Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Keqing Zhang"'
Autor:
Emily D. Morales, Dongxin Wang, Matthew J. Burke, Jin Han, Drake D. Devine, Keqing Zhang, Dongsheng Duan
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Cytosolic calcium overload contributes to muscle degradation in Duchenne muscular dystrophy (DMD). The sarcoplasmic reticulum (SR) is the primary calcium storage organelle in muscle. The sarco-endoplasmic reticulum ATPase (SERCA)
Externí odkaz:
https://doaj.org/article/42fb4df068464dd18c06c51b7a99e1db
Autor:
Yuexia Lin, Lingwei Sun, Yuhua Lv, Rongrong Liao, Keqing Zhang, Jinyong Zhou, Shushan Zhang, Jiehuan Xu, Mengqian He, Caifeng Wu, Defu Zhang, Xiaohui Shen, Jianjun Dai, Jun Gao
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background The transcriptome and metabolome dissection of the skeletal muscle of high- and low- growing individuals from a crossbred population of the indigenous Chongming white goat and the Boer goat were performed to discover the potential
Externí odkaz:
https://doaj.org/article/6e5d3323b62d41e1b206cd0c8a0d6b0c
Autor:
Chaoyue Chen, Keqing Zhang, Ruixin Zhao, Songzhe Xu, Tao Hu, Xia Li, Xiaopeng Li, Linda Ke, Jiang Wang, Zhongming Ren
Publikováno v:
Virtual and Physical Prototyping, Vol 19, Iss 1 (2024)
In the present work, the static magnetic field (SMF) was applied in the L-PBF process of a typical γʹ strengthening Ni-based superalloy of GH4099 concerning the as-built and heat-treated conditions. The SMF during the L-PBF process can effectively
Externí odkaz:
https://doaj.org/article/39d0059b8e9241568527b88e41dd0bf0
Autor:
Kasun Kodippili, Chady H. Hakim, Matthew J. Burke, Yongping Yue, James A. Teixeira, Keqing Zhang, Gang Yao, Gopal J. Babu, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101268- (2024)
Excessive cytosolic calcium accumulation contributes to muscle degeneration in Duchenne muscular dystrophy (DMD). Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a sarcoplasmic reticulum (SR) calcium pump that actively transports calcium from t
Externí odkaz:
https://doaj.org/article/8999a19b16ac45ccb94ac3fd43620ab2
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTThis study investigated resistance genes corresponding to the fosfomycin resistance phenotype in clinical isolate Providencia rettgeri W986, as well as characterizing the enzymatic activity of FosA11 and the genetic environment. Antimicrobial
Externí odkaz:
https://doaj.org/article/ba30946fdb3e4d329e1cb1d478b71498
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-4 (2023)
Abstract Background Henoch-Schönlein purpura (HSP) is a common form of immunological vasculitis in children. Hemophilia A is a genetic disorder and characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII deficiency. Both dis
Externí odkaz:
https://doaj.org/article/e850032413014f02b4a6c84ad07395af
Autor:
Jun Gao, Lingwei Sun, Hongmei Pan, Shushan Zhang, Jiehuan Xu, Mengqian He, Keqing Zhang, Jinyong Zhou, Defu Zhang, Caifeng Wu, Jianjun Dai
Publikováno v:
Animals, Vol 13, Iss 23, p 3727 (2023)
China has rich genetic resources of local pig breeds. In this study, whole-genome resequencing was performed on five Shanghai local pig breeds, aiming to analyze their population genetic structure and unique genomic characteristics. Tens of millions
Externí odkaz:
https://doaj.org/article/2f68042653bb44b4a834af6d7dd791cd
Autor:
Chady H. Hakim, Sandeep R. P. Kumar, Dennis O. Pérez-López, Nalinda B. Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D. Million, Christopher E. Nelson, Samantha Metzger, Jin Han, Jacqueline A. Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F. Smith, Gang Yao, N. Nora Yang, Charles A. Gersbach, Shi-jie Chen, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Cas9-specific T cell response has been speculated to impair CRISPR therapy. Here, the authors show that local and systemic AAV CRISPR therapy induces cytotoxic killing and eliminates rescued dystrophin in canine models of Duchenne muscular dystro
Externí odkaz:
https://doaj.org/article/fa789cec57864e868cf64db8cae359c5
Autor:
Chady H. Hakim, Nathalie Clément, Lakmini P. Wasala, Hsiao T. Yang, Yongping Yue, Keqing Zhang, Kasun Kodippili, Laura Adamson-Small, Xiufang Pan, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Barry J. Byrne, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 664-678 (2020)
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Externí odkaz:
https://doaj.org/article/c9a8a753dbc949b9af502c5c8edc3335
Autor:
Junling Zhao, Yongping Yue, Aman Patel, Lakmini Wasala, Jacob F. Karp, Keqing Zhang, Dongsheng Duan, Yi Lai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 856-868 (2020)
Adeno-associated virus (AAV) is one of the most important gene delivery vehicles for in vivo gene therapy. Intramuscular (i.m.) and intravascular (i.v.) injection are commonly used for AAV gene transfer. Unfortunately, the fate of AAV vectors followi
Externí odkaz:
https://doaj.org/article/4fb0a205845f4a4dad366edfc0540947