Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Keqiang Ye"'
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-17 (2024)
Abstract The deposition of abnormal tau protein is characteristic of Alzheimer’s disease (AD) and a class of neurodegenerative diseases called tauopathies. Physiologically, tau maintains an intrinsically disordered structure and plays diverse roles
Externí odkaz:
https://doaj.org/article/8400d7606f904ab8ae74d9e396a62571
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102788- (2024)
Summary: Alpha-synuclein (α-Syn) positron emission tomography (PET) imaging is a valuable approach for diagnosing and monitoring synucleinopathies-related diseases, such as Parkinson disease. Here, we present a protocol for screening potential α-Sy
Externí odkaz:
https://doaj.org/article/a64b2d43058d4a3b85f082842c9ab308
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 4, Pp 960-972 (2025)
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development. Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function. Inc
Externí odkaz:
https://doaj.org/article/9f7cbcc17f1c4a4d8968026282aab363
Autor:
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the br
Externí odkaz:
https://doaj.org/article/6b764bb85ea2452a913aa80974bdc655
Autor:
Jing Xiong, Seong Su Kang, Mengmeng Wang, Zhihao Wang, Yiyuan Xia, Jianming Liao, Xia Liu, Shan-Ping Yu, Zhaohui Zhang, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Alzheimer’s disease (AD) is the most common dementia. It is known that women with one ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we previously showed that follicle–stimulating hormone (FSH), a g
Externí odkaz:
https://doaj.org/article/cf07fd8c87ba4e7683eb0263ddb3fa3b
Autor:
Yiyuan Xia, Yifan Xiao, Zhi-Hao Wang, Xia Liu, Ashfaqul M. Alam, John P. Haran, Beth A. McCormick, Xiji Shu, Xiaochuan Wang, Keqiang Ye
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Gut dysbiosis contributes to Alzheimer’s disease (AD) pathogenesis, and Bacteroides strains are selectively elevated in AD gut microbiota. However, it remains unknown which Bacteroides species and how their metabolites trigger AD pathologi
Externí odkaz:
https://doaj.org/article/1a38d79f173040fea4f29109c187ef74
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase
Autor:
Ting Yu, Shuke Nie, Lihong Bu, Miao Liu, Juanfeng He, Xuan Niu, Hongyan Feng, Jifeng Guo, Beisha Tang, Zhaohui Zhang, Keqiang Ye, Haiqiang Jiang, Liam Chen, Zhentao Zhang
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Cerebrotendinous xanthomatosis (CTX), an autosomal recessive disorder characterized by high levels of cholestanol in the blood and accumulation of cholestanol in multiple tissues, especially the brain, often presents in parkinsonism. However, it rema
Externí odkaz:
https://doaj.org/article/955afeea90bf46348fadccd5ba1ffd28
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/232d1ba115c44f2696dedb0663a1fce4
Autor:
Hualong Wang, Guiqin Chen, Eun Hee Ahn, Yiyuan Xia, Seong Su Kang, Xia Liu, Chang Liu, Ming-Hu Han, Shengdi Chen, Keqiang Ye
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Parkinson’s disease (PD) is the most common neurodegenerative motor disorder, and its pathologic hallmarks include extensive dopaminergic neuronal degeneration in the Substantia nigra associated with Lewy bodies, predominantly consisting o
Externí odkaz:
https://doaj.org/article/e6b4b28683c344a0b073d73e4544a94e
Autor:
Si-Bo Zhou, Man Xue, Weiqi Liu, Yu-Xin Chen, Qi-Yu Chen, Jing-Shan Lu, Jinjun Wang, Keqiang Ye, Xu-Hui Li, Min Zhuo
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focused primarily on the homosynaptic
Externí odkaz:
https://doaj.org/article/d8c4a59128084beea6db2322f4ff0af6