, Ido Amit, Yosef Yarden, Ami Citri
Publikováno v:
Genesdevelopment. 18(14)
The tumor suppressor gene 101 (tsg101) regulates vesicular trafficking processes in yeast and mammals. We report a novel protein, Tal (Tsg101-associated ligase), whose RING finger is necessary for multiple monoubiquitylation of Tsg101. Bivalent bindi
Autor:
Gyorgi Vereb, János Szöllosi, Yaara Zwang, Keren Shtiegman, Menachem Katz, Yosef Yarden, Yaron Mosesson
Growth factors stimulate specific receptor tyrosine kinases, but subsequent receptor endocytosis terminates signaling. The ubiquitin ligase c-Cbl targets epidermal growth factor receptors (EGFRs) to endocytosis by tagging them with multiple ubiquitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6319d19de70d600a2d6573baa8c7ea76
Autor:
Keren Shtiegman, Yosef Yarden
Publikováno v:
Seminars in cancer biology. 13(1)
Cancer cells depend on multiple, locally produced growth factors. Signaling by growth factors entails phosphorylation events, and its termination is determined primarily by endocytosis of growth factor receptor complexes. One group of growth factor r
Autor:
Menachem, Katz, Keren, Shtiegman, Pazit, Tal-Or, Liat, Yakir, Yaron, Mosesson, Daniel, Harari, Yossi, Machluf, Hironobu, Asao, Thomas, Jovin, Kazuo, Sugamura, Yosef, Yarden
Publikováno v:
Traffic (Copenhagen, Denmark). 3(10)
Ligand-dependent endocytosis of the epidermal growth factor receptor (EGFR) involves recruitment of a ubiquitin ligase, and sorting of ubiquitylated receptors to lysosomal degradation. By studying Hgs, a mammalian homolog of a yeast vacuolar-sorting
Publikováno v:
Physiologybehavior. 63(5)
The immediate and long-term biologic and behavioral consequences of voluntary ethanol (EtOH) exposure during male adolescence are unknown. In the present study, male golden hamsters voluntarily drank from a 15% EtOH solution in addition to consuming