Review: Current trends, challenges, and success stories in adjuvant research

Autor: Kentner L. Singleton, Ari Joffe, Wolfgang W. Leitner

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Vaccine adjuvant research is being fueled and driven by progress in the field of innate immunity that has significantly advanced in the past two decades with the discovery of countless innate immune receptors and innate immune pathways. Receptors for

Externí odkaz: https://doaj.org/article/a16362eb86234c16bd9584cb40d0c035

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Autor: Xiongtao Ruan, Sin Lih Tan, Danielle J Clark, Clementine Massoue, Harry Thompson, Christoph Wülfing, Pamela L. Schwartzberg, A. J. Hedges, Paul Verkade, Minna Du, Kentner L. Singleton, Robert F. Murphy, Gaia Bellomo, Laura E. McMillan, Lidiya Mykhaylechko, Dominic Alibhai

Publikováno v: Clark, D J, McMillan, L E, Tan, S L, Bellomo, G, Massoue, C, Thompson, H, Mykhaylechko, L, Alibhai, D, Ruan, X, Singleton, K L, Du, M, Hedges, A, Schwartzberg, P L, Verkade, P, Murphy, R F & Wuellfing, C 2019, ' Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion ', eLife, vol. 8, e45789 . https://doi.org/10.7554/eLife.45789
eLife, Vol 8 (2019)
Clark, D J, McMillan, L E, Tan, S L, Bellomo, G, Thompson, H F, Alibhai, D R, Hedges, A J, Verkade, P & Wuelfing, C 2019, ' Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion ', eLife . https://doi.org/10.7554/eLife.45789
eLife

Supramolecular signaling assemblies are of interest for their unique signaling properties. A µm scale signaling assembly, the central supramolecular signaling cluster (cSMAC), forms at the center of the interface of T cells activated by antigen-pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4774c6b48f369885de15c659882737ae
https://hdl.handle.net/1983/fcd0794f-3d1a-414e-bfae-6181ba720761

Author response: Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Autor: Sin Lih Tan, Danielle J Clark, Harry Thompson, Lidiya Mykhaylechko, Laura E. McMillan, A. J. Hedges, Xiongtao Ruan, Minna Du, Paul Verkade, Robert F. Murphy, Kentner L. Singleton, Pamela L. Schwartzberg, Dominic Alibhai, Christoph Wülfing, Gaia Bellomo, Clementine Massoue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a9afccd52255e90b118b293a2ed56c1
https://doi.org/10.7554/elife.45789.044

A Large T Cell Invagination with CD2 Enrichment Resets Receptor Engagement in the Immunological Synapse

Autor: Christopher J. Gilpin, Christoph Wülfing, Kenneth S. Chen, Nadia Parvaze, Mark M. Davis, Michael D. Sjaastad, Kentner L. Singleton, Kavyya R. Dama, Paula Jennings, Bozidar Purtic

Publikováno v: The Journal of Immunology. 177:4402-4413

T cell activation is driven by the TCR and complemented by costimulation. We have studied the dynamics of ligand-engagement of the costimulatory receptor CD2 in T cell/APC couples. Thousands of ligand-engaged CD2 molecules were included in a large T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a28fdcb051fccfbe531694fe6e4a0897
https://doi.org/10.4049/jimmunol.177.7.4402

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

Autor: Kole T. Roybal, Nicolai S. C. van Oers, Christoph Wülfing, Guo Fu, Yi Sun, Nicholas R. J. Gascoigne, Kentner L. Singleton

Publikováno v: Science Signaling. 2

Temporal and spatial variations in the concentrations of signaling intermediates in a living cell are important for signaling in complex networks because they modulate the probabilities that signaling intermediates will interact with each other. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f3e8af8b758175b25abe0007ba33de
https://doi.org/10.1126/scisignal.2000199