Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Keola Beale"'
Autor:
Tony R. Reid, Nacer Abrouk, Scott Caroen, Bryan Oronsky, Meaghan Stirn, Christopher Larson, Keola Beale, Susan J. Knox, George Fisher
Publikováno v:
Clinical colorectal cancer.
RRx-001 is a novel cysteine-targeted alkylating agent that releases nitric oxide (NO). The primary biological activities of this hybrid molecule include macrophage repolarizing and vascular normalization. The purpose of this clinical trial (ROCKET) (
Autor:
Scott Caroen, George A. Fisher, Jan Scicinski, Keola Beale, Chan Clayton, Huy V. Nguyen, Cheryl D. Cho-Phan, Gary R. Fanger, Jennifer Carney, Chris Parker, Meaghan Stirn, Tony R. Reid, Susan J. Knox, Bryan Oronsky, Shoucheng Ning
Publikováno v:
Cancer Research. 75:A1-35
Background: RRx-001 is a novel systemically non-toxic pan-epigenetic modulator of DNA methyltransferases, Histone Deacetylases, and lysine demethylases with broad activity both preclinically and clinically. In the first-in-man Phase I trial, five pat