Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kenyon G. Daniel"'
Autor:
Yuri Pevzner, Daniel N. Santiago, Jacqueline L. von Salm, Rainer S. Metcalf, Kenyon G. Daniel, Laurent Calcul, H. Lee Woodcock, Bill J. Baker, Wayne C. Guida, Wesley H. Brooks
Publikováno v:
AIMS Molecular Science, Vol 1, Iss 2, Pp 81-98 (2015)
Inherent biological viability and diversity of natural products make them a potentially rich source for new therapeutics. However, identification of bioactive compounds with desired therapeutic effects and identification of their protein targets is a
Externí odkaz:
https://doaj.org/article/8ec3a427478349328481da3736dbdd20
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2669c9313cc337efb62ae6e716345f5
https://doi.org/10.1002/0471266949.bmc280
https://doi.org/10.1002/0471266949.bmc280
Autor:
Wesley H. Brooks, Yuri Pevzner, Elza Pevzner, Kenyon G. Daniel, Wayne C. Guida, Mokenge P. Malafa
Publikováno v:
Clinical Oncology and Research. :1-8
In recent years, evidence has mounted that a particular form of vitamin E (its δ-tocotrienol variant) may have cellular functions beyond that of an antioxidant, a role commonly ascribed to the tocotrienol class of compounds. In particular, numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::545ffa80cd8b691e4df94d820bfea0e1
https://doi.org/10.31487/j.cor.2020.08.12
https://doi.org/10.31487/j.cor.2020.08.12
Autor:
Edna Gordian, Jiannong Li, Yuri Pevzner, Melanie Mediavilla-Varela, Kimberly Luddy, Kim Ohaegbulam, Kenyon G Daniel, Eric B Haura, Teresita Muñoz-Antonia
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114131 (2014)
Lung cancer is the second most common cancer and the leading cause of cancer-related deaths. Despite recent advances in the development of targeted therapies, patients with advanced disease remain incurable, mostly because metastatic non-small cell l
Externí odkaz:
https://doaj.org/article/7e42a4b873b24b1bab2cc7677f01f5d9
Autor:
Rebecca S Hesterberg, Matthew Beatty, Jessica M. McDaniel, Pearlie K. Epling-Burnette, Rainer Metcalf, Andreas Becker, Jeffrey A. Yoder, Ernst Schönbrunn, Rezaul M. Karim, Anjali M. Rajadhyaksha, Muhammad Ayaz, Kenyon G. Daniel, Aileen Y. Alontaga, Steven Gunawan, Yan Yang, Morgan E. Orobello, William E. Goodheart, Nicholas J. Lawrence, Afua A. Akuffo, Wayne C. Guida, Harshani R. Lawrence
Publikováno v:
Journal of Biological Chemistry. 293:6187-6200
Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction by engaging the DDB1–CUL4A–Roc1–RBX1 E3 ubiquitin ligase in human cells but not in mouse cells, sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f181fdb207955824e12db4c35f0aaa19
https://doi.org/10.1074/jbc.m117.816868
https://doi.org/10.1074/jbc.m117.816868
Publikováno v:
Analytical Biochemistry. 543:37-42
Digestion techniques for ICP analysis have been poorly studied for biological samples. This report describes an optimized method for analysis of trace metals that can be used across a variety of sample types. Digestion methods were tested and optimiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11768728d44642b111e5ddfb61a9518a
https://doi.org/10.1016/j.ab.2017.11.016
https://doi.org/10.1016/j.ab.2017.11.016
Autor:
Kenyon G. Daniel, Wesley H. Brooks, Wayne C. Guida, Robert P. Sparks, Rainer Metcalf, Sreya Mukherjee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3826-3829
It has been found that tumor cells and tissues, compared to normal cells, have higher levels of copper and possibly other metal ions. This presents a potential vulnerability of tumor cells that can serve as a physiological difference between cancer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f8f3cf1e6203523529e122c5ae82e5
https://doi.org/10.1016/j.bmcl.2016.04.075
https://doi.org/10.1016/j.bmcl.2016.04.075
Autor:
Wayne C. Guida, Wesley H. Brooks, H. Lee Woodcock, Jacqueline L. von Salm, Rainer Metcalf, Daniel N. Santiago, Bill J. Baker, Laurent Calcul, Kenyon G. Daniel, Yuri Pevzner
Publikováno v:
AIMS Molecular Science, Vol 1, Iss 2, Pp 81-98 (2015)
AIMS Molecular Science, Vol 1, Iss 2, Pp 81-98 (2014)
AIMS Molecular Science, Vol 1, Iss 2, Pp 81-98 (2014)
Inherent biological viability and diversity of natural products make them a potentially rich source for new therapeutics. However, identification of bioactive compounds with desired therapeutic effects and identification of their protein targets is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc17aa46f51785534e74de830e5ba655
http://www.aimspress.com/article/10.3934/molsci.2014.2.81/fulltext.html
http://www.aimspress.com/article/10.3934/molsci.2014.2.81/fulltext.html
Publikováno v:
Expert Opinion on Therapeutic Patents. 24:369-382
Over the past 3 years, numerous patents and patent applications have been submitted and published involving compounds designed to inhibit the proteasome. Proteasome inhibition has been of great interest in cancer research since disruption of proteoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53470bb4106c47dee5c3c4a1cf600bc1
https://doi.org/10.1517/13543776.2014.877444
https://doi.org/10.1517/13543776.2014.877444
Autor:
Anna Kharitonova, Grace A. Binder, Kenyon G. Daniel, Christine S. Gambino, Rainer Metcalf, Wayne C. Guida
Publikováno v:
Cancer Research. 79:6-6
Stimulator of interferon genes (STING) is a receptor protein involved in the propagation of innate immune sensing of cytosolic DNA through the production of IFN-β. Mechanistic studies have shown IFN-β production within the tumor microenvironment ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc9ca9311cf2f8e9c0b9758a6568aeb
https://doi.org/10.1158/1538-7445.am2019-6
https://doi.org/10.1158/1538-7445.am2019-6