Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kenzie D MacIsaac"'
Autor:
Jianwu Bai, Steven L Smock, George R Jackson, Kenzie D MacIsaac, Yongsheng Huang, Courtney Mankus, Jonathan Oldach, Brian Roberts, Yu-Lu Ma, Joel A Klappenbach, Michael A Crackower, Stephen E Alves, Patrick J Hayden
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118286 (2015)
Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an in vitro air liquid interface cultured hu
Externí odkaz:
https://doaj.org/article/63cf64f8100649a6b70ec6bbe21137ad
Autor:
Kenzie D MacIsaac, Richard Baumgartner, Jia Kang, Andrey Loboda, Charles Peterfy, Julie DiCarlo, Jonathan Riek, Chan Beals
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113937 (2014)
UnlabelledApproximately 30% of rheumatoid arthritis patients achieve inadequate response to anti-TNF biologics. Attempts to identify molecular biomarkers predicting response have met with mixed success. This may be attributable, in part, to the varia
Externí odkaz:
https://doaj.org/article/e42dea54c54348b0965d86f0c496c5a4
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 4, p e1000773 (2010)
Understanding the mechanistic basis of transcriptional regulation has been a central focus of molecular biology since its inception. New high-throughput chromatin immunoprecipitation experiments have revealed that most regulatory proteins bind thousa
Externí odkaz:
https://doaj.org/article/70175d8770a342abb17402b66779bc8a
Autor:
Kenzie D MacIsaac, Ernest Fraenkel
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 4, p e36 (2006)
Externí odkaz:
https://doaj.org/article/8d5ad7fffbee4675bae745481b1a921f
Autor:
Yao Yao, Yi-Xin Zeng, Hans Bitter, Jeffrey Engelman, Peter S. Hammerman, Glenn Dranoff, Alan Huang, Bin Peng, En Li, Yuanyuan Zhao, Hongyun Zhao, Yan Huang, Wenfeng Fang, Jing Zhang, Peter Skewes-Cox, Lellean JeBailey, Viveksagar Krishnamurthy Radhakrishnan, Savina Jaeger, Yan Wang, Marc Pelletier, Yue Fan, Derek Y. Chiang, Kun Yu, Jason R. Dobson, Chunlin Xin, Pei-Yu Huang, Ting Zhou, Kenzie D. MacIsaac, Li Zhang
Supplementary tables Table S1: Patient characteristics. Table S2: Non-synonymous mutations for paired cohort. Table S3: Non-synonymous mutations for unpaired cohort. Table S4: Copy number variants. Table S5: Correlation of principal components with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b4b408144295ce41b86b706ab72f92
https://doi.org/10.1158/1541-7786.22516114
https://doi.org/10.1158/1541-7786.22516114
Autor:
Yao Yao, Yi-Xin Zeng, Hans Bitter, Jeffrey Engelman, Peter S. Hammerman, Glenn Dranoff, Alan Huang, Bin Peng, En Li, Yuanyuan Zhao, Hongyun Zhao, Yan Huang, Wenfeng Fang, Jing Zhang, Peter Skewes-Cox, Lellean JeBailey, Viveksagar Krishnamurthy Radhakrishnan, Savina Jaeger, Yan Wang, Marc Pelletier, Yue Fan, Derek Y. Chiang, Kun Yu, Jason R. Dobson, Chunlin Xin, Pei-Yu Huang, Ting Zhou, Kenzie D. MacIsaac, Li Zhang
Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV) associated cancer characterized by a poor prognosis and a high level of lymphocyte infiltrate. Genetic hallmarks of NPC are not completely known but include deletion of the p16 (CDKN2A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e754835a8df7589ee647249c5147345b
https://doi.org/10.1158/1541-7786.c.6541285
https://doi.org/10.1158/1541-7786.c.6541285
Autor:
Yao Yao, Yi-Xin Zeng, Hans Bitter, Jeffrey Engelman, Peter S. Hammerman, Glenn Dranoff, Alan Huang, Bin Peng, En Li, Yuanyuan Zhao, Hongyun Zhao, Yan Huang, Wenfeng Fang, Jing Zhang, Peter Skewes-Cox, Lellean JeBailey, Viveksagar Krishnamurthy Radhakrishnan, Savina Jaeger, Yan Wang, Marc Pelletier, Yue Fan, Derek Y. Chiang, Kun Yu, Jason R. Dobson, Chunlin Xin, Pei-Yu Huang, Ting Zhou, Kenzie D. MacIsaac, Li Zhang
Supplementary Figures Figure S1: Subtype identification using random sub-sampling. Figure S2: Subtype robustness. Figure S3: Morphological evaluation of tumors. Figure S4: % Tumor content by subtype. Figure S5: Principle components analysis. Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9e2829941a46f38dbf9e76e768e804
https://doi.org/10.1158/1541-7786.22516117
https://doi.org/10.1158/1541-7786.22516117
Autor:
Laura Engstrom, Kyle J. Piers, Kenneth Jay Barr, Renu Jain, Dallas C. Jones, Huseyin Mehmet, Heidi Ferguson, Gary D. Glick, John S. Mudgett, Richard Miller, Xiao Hu, Hongjun Zhang, I-Ming Wang, Abbas Hawwari, Craig C. Correll, Barbara Joyce-Shaikh, Razvan Cristescu, Yanxia Guo, Daniel J. Cua, Gretchen A. Baltus, Yi Chen, Thomas Daniel Aicher, Dennis M. Zaller, Laura L. Carter, Laxminarayan G Hegde, Kenzie D. MacIsaac
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+
Autor:
Huayang, Liu, Javad, Golji, Lauren K, Brodeur, Franklin S, Chung, Julie T, Chen, Rosalie S, deBeaumont, Caroline P, Bullock, Michael D, Jones, Grainne, Kerr, Li, Li, Daniel P, Rakiec, Michael R, Schlabach, Sosathya, Sovath, Joseph D, Growney, Raymond A, Pagliarini, David A, Ruddy, Kenzie D, MacIsaac, Joshua M, Korn, E Robert, McDonald
Publikováno v:
Nature medicine. 25(1)
Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant diseases
Publikováno v:
Drug Discovery Today. 19:133-139
The high failure rate of new therapeutic mechanisms tested in clinical development has spurred an upsurge in research dedicated to discovering biomarker readouts that can improve decision-making. Increasingly, systems biology and genomic technologies