Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Kenya Honda"'
Autor:
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Diabetes is known to increase the risk of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Here we treat male STAM (STelic Animal Model) mice, which develop diabetes, NASH and HCC associated with dysbiosis upon low-dos
Externí odkaz:
https://doaj.org/article/00518db0b90f431a9f78d36478f351e5
Autor:
Etsushi Toyofuku, Kozue Takeshita, Hidenori Ohnishi, Yuko Kiridoshi, Hiroaki Masuoka, Tomonori Kadowaki, Ryuta Nishikomori, Kenichi Nishimura, Chie Kobayashi, Takasuke Ebato, Tomonari Shigemura, Yuzaburo Inoue, Wataru Suda, Masahira Hattori, Tomohiro Morio, Kenya Honda, Hirokazu Kanegane
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
IntroductionHaploinsufficiency of A20 (HA20) is a form of inborn errors of immunity (IEI). IEIs are genetically occurring diseases, some of which cause intestinal dysbiosis. Due to the dysregulation of regulatory T cells (Tregs) observed in patients
Externí odkaz:
https://doaj.org/article/7def3c4cc537413ba58d2b7e13017a76
Autor:
Kosuke Miyauchi, Sewon Ki, Masao Ukai, Yoshie Suzuki, Kentaro Inoue, Wataru Suda, Takeshi Matsui, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko J. Tanaka, Mariko Okada-Hatakeyama, Masato Kubo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dominant-negative mutations associated with signal transducer and activator of transcription 3 (STAT3) signaling, which controls epithelial proliferation in various tissues, lead to atopic dermatitis in hyper IgE syndrome. This dermatitis is thought
Externí odkaz:
https://doaj.org/article/4dcb772a5cd84371b7a0171122d63e7a
Autor:
Manabu Nagayama, Tomonori Yano, Koji Atarashi, Takeshi Tanoue, Mariko Sekiya, Yasutoshi Kobayashi, Hirotsugu Sakamoto, Kouichi Miura, Keijiro Sunada, Takaaki Kawaguchi, Satoru Morita, Kayoko Sugita, Seiko Narushima, Nicolas Barnich, Jun Isayama, Yuko Kiridooshi, Atsushi Shiota, Wataru Suda, Masahira Hattori, Hironori Yamamoto, Kenya Honda
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Dysbiotic microbiota contributes to the pathogenesis of Crohn’s disease (CD) by regulating the immune system. Although pro-inflammatory microbes are probably enriched in the small intestinal (SI) mucosa, most studies have focused on fecal microbiot
Externí odkaz:
https://doaj.org/article/00333b856e3b490c98abe9e52815416e
Autor:
Hitoshi Tsugawa, Yasuaki Kabe, Ayaka Kanai, Yuki Sugiura, Shigeaki Hida, Shun’ichiro Taniguchi, Toshio Takahashi, Hidenori Matsui, Zenta Yasukawa, Hiroyuki Itou, Keiyo Takubo, Hidekazu Suzuki, Kenya Honda, Hiroshi Handa, Makoto Suematsu, Matthew K. Waldor
Publikováno v:
PLoS Biology, Vol 18, Iss 9 (2020)
Short-chain fatty acids (SCFAs) produced by gastrointestinal microbiota regulate immune responses, but host molecular mechanisms remain unknown. Unbiased screening using SCFA-conjugated affinity nanobeads identified apoptosis-associated speck-like pr
Externí odkaz:
https://doaj.org/article/56f120bff45342348320ad7fc691a85d
Autor:
Kazuyuki Kasahara, Takeshi Tanoue, Tomoya Yamashita, Keiko Yodoi, Takuya Matsumoto, Takuo Emoto, Taiji Mizoguchi, Tomohiro Hayashi, Naoki Kitano, Naoto Sasaki, Koji Atarashi, Kenya Honda, Ken-ichi Hirata
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 3, Pp 519-528 (2017)
The gut microbiota were shown to play critical roles in the development of atherosclerosis, but the detailed mechanism is limited. The purpose of this study is to clarify the influence of gut microbiota on atherogenesis via lipid metabolism and syste
Externí odkaz:
https://doaj.org/article/8831c1e3e4f140dd932af9c729781a4a
Autor:
Ho Namkoong, Makoto Ishii, Hideki Fujii, Kazuma Yagi, Takahiro Asami, Takanori Asakura, Shoji Suzuki, Ahmed E Hegab, Hirofumi Kamata, Sadatomo Tasaka, Koji Atarashi, Nobuhiro Nakamoto, Satoshi Iwata, Kenya Honda, Takanori Kanai, Naoki Hasegawa, Shigeo Koyasu, Tomoko Betsuyaku
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006955 (2018)
Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of my
Externí odkaz:
https://doaj.org/article/18673713073147ecbc69655bcc50456a
Autor:
Richard R Stein, Takeshi Tanoue, Rose L Szabady, Shakti K Bhattarai, Bernat Olle, Jason M Norman, Wataru Suda, Kenshiro Oshima, Masahira Hattori, Georg K Gerber, Chris Sander, Kenya Honda, Vanni Bucci
Publikováno v:
eLife, Vol 7 (2018)
Manipulation of the gut microbiota holds great promise for the treatment of diseases. However, a major challenge is the identification of therapeutically potent microbial consortia that colonize the host effectively while maximizing immunologic outco
Externí odkaz:
https://doaj.org/article/f7c2a82e817f466bb137c0d58c064ec5
Autor:
Takehiro Kamo, Hiroshi Akazawa, Wataru Suda, Akiko Saga-Kamo, Yu Shimizu, Hiroki Yagi, Qing Liu, Seitaro Nomura, Atsuhiko T Naito, Norifumi Takeda, Mutsuo Harada, Haruhiro Toko, Hidetoshi Kumagai, Yuichi Ikeda, Eiki Takimoto, Jun-Ichi Suzuki, Kenya Honda, Hidetoshi Morita, Masahira Hattori, Issei Komuro
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174099 (2017)
Emerging evidence has suggested a potential impact of gut microbiota on the pathophysiology of heart failure (HF). However, it is still unknown whether HF is associated with dysbiosis in gut microbiota. We investigated the composition of gut microbio
Externí odkaz:
https://doaj.org/article/4ed727384dff485d8925ece0e435b31f
Autor:
Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000514 (2009)
Host defense against the intracellular protozoan parasite Trypanosoma cruzi depends on Toll-like receptor (TLR)-dependent innate immune responses. Recent studies also suggest the presence of TLR-independent responses to several microorganisms, such a
Externí odkaz:
https://doaj.org/article/64aea5641a344053a19379e5803f39d4