BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis

Autor: Jacob D. Garritson, Jiabi Zhang, Alan Achenbach, Maroua Ferhat, Emile Eich, Chris J. Stubben, Paige L. Martinez, Anna R. Ibele, Keren I. Hilgendorf, Sihem Boudina

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract Autocrine and paracrine signaling regulating adipogenesis in white adipose tissue remains largely unclear. Here we used single-cell RNA-sequencing (RNA-seq) and single nuclei RNA-sequencing (snRNA-seq) to identify markers of adipose progenit

Externí odkaz: https://doaj.org/article/ea29e9686fc0499989d23cbee9f8bf05

Ciliary control of adipocyte progenitor cell fate regulates energy storage

Autor: Sierra R. Scamfer, Mark D. Lee, Keren I. Hilgendorf

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cells in our adipose tissue, a complex organ involved in energy storage, endocrine signaling, and thermogenesis. Numerous studies h

Externí odkaz: https://doaj.org/article/706a4f9c43794bd18d748acfd0805f3c

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Autor: Ermelinda Porpiglia, Thach Mai, Peggy Kraft, Colin A. Holbrook, Antoine de Morree, Veronica D. Gonzalez, Keren I. Hilgendorf, Laure Frésard, Angelica Trejo, Sriram Bhimaraju, Peter K. Jackson, Wendy J. Fantl, Helen M. Blau

Publikováno v: Porpiglia, E, Mai, T, Kraft, P, Holbrook, C A, de Morree, A, Gonzalez, V D, Hilgendorf, K I, Frésard, L, Trejo, A, Bhimaraju, S, Jackson, P K, Fantl, W J & Blau, H M 2022, ' Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration ', Cell Stem Cell, vol. 29, no. 12, pp. 1653-1668.e8 . https://doi.org/10.1016/j.stem.2022.10.009
Porpiglia, E 2022, ' Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration ', Cell Stem Cell, vol. 29, pp. 1-15 . https://doi.org/10.1016/j.stem.2022.10.009

SUMMARYIn aging, skeletal muscle strength and regenerative capacity declines due, in part, to functional impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain elusive. Here we capitalize on mass-cytometry to identify high CD47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04ad7c0435d5c85adc8688e5f4b2667
https://pure.au.dk/portal/da/publications/elevated-cd47-is-a-hallmark-of-dysfunctional-aged-muscle-stem-cells-that-can-be-targeted-to-augment-regeneration(c5ff0522-3d96-48d3-98c9-5ebe9d67b333).html

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

Autor: Romina J. Bevacqua, Chien-Ting Wu, Keren I. Hilgendorf, Seung K. Kim, Peter K. Jackson, Yan Hang, Janos Demeter

SummaryMultiple G protein coupled receptors (GPCRs) are expressed in pancreatic islet cells but the majority have unknown functions. We observe specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α- and β-cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50f372fb0f539026ff13b49b0cce865b
https://doi.org/10.1101/2020.10.21.349423

Ciliation of muscle stem cells is critical to maintain regenerative capacity and is lost during aging

Autor: Keren I. Hilgendorf, Helen M. Blau, Adelaida R. Palla, Aaron C. Hinken, Nora Yucel, Jaclyn P. Kerr, Peter K. Jackson, Ann V Yang, Nancie Mooney, Janos Demeter, Peggy E. Kraft

During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We performed a small molecule library screen and discovered that the proliferation and expansion of aged MuS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64abffcaf26c6e74fee59a18f6b51090