Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Keren Isaev"'
Autor:
Victoria Shelton, Rajesh Detroja, Ting Liu, Keren Isaev, Anjali Silva, Verena Passerini, Mehran Bakhtiari, Lourdes Calvente, Michael Hong, Michael Y. He, Saloni Modi, Samantha A. Hershenfeld, Maja Ludvigsen, Charlotte Madsen, Stephen Hamilton-Dutoit, Francesco Annibale d’Amore, Marianne Brodtkorb, Nathalie A. Johnson, Tara Baetz, David LeBrun, Josh W. D. Tobin, Maher K. Gandhi, Andrew J. Mungall, Wei Xu, Susana Ben-Neriah, Christian Steidl, Jan Delabie, Rosemarie Tremblay-LeMay, Opeyemi Jegede, Oliver Weigert, Brad Kahl, Andrew M. Evens, Robert Kridel
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Follicular lymphoma (FL) exhibits considerable variability in biological features and clinical trajectories across patients. To dissect the diversity of FL, we utilized a Bernoulli mixture model to identify genetic subtypes in 713 pre-treatm
Externí odkaz:
https://doaj.org/article/34d7cb757e0c4fbe916aa9cea2b4742d
Autor:
Keren Isaev, Ting Liu, Mehran Bakhtiari, Kit Tong, Rashmi Goswami, Bernard Lam, Ilinca Lungu, Paul M. Krzyzanowski, Amit Oza, Neesha Dhani, Anca Prica, Michael Crump, Robert Kridel
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
Intratumoral heterogeneity (ITH) provides the substrate for tumor evolution and treatment resistance, yet is remarkably understudied in lymphoma, due to the often limited amount of tissue that gets sampled during the routine diagnostic process, gener
Externí odkaz:
https://doaj.org/article/3ee4832efddb40a5b5d0db82a4a717e9
Autor:
Keren Isaev, Lingyan Jiang, Shuai Wu, Christian A. Lee, Valérie Watters, Victoire Fort, Ricky Tsai, Fiona J. Coutinho, Samer M.I. Hussein, Jie Zhang, Jinsong Wu, Peter B. Dirks, Daniel Schramek, Jüri Reimand
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109873- (2021)
Summary: Long non-coding RNAs (lncRNAs) are increasingly recognized as functional units in cancer and powerful biomarkers; however, most remain uncharacterized. Here, we analyze 5,592 prognostic lncRNAs in 9,446 cancers of 30 types using machine lear
Externí odkaz:
https://doaj.org/article/b8deb1b808b7470e9f2e013c39c9bbb4
Autor:
Keren Isaev, Daisuke Ennishi, Laura Hilton, Brian Skinnider, Karen L. Mungall, Andrew J. Mungall, Mehran Bakhtiari, Rosemarie Tremblay-LeMay, Anjali Silva, Susana Ben-Neriah, Merrill Boyle, Diego Villa, Marco A. Marra, Christian Steidl, Randy D. Gascoyne, Ryan Morin, Kerry J. Savage, David W. Scott, Robert Kridel
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
Externí odkaz:
https://doaj.org/article/9cad7cbc767c4ef182f5592f7af57bb7
Autor:
Victoria Shelton, Keren Isaev, Ting Liu, Anjali Silva, Rajesh Detroja, Mehran Bakhtiari, Lourdes Calvente, Michael Hong, Saloni Modi, Samantha A Hershenfeld, Maja Ludvigsen, Francesco Annibale d'Amore, Marianne Brodtkorb, Nathalie A. Johnson, Tara Baetz, David LeBrun, Josh Tobin, Maher K. Gandhi, Andrew J. Mungall, Christian Steidl, Jan Delabie, Rosemarie Tremblay-Lemay, Brad S. Kahl, Andrew M Evens, Robert Kridel
Publikováno v:
Blood. 140:6371-6373
Autor:
Sunit Das, Jüri Reimand, Michael D. Taylor, Michael F. Moran, Peter B. Dirks, David G. Munoz, Sayf Al-Omaishi, Taylor M. Wilson, Jeffrey Chan, Jiefei Tong, Jennifer Guan, A. Sorana Morrissy, Keren Isaev, Angela Celebre, Kimia Ghannad-Zadeh, Oleksandra Kaskun, Sandra Smiljanic, Megan Wu, Rohit Sachdeva
Measurement of ID1 half-life by cycloheximide chase assays. U251 cells were pretreated with or without TMZ for 3 days, followed by treatment with cycloheximide for the indicated times. The cell lysates were then analyzed by Western blots.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10c32850fd8b6a6fb374e4fba0640b6
https://doi.org/10.1158/0008-5472.22422143
https://doi.org/10.1158/0008-5472.22422143
Autor:
Robert Kridel, Christian Steidl, David W. Scott, Merrill Boyle, Lauren C. Chong, Elizabeth A. Chavez, Rodger E. Tiedemann, Housheng Hansen He, Gilbert G. Privé, Maria C. Xu, Anjali Silva, Jesse Joynt, Michael Y. He, Tracy Lackraj, Mehran Bakhtiari, Keren Isaev, Sharon Yoon, Kit I. Tong
Results from CRISPR/Cas9 knockout screen in SU-DHL-4 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4c08af6454c34ea2a2834ec2eb5ad3
https://doi.org/10.1158/1078-0432.22481609.v1
https://doi.org/10.1158/1078-0432.22481609.v1
Autor:
Robert Kridel, Christian Steidl, David W. Scott, Merrill Boyle, Lauren C. Chong, Elizabeth A. Chavez, Rodger E. Tiedemann, Housheng Hansen He, Gilbert G. Privé, Maria C. Xu, Anjali Silva, Jesse Joynt, Michael Y. He, Tracy Lackraj, Mehran Bakhtiari, Keren Isaev, Sharon Yoon, Kit I. Tong
Purpose:The efficacy of EZH2 inhibition has been modest in the initial clinical exploration of diffuse large B-cell lymphoma (DLBCL), yet EZH2 inhibitors are well tolerated. Herein, we aimed to uncover genetic and pharmacologic opportunities to enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea15c004b3550df88ad0d2b64db44c
https://doi.org/10.1158/1078-0432.c.6530741.v1
https://doi.org/10.1158/1078-0432.c.6530741.v1
Autor:
Robert Kridel, Christian Steidl, David W. Scott, Merrill Boyle, Lauren C. Chong, Elizabeth A. Chavez, Rodger E. Tiedemann, Housheng Hansen He, Gilbert G. Privé, Maria C. Xu, Anjali Silva, Jesse Joynt, Michael Y. He, Tracy Lackraj, Mehran Bakhtiari, Keren Isaev, Sharon Yoon, Kit I. Tong
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedf107ae003a03ebdc635ba308d6ab9
https://doi.org/10.1158/1078-0432.22481612.v1
https://doi.org/10.1158/1078-0432.22481612.v1
Autor:
Sunit Das, Jüri Reimand, Michael D. Taylor, Michael F. Moran, Peter B. Dirks, David G. Munoz, Sayf Al-Omaishi, Taylor M. Wilson, Jeffrey Chan, Jiefei Tong, Jennifer Guan, A. Sorana Morrissy, Keren Isaev, Angela Celebre, Kimia Ghannad-Zadeh, Oleksandra Kaskun, Sandra Smiljanic, Megan Wu, Rohit Sachdeva
Glioblastoma is the most common primary brain tumor in adults. While the introduction of temozolomide chemotherapy has increased long-term survivorship, treatment failure and rapid tumor recurrence remains universal. The transcriptional regulatory pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb4fa204e934da56212b1a03b0ad92b2
https://doi.org/10.1158/0008-5472.c.6511136.v1
https://doi.org/10.1158/0008-5472.c.6511136.v1