Výsledky vyhledávání - "Kerem Erekul"

Adaptation of Human CD4+ T Cells to Pathophysiological Hypoxia: A Transcriptome Analysis

Autor: Frank Buttgereit, Gerd-Rüdiger Burmester, Grit Sandig, René Dziurla, Monique Fangradt, Karolina Tykwinska, Kerem Erekul, Paula Kolar, Martin Lautenbach, Miriam Tschirschmann, Timo Gaber, Thomas Häupl, M. Hahne

Publikováno v: The Journal of Rheumatology. 36:2655-2669

Objective.Inflamed tissues are usually characterized by low oxygen levels. We investigated whether pathophysiological hypoxia (pO2< 1%) as found in the rheumatoid synovium modulates the transcriptome of human CD4+ T cells.Methods.We analyzed the exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808b16d048f071930a1f42e3e2a180eb
https://doi.org/10.3899/jrheum.090255

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Human CD4+ T cells maintain specific functions even under conditions of extremely restricted ATP production

Autor: René Dziurla, Robert Tripmacher, Gerd-Rüdiger Burmester, Timo Gaber, Thomas Häupl, Andreas Radbruch, Andreas Grützkau, Kerem Erekul, Frank Buttgereit, Alexander Scheffold, Miriam Tschirschmann

Publikováno v: European Journal of Immunology. 38:1631-1642

We investigated the energy-adaptive potential of human CD4(+) T cells under conditions of impaired oxidative phosphorylation (OXPHOS) and/or low glucose (inhibiting glycolysis). These cells often encounter these conditions when executing their functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaba18cb5167b6372e58f4e1820e0450
https://doi.org/10.1002/eji.200738047

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Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia

Autor: Gerd-Rüdiger Burmester, Cindy Stahn, Frank Buttgereit, Paula Kolar, Kerem Erekul, René Dziurla, Patrick Maschmeyer, Max Löhning, Markus Wagegg, Karolina Tykwinska, Saskia Schellmann, Monique Fangradt, Timo Gaber, M. Hahne

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 186(2)

Hypoxia, a feature of inflammation and tumors, is a potent inducer of the proinflammatory cytokine macrophage migration inhibitory factor (MIF). In transformed cells, MIF was shown to modulate and to be modulated via the oxygen-sensitive transcriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ca421eb53ab735792f7adfe1f52b6e
https://pubmed.ncbi.nlm.nih.gov/21169549

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