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of 79
pro vyhledávání: '"Kenya, Shitara"'
Supplementary Table 2 from Ligand-Specific Antibodies to Insulin-Like Growth Factors Suppress Intestinal Polyp Formation in Apc+/− Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06874f554dc59b495cac53f91d1d3b85
https://doi.org/10.1158/1535-7163.22484729
https://doi.org/10.1158/1535-7163.22484729
Supplementary Figure 1 from Ligand-Specific Antibodies to Insulin-Like Growth Factors Suppress Intestinal Polyp Formation in Apc+/− Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bdf1ba12d3d70cac1e0367fbf44059
https://doi.org/10.1158/1535-7163.22484735
https://doi.org/10.1158/1535-7163.22484735
Insulin-like growth factors (IGF-I and IGF-II) play important roles in intestinal tumorigenesis. To investigate the effectiveness of IGF-targeting strategies, we conducted an in vivo study using anti-mouse neutralizing antibodies IGF-I (KM3168) and I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d918b692672db928f7bbf87e1c677cd
https://doi.org/10.1158/1535-7163.c.6531554.v1
https://doi.org/10.1158/1535-7163.c.6531554.v1
Autor:
Tatsuo Morita, Naoki Shimada, Masaya Obayashi, Kenya Shitara, Kenji Komatsu, Hirotoshi Kawata, Tomoko Kamiakito, Akira Tanaka, Toshio Ota
Publikováno v:
The Prostate. 72:1071-1079
BACKGROUND Endocrine resistance is a critical issue in managing patients with prostate cancer. This study is undertaken to search for a potential molecular target connected with this process using a model system of androgen-dependent and androgen-unr
Autor:
Kenya Shitara, Ryo Iwamoto, Fusanori Yotsumoto, Shingo Miyamoto, Sayaka Hori, Eisuke Mekada, Kumiko Takahashi, Tomoko Yoneda, Hiroshi Yagi, Hiroshi Ando, Miki Hamaoka, Yuka Sasaki, Takuya Murakami, Akiko Furuya
Publikováno v:
Clinical Cancer Research. 17:6733-6741
Purpose: Heparin-binding epidermal growth factor (EGF)–like growth factor (HB-EGF) is a member of the EGF family and plays a pivotal role in tumor progression in ovarian cancer. We developed an anti-HB-EGF monoclonal antibody (mAb) and investigated
Publikováno v:
Molecular Cancer Therapeutics. 9:419-428
Insulin-like growth factors (IGF-I and IGF-II) play important roles in intestinal tumorigenesis. To investigate the effectiveness of IGF-targeting strategies, we conducted an in vivo study using anti-mouse neutralizing antibodies IGF-I (KM3168) and I
Autor:
Shingo Kakita, Mitsuo Satoh, Shigeru Iida, Koichi Kato, Yutaka Kanda, Seiji Saitou, Kenya Shitara, Mami Shibata-Koyama, Akira Okazaki, Katsuhiro Mori, Kazuko Kitajima-Miyama
Publikováno v:
Glycobiology
Human leukocyte receptor IIIa (Fc gamma RIIIa) plays an important role in mediating therapeutic antibodies' antibody-dependent cellular cytotoxicity (ADCC), which is closely related to the clinical efficacy of anticancer processes in humans in vivo.
Autor:
Kenya Shitara, Kazuko Kitajima, Mitsuo Satoh, So Ohta, Masako Wakitani, Tomoaki Nakagawa, Akito Natsume, Mika In, Rinpei Niwa, Yukiko Shimizu, Hiroyuki Takamura
Publikováno v:
Cancer Research. 68:3863-3872
Enhancement of multiple effector functions of an antibody may be a promising approach for antibody therapy. We have previously reported that fucose removal from Fc-linked oligosaccharides greatly enhances antibody-dependent cellular cytotoxicity (ADC
Autor:
Kenya Shitara, Sato Takashi, Hiroshi Ando, Sachiko Kodama-Nishida, So Ohta, Kenji Shibata, Takefumi Matsushita, Masako Wakitani
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:1739-1744
Tn-antigen (alpha-N-acetyl-galactosamine(GalNAc)-Ser/Thr) is a cancer-associated carbohydrate antigen expressed in various epithelial and hematological cancers, and although a number of anti-Tn IgG and IgM antibodies have been generated, they have no
Autor:
Masato Kobori, Chie Goto, Yuji Ohki, Kenya Shitara, Rie Tajima, Ayşe Tansu Koparal, Kazuhiro Toriyama, Tomoaki Niimi, Shuhei Torii, Hironobu Yamashita, Ryo Narita, Yasuo Kitagawa
Publikováno v:
Development, Growth & Differentiation. 50:97-107
Cleavage of the extracellular matrix (ECM) by proteolysis unmasks cryptic sites and generates novel fragments with biological activities functionally distinct from those of the intact ECM molecule. The laminin G-like (LG)4-5 fragment has been shown t