Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Keren L Witkin"'
Autor:
Joan A. Steitz, Peter C. Dedon, Elizabeth Read-Connole, Jennifer A Strasburger, Samie R. Jaffrey, T Kevin Howcroft, John M. Coffin, Sean E. Hanlon, Phil J Daschner, Keren L Witkin
Publikováno v:
Cancer Biology & Therapy. 16:21-27
The transcriptome is extensively and dynamically regulated by a network of RNA modifying factors. RNA editing enzymes APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) and ADAR (adenosine deaminase, RNA-specific) irreversibly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaad7dbe8a25926365d2941e7d8b8a4
https://doi.org/10.4161/15384047.2014.987555
https://doi.org/10.4161/15384047.2014.987555
Publikováno v:
Journal of Cell Science. 122:1477-1486
The nucleus is one of the most prominent cellular organelles, yet surprisingly little is known about how it is formed, what determines its shape and what defines its size. As the nuclear envelope (NE) disassembles in each and every cell cycle in meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f88e66ff97f2053201f8f68d238da6
https://doi.org/10.1242/jcs.037333
https://doi.org/10.1242/jcs.037333
Publikováno v:
Molecular and Cellular Biology. 27:2074-2083
Telomerase replenishes the telomeric repeats that cap eukaryotic chromosome ends. To perform DNA synthesis, the active site of telomerase reverse transcriptase (TERT) copies a template within the integral telomerase RNA (TER). In vivo, TERT and TER a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13063fac39b560c1ee2f31a304e85a96
https://doi.org/10.1128/mcb.02105-06
https://doi.org/10.1128/mcb.02105-06
Autor:
Keren L. Witkin, Kathleen Collins
Publikováno v:
Genes & Development. 18:1107-1118
Many proteins have been implicated in the physiological function of telomerase, but specific roles of telomerase-associated proteins other than telomerase reverse transcriptase (TERT) remain ambiguous. To gain a more comprehensive understanding of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79f99898b395b8eb419ed1a7f9e6cea
https://doi.org/10.1101/gad.1201704
https://doi.org/10.1101/gad.1201704
Autor:
Judice L. Y. Koh, Sichen Shao, Orna Cohen-Fix, Alison D. Walters, Sujoy Lahiri, Brandon Lee, Yolanda T. Chong, Keren L. Witkin, William A. Prinz, Micah T. Webster, Brenda J. Andrews
Publikováno v:
Current biology : CB. 22(12)
SummaryThe mechanisms that dictate nuclear shape are largely unknown. Here we screened the budding yeast deletion collection for mutants with abnormal nuclear shape. A common phenotype was the appearance of a nuclear extension, particularly in mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428bf5fbb8508093ca2bafd69f2d7506
https://pubmed.ncbi.nlm.nih.gov/22720683
https://pubmed.ncbi.nlm.nih.gov/22720683
Publikováno v:
Genetics. 186(3)
The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a2549c24c4aba01662ae6136095710
https://pubmed.ncbi.nlm.nih.gov/20713690
https://pubmed.ncbi.nlm.nih.gov/20713690
Autor:
Joseph L. Campbell, Josef Loidl, Orna Cohen-Fix, Thomas Hays, Keren L. Witkin, Alexander Lorenz
Little is known about what dictates the round shape of the yeast Saccharomyces cerevisiae nucleus. In spo7Delta mutants, the nucleus is misshapen, exhibiting a single protrusion. The Spo7 protein is part of a phosphatase complex that represses phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215ab429d30810ca97abfbb0ec8a6c69
https://hdl.handle.net/11353/10.244491
https://hdl.handle.net/11353/10.244491
Telomerase maintains the simple sequence repeats at chromosome ends, protecting cells from genomic rearrangement, proliferative senescence and death. The telomerase reverse transcriptase (TERT) and telomerase RNA (TER) alone can assemble into active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6bf27fc876803011f12cd3b3cfcd1
https://europepmc.org/articles/PMC2913471/
https://europepmc.org/articles/PMC2913471/