Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment

Autor: Kenyaita M. Hodge, Amber A. Burt, Marie Camerota, Brian S. Carter, Jennifer Check, Karen N. Conneely, Jennifer Helderman, Julie A. Hofheimer, Anke Hüls, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Carmen J. Marsit, Barry M. Lester, Todd M. Everson

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract The time from conception through the first year of life is the most dynamic period in human development. This time period is particularly important for infants born very preterm (

Externí odkaz: https://doaj.org/article/00ebc431d2c24149985591644f345a5d

Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel DiseaseSummary

Autor: Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 667-682 (2021)

Background & Aims: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress

Externí odkaz: https://doaj.org/article/5ea732da22e64125aa7a08b992a12fda

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

Autor: Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F. A. Grant

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in

Externí odkaz: https://doaj.org/article/068349a3f36f4d3abaa72dceb7f71f4a

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

Autor: Jonathan P. Bradfield, Benjamin F. Voight, Chun Su, Kenyaita M. Hodge, Claudia A. Doege, Rick Rausch, Robert I. Berkowitz, Struan F.A. Grant, Diana L. Cousminer, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Alisha Basak, Maria Caterina De Rosa, Matthew C. Pahl, James A. Pippin, Sheridan H. Littleton, Rudolph L. Leibel, Keith Boehm, Andrew D. Wells, Reza K. Hammond, Chiara Lasconi, Alessandra Chesi

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine systems. Given its role governing key traits, such as body weight and reproductive timing, understanding the genetic regulation of hypothalamic development and fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9343345b059b7546f74426e5b0e81c
https://doi.org/10.1530/ey.19.1.2

Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia

Autor: David I. W. Phillips, Alice Holmes, Hannah F. Wilson, Tanwi Vartak, Diana L. Cousminer, Arla Gamper, Kenyaita M. Hodge, Kim Lorenz, Samuel T. Jerram, Stanley Schwartz, Elisabeth R. Trimble, Alistair J K Williams, Shitaye Alemu Balcha, Abayneh Girma Demisse, R. David Leslie, Struan F.A. Grant, Rajashree Mishra, Benjamin F. Voight

Publikováno v: Diabetologia
Balcha, S A, Demisse, A G, Mishra, R, Vartak, T, Cousminer, D L, Hodge, K M, Voight, B F, Lorenz, K, Schwartz, S, Jerram, S T, Gamper, A, Holmes, A, Wilson, H F, Williams, A J K, Grant, S F A, Leslie, R D, Phillips, D I W & Trimble, E R 2020, ' Type 1 diabetes in Africa : an immunogenetic study in the Amhara of North-West Ethiopia ', Diabetologia . https://doi.org/10.1007/s00125-020-05229-x
Balcha, S A, Demisse, A G, Mishra, R, Vartak, T, Cousminer, D L, Hodge, K M, Voight, B F, Lorenz, K, Schwartz, S, Jerram, S T, Gamper, A, Holmes, A, Wilson, H F, Williams, A J K, Grant, S F A, Leslie, R D, Phillips, D I W & Trimble, E R 2020, ' Type 1 diabetes in Africa an immunogenetic study in the Amhara of North-West Ethiopia ', Diabetologia, vol. 63, no. 10, pp. 2158-2168 . https://doi.org/10.1007/s00125-020-05229-x

Aims/hypothesis We aimed to characterise the immunogenic background of insulin-dependent diabetes in a resource-poor rural African community. The study was initiated because reports of low autoantibody prevalence and phenotypic differences from Europ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7630a1051fb351796c4213a9e2aeb1d
http://europepmc.org/articles/PMC7476916