Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Kento Koketsu"'
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Efficient production of lacto-N-fucopentaose III in engineered Escherichia coli using α1,3-fucosyltransferase from Parabacteroides goldsteinii
Autor: Tomotoshi Sugita, Sotaro Sampei, Kento Koketsu
Publikováno v: Journal of biotechnology.
Lacto-N-fucopentaose III (LNFP III) is a human milk oligosaccharide (HMO) with potential health benefits in infants, including in immune development and modulation of the intestinal environment. Low-cost fermentative production of various HMOs from l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a12304e7052341c15c1b0e23347cca
https://pubmed.ncbi.nlm.nih.gov/36509384
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Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3
Autor: Ryo Tanifuji, Ryutaro Asano, Hiroki Oguri, Kento Koketsu, Michiko Takakura, Hideaki Oikawa, Atsushi Minami
Publikováno v: Journal of the American Chemical Society. 140:10705-10709
The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet-Spengler cyclizations. Herein we report concise and divergent chemo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd55d42b68b0ec961f11d794955eaad5
https://doi.org/10.1021/jacs.8b07161
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5
Ectoine hydroxylase displays selective trans-3-hydroxylation activity towards L-proline
Autor: Takeyuki Nishikawa, Ryotaro Hara, Kento Koketsu, Kuniki Kino, Takuya Okuhara
Publikováno v: Applied microbiology and biotechnology. 103(14)
l-Hydroxyproline (Hyp) is a valuable intermediate for the synthesis of pharmaceuticals; consequently, a practical process for its production has been in high demand. To date, industrial processes have been developed by using l-Pro hydroxylases. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497dd5d423fe789de8289c60013fc73f
https://pubmed.ncbi.nlm.nih.gov/31106391
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6
Catalytic asymmetric synthesis of the common amino acid component in the biosynthesis of tetrahydroisoquinoline alkaloids
Autor: Ryo Tanifuji, Hiroki Oguri, Yuki Yoshinaga, Kento Koketsu, Atsushi Minami, Hideaki Oikawa
Publikováno v: Tetrahedron Letters. 57:623-626
Biosynthetic assembly lines of tetrahydroisoquinoline alkaloids employ the tyrosine derivative, ( S )-2-amino-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoic acid, as a common amino acid building block. A catalytic asymmetric synthetic route to the c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6ec5c62b23ec87727e5fafd1a57b9ff
https://doi.org/10.1016/j.tetlet.2015.12.110
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7
Core Assembly Mechanism of Quinocarcin/SF-1739: Bimodular Complex Nonribosomal Peptide Synthetases for Sequential Mannich-type Reactions
Autor: Kento Koketsu, Kenji Watanabe, Shunsuke Kaneko, Chiaki Yamazaki, Tomoshige Hiratsuka, Hideaki Oikawa, Atsushi Minami, Hiroki Oguri
Publikováno v: Chemistry & Biology. 20:1523-1535
SummaryQuinocarcin and SF-1739, potent antitumor antibiotics, share a common tetracyclic tetrahydroisoquinoline (THIQ)-pyrrolidine core scaffold. Herein, we describe the identification of their biosynthetic gene clusters and biochemical analysis of Q
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f771de95efe15d87f65d36069bbaa27
https://doi.org/10.1016/j.chembiol.2013.10.011
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8
Identification of Homophenylalanine Biosynthetic Genes from the Cyanobacterium Nostoc punctiforme PCC73102 and Application to Its Microbial Production by Escherichia coli
Autor: Satoshi Mitsuhashi, Kazuhiko Tabata, Kento Koketsu
Publikováno v: Applied and Environmental Microbiology. 79:2201-2208
l-Homophenylalanine ( l -Hph) is a useful chiral building block for synthesis of several drugs, including angiotensin-converting enzyme inhibitors and the novel proteasome inhibitor carfilzomib. While the chemoenzymatic route of synthesis is fully de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca18f8be4abbdc497ed0e0d62eed0cf
https://doi.org/10.1128/aem.03596-12
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9
Enzymatic Macrolactonization in the Presence of DNA Leading to Triostin A Analogs
Autor: Hideaki Oikawa, Kenji Watanabe, Hiroki Oguri, Kento Koketsu
Publikováno v: Chemistry & Biology. 15(8):818-828
SummaryExcised thioesterase domains are versatile catalysts for macrocyclization. However, thioesterase-catalyzed cyclization is often precluded due to the occurrence of hydrolysis and product inhibition. To circumvent these obstacles, we devised an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12775b51a5a05156b1bfefc10f4a8dd7
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10
Refined regio- and stereoselective hydroxylation of L-pipecolic acid by protein engineering of L-proline cis-4-hydroxylase based on the X-ray crystal structure
Autor: Yasuhito Shomura, Kento Koketsu, Kuniki Kino, Kei Moriwaki, Mikiro Hayashi, Ryotaro Hara, Yoshiki Higuchi, Satoshi Mitsuhashi
Publikováno v: ACS synthetic biology. 4(4)
Enzymatic regio- and stereoselective hydroxylation are valuable for the production of hydroxylated chiral ingredients. Proline hydroxylases are representative members of the nonheme Fe(2+)/α-ketoglutarate-dependent dioxygenase family. These enzymes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9144852991fa89865cd54181882603cc
https://pubmed.ncbi.nlm.nih.gov/25171735
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