Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kenton T. Woodard"'
Autor:
John Paul Gaylor, Katharine J. Liang, Kenton T. Woodard, Mark A. Weaver, R. Jude Samulski, Ellen R. Weiss
Publikováno v:
Molecular Therapy. 25:765-779
NRF2 is a transcription factor that drives antioxidant gene expression in multiple organ systems. We hypothesized that Nrf2 overexpression could be therapeutically applied toward diseases in which redox homeostasis is disrupted. In this study, adeno-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e277a1ba797a796baa785e4aafbac2
https://doi.org/10.1016/j.ymthe.2016.12.016
https://doi.org/10.1016/j.ymthe.2016.12.016
Autor:
Richard Jude Samulski, Matthew L. Hirsch, Chengwen Li, M Wang, Kenton T. Woodard, A Crosby, Junjiang Sun
Publikováno v:
Gene therapy
Recent hemophilia B clinical trials using adeno-associated virus (AAV) gene delivery have demonstrated much lower coagulation factor IX (FIX) production in patients compared with the high levels observed in animal models and AAV capsid-specific cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfb66591ebcb7ab504259e39865b2d4
https://doi.org/10.1038/gt.2016.75
https://doi.org/10.1038/gt.2016.75
Publikováno v:
Journal of Virology. 90:9878-9888
Many adeno-associated virus (AAV) serotypes efficiently transduce the retina when delivered to the subretinal space but show limited success when delivered to the vitreous due to the inner limiting membrane (ILM). Subretinal delivery of AAV serotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b61750772160c3b0962a21f8a8e92c
https://doi.org/10.1128/jvi.01568-16
https://doi.org/10.1128/jvi.01568-16
Autor:
R. C. Spike, Paul D. Ross, Kenton T. Woodard, Sahana Nagabhushan Kalburgi, Mark E.S. Bailey, Stuart Cobb, Anne E. West, Kamal Ke Gadalla, R. Jude Samulski, Jie V. Deng, Steven J. Gray, Lavanya Bachaboina
Publikováno v:
Molecular Therapy. 21(1):18-30
Typical Rett syndrome (RTT) is a pediatric disorder caused by loss-of-function mutations in the methyl-CpG binding protein 2 (MECP2) gene. The demonstrated reversibility of RTT-like phenotypes in mice suggests that MECP2 gene replacement is a potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ffe00d1f7c3f206fd17eb6727dac52
Autor:
Aravind Asokan, Telmo Llanga, Giridhar Murlidharan, Brian C. Gilger, Neil C Chungfat, Joanne Kurtzberg, R. Jude Samulski, William D. Bennett, Kenton T. Woodard, Matthew L. Hirsch, Melisa Vance
Publikováno v:
Scientific Reports
Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92aa5a04b6b2a90fb05e2b6f3380eee4
http://europepmc.org/articles/PMC4761992
http://europepmc.org/articles/PMC4761992
Publikováno v:
Therapeutic Delivery. 1:517-534
This review aims to provide a broad overview of the targets, challenges and potential for gene therapy in the CNS, citing specific examples. There are a broad range of therapeutic targets, with very different requirements for a suitable viral vector.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554e0fb7623c520db5e2fd05a7ec563e
https://doi.org/10.4155/tde.10.50
https://doi.org/10.4155/tde.10.50
Publikováno v:
Molecular Therapy. 24:S217-S218
AAV gene therapy has demonstrated success for the treatment of several ocular diseases with the tropism and efficiency of AAV retinal transduction being a function of the route of administration. Subretinal injection has been the primary route to del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84695569880a12c65c871704e1e6180
https://doi.org/10.1016/s1525-0016(16)33352-4
https://doi.org/10.1016/s1525-0016(16)33352-4
Publikováno v:
Journal of morphology. 273(2)
Adult urodele amphibians possess extensive regenerative abilities, including lens, jaws, limbs, and tails. In this study, we examined the cellular events and time course of spinal cord regeneration in a species, Plethodon cinereus, that has the abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223d30f02e3016018aaacd615b2a4ea5
https://pubmed.ncbi.nlm.nih.gov/21956379
https://pubmed.ncbi.nlm.nih.gov/21956379