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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Kaisinger, L, Kentistou, K, Stankovic, S, Gardner, E, Day, F, Zhao, Y, Mörseburg, A, Carnie, C, Zagnoli-Vieira, G, Puddu, F, Jackson, S, O'Rahilly, S, Farooqi, S, Dearden, L, Pantaleão, L, Ozanne, S, Ong, K, Perry, John
Obesity contributes substantially to the global burden of disease and has a significant heritable component. Recent large-scale exome sequencing studies identified several genes in which rare, protein-coding, variants have large effects on adult body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a60428af9822e81887bd069211c7c3
https://www.repository.cam.ac.uk/handle/1810/353620
https://www.repository.cam.ac.uk/handle/1810/353620
Autor:
Graham, Sarah E, Clarke, Shoa L, Wu, Kuan-Han H, Kanoni, Stavroula, Zajac, Greg JM, Ramdas, Shweta, Surakka, Ida, Ntalla, Ioanna, Vedantam, Sailaja, Winkler, Thomas W, Locke, Adam E, Marouli, Eirini, Hwang, Mi Yeong, Han, Sohee, Narita, Akira, Choudhury, Ananyo, Bentley, Amy R, Ekoru, Kenneth, Verma, Anurag, Trivedi, Bhavi, Martin, Hilary C, Hunt, Karen A, Hui, Qin, Klarin, Derek, Zhu, Xiang, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F, Holm, Hilma, Olafsson, Isleifur, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M, Rasheed, Humaira, Ruotsalainen, Sanni E, Havulinna, Aki S, Veturi, Yogasudha, Feng, QiPing, Rosenthal, Elisabeth A, Lingren, Todd, Pacheco, Jennifer Allen, Pendergrass, Sarah A, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E, Campbell, Archie, Lin, Kuang, Millwood, Iona Y, Hindy, George, Rasheed, Asif, Faul, Jessica D, Zhao, Wei, Weir, David R, Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Mahajan, Anubha, Brown, Michael R, Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M, Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Willemsen, Gonneke, Wood, Andrew R, Ji, Yingji, Gao, Zishan, Haworth, Simon, Mitchell, Ruth E, Chai, Jin Fang, Aadahl, Mette, Yao, Jie, Manichaikul, Ani, Warren, Helen R, Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L, Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Sidore, Carlo, Fiorillo, Edoardo, McDaid, Aaron F, Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T, Thuesen, Betina H, Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Daw, E Warwick, Zmuda, Joseph M, Mitchell, Jonathan S, Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A, Feitosa, Mary F, Wojczynski, Mary K, Preuss, Michael, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W, Engmann, Jorgen, Kember, Rachel L, Slieker, Roderick C, Lo, Ken Sin, Zilhao, Nuno R, Le, Phuong, Kleber, Marcus E, Delgado, Graciela E, Huo, Shaofeng, Ikeda, Daisuke D, Iha, Hiroyuki, Yang, Jian, Liu, Jun, Leonard, Hampton L, Marten, Jonathan, Schmidt, Börge, Arendt, Marina, Smyth, Laura J, Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Ahmed, Meraj, Jackson, Anne U, Irvin, Marguerite R, Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul RHJ, Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A, Chai, Xiaoran, Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N, Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C, Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Hung, Yi-Jen, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A, Gorski, Mathias, Brumat, Marco, Meidtner, Karina, Bielak, Lawrence F, Smith, Jennifer A, Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Xue, Chao, Zhang, Jifeng, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J, Pitkänen, Niina, Cade, Brian E, Lee, Jiwon, van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Zimmermann, Martina E, Lee, Jong Young, Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W, Wang, Carol A, Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hildalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O, van Setten, Jessica, Li, Xiaoyin, Schwander, Karen, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D, Reiner, Alexander P, Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Highland, Heather M, Young, Kristin L, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C, Nadkarni, Girish N., Launer, Lenore J, Li, Huaixing, Nalls, Mike A, Raitakari, Olli T, Ichihara, Sahoko, Wild, Sarah H, Nelson, Christopher P, Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S, Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, Bhatti, Konain Fatima, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H.H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W, Kraaijeveld, Adriaan O, Beulens, Joline WJ, Shu, Xiao-Ou, Rallidis, Loukianos S, Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W, Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii-Der Ida, Pennell, Craig E, Mori, Trevor A, Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M, Stark, Klaus J, Völzke, Henry, Homuth, Georg, Evans, Michele K, Zonderman, Alan B, Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E, Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J, Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Chen, Y Eugene, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon LR, Kato, Norihiro, Schulze, Matthias B, Girotto, Giorgia, Jung, Bettina, Böger, Carsten A, Joshi, Peter K, Bennett, David A, De Jager, Philip L, Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J, Munroe, Patricia B, Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J, Chasman, Daniel I., Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A, Adair, Linda S, Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R, Krauss, Ronald M, Wu, Jer-Yuarn, Zheng, Wei, den Hollander, Anneke I, Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G, Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E, Golightly, Yvonne M, Wilson, James F, Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J, Rao, D C, Arnett, Donna K, Walker, Mark, Koistinen, Heikki A, Chandak, Giriraj R, Yajnik, Chittaranjan S, Mercader, Josep M, Tusie-Luna, Teresa, Aguilar-Salinas, Carlos, Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, E Shyong, van Dam, Rob M, Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F, McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I, Palmer, Colin NA, Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M, Lu, Fan, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Parra, Esteban J, Cruz, Miguel, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, Hart, Leen M t, Elders, Petra JM, Rader, Daniel J, Damrauer, Scott M, Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D, Loos, Ruth J.F., Province, Michael A, Psaty, Bruce M, Brandslund, Ivan, Pramstaller, Peter P, Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F.A., Kiemeney, Lambertus ALM, de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W, Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V, Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Cucca, Francesco, Mook-Kanamori, Dennis O, van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P, Grarup, Niels, Sever, Peter, Poulter, Neil, Rotter, Jerome I, Dantoft, Thomas M, Karpe, Fredrik, Neville, Matt J, Timpson, Nicholas J, Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T, Pedersen, Nancy L, Magnusson, Patrik KE, Boomsma, Dorret I, de Geus, Eco JC, Cupples, L Adrienne, van Meurs, Joyce B.J., Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J, Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C, Kooner, Jaspal S, de Vries, Paul S, Morrison, Alanna C, North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G, Whitfield, John B, Abbas, Shahid, Saleheen, Danish, Walters, Robin G, Holmes, Michael V, Black, Corri, Smith, Blair H, Justice, Anne E, Baras, Aris, Buring, Julie E, Ridker, Paul M, Chasman, Daniel I, Kooperberg, Charles, Wei, Wei-Qi, Jarvik, Gail P, Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D, Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Thorsteinsdottir, Unnur, Stefansson, Kari, Ho, Yuk-Lam, Lynch, Julie A, Rader, Daniel, Tsao, Phil S, Chang, Kyong-Mi, Cho, Kelly, O’Donnell, Christopher J, Gaziano, John M, Wilson, Peter, Rotimi, Charles N, Hazelhurst, Scott, Ramsay, Michèle, Trembath, Richard C, van Heel, David A, Tamiya, Gen, Yamamoto, Masayuki, Kim, Bong-Jo, Mohlke, Karen L, Frayling, Timothy M, Hirschhorn, Joel N, Kathiresan, Sekar, Boehnke, Michael, Natarajan, Pradeep, Peloso, Gina M, Brown, Christopher D, Morris, Andrew P, Assimes, Themistocles L, Deloukas, Panos, Sun, Yan V, Willer, Cristen J
Publikováno v:
Nature, vol. 600, no. 7890, pp. 675-679
Graham, S E, Clarke, S L, Wu, K-H H, Kanoni, S, Zajac, G J M, Ramdas, S, Surakka, I, Ntalla, I, Vedantam, S, Winkler, T W, Locke, A E, Marouli, E, Hwang, M Y, Han, S, Narita, A, Choudhury, A, Bentley, A R, Ekoru, K, Verma, A, Trivedi, B, Martin, H C, Hunt, K A, Hui, Q, Klarin, D, Zhu, X, Thorleifsson, G, Helgadottir, A, Gudbjartsson, D F, Holm, H, Olafsson, I, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B M, Rasheed, H, Ruotsalainen, S E, Havulinna, A S, Veturi, Y, Feng, Q, Rosenthal, E A, Lingren, T, Pacheco, J A, Pendergrass, S A, Haessler, J, Giulianini, F, Bradford, Y, Miller, J E, Campbell, A, Lin, K, Millwood, I Y, Hindy, G, Rasheed, A, Faul, J D, Zhao, W, Weir, D R, Turman, C, Huang, H, Graff, M, Mahajan, A, Brown, M R, Zhang, W, Yu, K, Schmidt, E M, Pandit, A, Gustafsson, S, Yin, X, Luan, J, Zhao, J-H, Matsuda, F, Jang, H-M, Yoon, K, Medina-Gomez, C, Pitsillides, A, Hottenga, J J, Willemsen, G, Wood, A R, Ji, Y, Gao, Z, Haworth, S, Mitchell, R E, Chai, J F, Aadahl, M, Yao, J, Manichaikul, A, Warren, H R, Ramirez, J, Bork-Jensen, J, Karhus, L L, Goel, A, Sabater-Lleal, M, Noordam, R, Sidore, C, Fiorillo, E, McDaid, A F, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Møllehave, L T, Thuesen, B H, Munz, M, Zeng, L, Huang, J, Yang, B, Poveda, A, Kurbasic, A, Lamina, C, Forer, L, Scholz, M, Galesloot, T E, Bradfield, J P, Daw, E W, Zmuda, J M, Mitchell, J S, Fuchsberger, C, Christensen, H, Brody, J A, Feitosa, M F, Wojczynski, M K, Preuss, M, Mangino, M, Christofidou, P, Verweij, N, Benjamins, J W, Engmann, J, Kember, R L, Slieker, R C, Lo, K S, Zilhao, N R, Phuong Le, Kleber, M E, Delgado, G E, Huo, S, Ikeda, D D, Iha, H, Yang, J, Liu, J, Leonard, H L, Marten, J, Schmidt, B, Arendt, M, Smyth, L J, Canadas-Garre, M, Wang, C, Nakatochi, M, Wong, A, Hutri-Kahonen, N, Sim, X, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, J C, Lyssenko, V, Ahmed, M, Jackson, A U, Irvin, M R, Oldmeadow, C, Kim, H-N, Ryu, S, Timmers, P R H J, Arbeeva, L, Dorajoo, R, Lange, L A, Chai, X, Prasad, G, Lores-Motta, L, Pauper, M, Long, J, Li, X, Theusch, E, Takeuchi, F, Spracklen, C N, Loukola, A, Bollepalli, S, Warner, S C, Wang, Y X, Wei, W B, Nutile, T, Ruggiero, D, Sung, Y J, Hung, Y-J, Chen, S, Liu, F, Yang, J, Kentistou, K A, Gorski, M, Brumat, M, Meidtner, K, Bielak, L F, Smith, J A, Hebbar, P, Farmaki, A-E, Hofer, E, Lin, M, Xue, C, Zhang, J, Concas, M P, Vaccargiu, S, van der Most, P J, Pitkanen, N, Cade, B E, Lee, J, van Der Laan, S W, Chitrala, K N, Weiss, S, Zimmermann, M E, Lee, J Y, Choi, H S, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, N W, Wang, C A, Lin, S-Y, Wang, J-S, Couture, C, Lyytikainen, L-P, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hildalgo, B, Giannakopoulou, O, Cai, Q, Obura, M O, van Setten, J, Li, X, Schwander, K, Terzikhan, N, Shin, J H, Jackson, R D, Reiner, A P, Martin, L W, Chen, Z, Li, L, Highland, H M, Young, K L, Kawaguchi, T, Thiery, J, Bis, J C, Nadkarni, G N, Launer, L J, Li, H, Nalls, M A, Raitakari, O T, Ichihara, S, Wild, S H, Nelson, C P, Campbell, H, Jager, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, P S, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, Bhatti, F, de Kleijn, D, de Borst, G J, Kim, E K, Adams, H H H, Ikram, M A, Zhu, X, Asselbergs, F W, Kraaijeveld, A O, Beulens, J W J, Shu, X-O, Rallidis, L S, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, A W, Kahonen, M, Perusse, L, Bouchard, C, Tonjes, A, Chen, Y-D I, Pennell, C E, Mori, T A, Lieb, W, Franke, A, Ohlsson, C, Mellstrom, D, Cho, Y S, Lee, H, Yuan, J-M, Koh, W-P, Rhee, S Y, Woo, J-T, Heid, I M, Stark, K J, Volzke, H, Homuth, G, Evans, M K, Zonderman, A B, Polasek, O, Pasterkamp, G, Hoefer, I E, Redline, S, Pahkala, K, Oldehinkel, A J, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Chen, Y E, Bandinelli, S, Dedoussis, G, Thanaraj, T A, Kardia, S L R, Kato, N, Schulze, M B, Girotto, G, Jung, B, Boger, C A, Joshi, P K, Bennett, D A, De Jager, P L, Lu, X, Mamakou, V, Brown, M, Caulfield, M J, Munroe, P B, Guo, X, Ciullo, M, Jonas, J B, Samani, N J, Kaprio, J, Pajukanta, P, Adair, L S, Bechayda, S A, de Silva, H J, Wickremasinghe, A R, Krauss, R M, Wu, J-Y, Zheng, W, den Hollander, A I, Bharadwaj, D, Correa, A, Wilson, J G, Lind, L, Heng, C-K, Nelson, A E, Golightly, Y M, Wilson, J F, Penninx, B, Kim, H-L, Attia, J, Scott, R J, Rao, D C, Arnett, D K, Walker, M, Koistinen, H A, Chandak, G R, Yajnik, C S, Mercader, J M, Tusie-Luna, T, Aguilar-Salinas, C A, Villalpando, C G, Orozco, L, Fornage, M, Tai, E S, van Dam, R M, Lehtimaki, T, Chaturvedi, N, Yokota, M, Liu, J, Reilly, D F, McKnight, A J, Kee, F, Jockel, K-H, McCarthy, M I, Palmer, C N A, Vitart, V, Hayward, C, Simonsick, E, van Duijn, C M, Lu, F, Qu, J, Hishigaki, H, Lin, X, Marz, W, Parra, E J, Cruz, M, Gudnason, V, Tardif, J-C, Lettre, G, 't Hart, L M, Elders, P J M, Damrauer, S M, Kumari, M, Kivimaki, M, van der Harst, P, Spector, T D, Loos, R J F, Province, M A, Psaty, B M, Brandslund, I, Pramstaller, P P, Christensen, K, Ripatti, S, Widen, E, Hakonarson, H, Grant, S F A, Kiemeney, L A L M, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, D, Erdmann, J, Schunkert, H, Franks, P W, Linneberg, A, Jukema, J W, Khera, A V, Mannikko, M, Jarvelin, M-R, Kutalik, Z, Cucca, F, Mook-Kanamori, D O, van Dijk, K W, Watkins, H, Strachan, D P, Grarup, N, Sever, P, Poulter, N, Rotter, J I, Dantoft, T M, Karpe, F, Neville, M J, Timpson, N J, Cheng, C-Y, Wong, T-Y, Khor, C C, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, A T, Pedersen, N L, Magnusson, P K E, Boomsma, D I, de Geus, E J C, Cupples, L A, van Meurs, J B J, Ghanbari, M, Rsen, P G-L, Huang, W, Kim, Y J, Tabara, Y, Wareham, N J, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, J C, Kooner, J S, de Vries, P S, Morrison, A C, North, K E, Daviglus, M, Kraft, P, Martin, N G, Whitfield, J B, Abbas, S, Saleheen, D, Walters, R G, Holmes, M V, Black, C, Smith, B H, Justice, A E, Baras, A, Buring, J E, Ridker, P M, Chasman, D I, Kooperberg, C, Wei, W-Q, Jarvik, G P, Namjou, B, Hayes, M G, Ritchie, M D, Jousilahti, P, Salomaa, V, Hveem, K, Asvold, B O, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Thorsteinsdottir, U, Stefansson, K, Ho, Y-L, Lynch, J A, Rader, D J, Tsao, P S, Chang, K-M, Cho, K, O'Donnell, C J, Gaziano, J M, Wilson, P, Rotimi, C N, Hazelhurst, S, Ramsay, M, Trembath, R C, van Heel, D A, Tamiya, G, Yamamoto, M, Kim, B-J, Mohlke, K L, Frayling, T M, Hirschhorn, J N, Kathiresan, S, Boehnke, M, Natarajan, P, Peloso, G M, Brown, C D, Morris, A P, Assimes, T L, Deloukas, P, Sun, Y V & Willer, C J 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
VA Million Veteran Program & Global Lipids Genetics Consortium* 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Nature, 600(7890), 675-679. Nature Publishing Group
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Nature
Graham, S E, Clarke, S L, Wu, K-H H, Kanoni, S, Zajac, G J M, Ramdas, S, Surakka, I, Ntalla, I, Vedantam, S, Winkler, T W, Locke, A E, Marouli, E, Hwang, M Y, Han, S, Narita, A, Choudhury, A, Bentley, A R, Ekoru, K, Verma, A, Trivedi, B, Martin, H C, Hunt, K A, Hui, Q, Klarin, D, Zhu, X, Thorleifsson, G, Helgadottir, A, Gudbjartsson, D F, Holm, H, Olafsson, I, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B M, Rasheed, H, Ruotsalainen, S E, Havulinna, A S, Veturi, Y, Weir, D R, Brown, M R, Smyth, L J, Cañadas-Garre, M, Li, X, Nelson, C P, McKnight, A J, Kee, F, Wilson, P & Brown, C D 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Graham, S E, Hottenga, J J, Willemsen, G, Boomsma, D I, de Geus, E J C, Willer, C J & VA Million Veteran Program 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Nature, 600, 675-679
Nature, 600, 7890, pp. 675-679
et al. 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, pp. 675–679 (2021) . https://doi.org/10.1038/s41586-021-04064-3
2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Nature, 600(7890), 675-+. NATURE PORTFOLIO
Nature, 600, 675-679. Nature Publishing Group
Graham, S E, Clarke, S L, Wu, K-H H, Kanoni, S, Zajac, G J M, Ramdas, S, Surakka, I, Ntalla, I, Vedantam, S, Winkler, T W, Locke, A E, Marouli, E, Hwang, M Y, Han, S, Narita, A, Choudhury, A, Bentley, A R, Ekoru, K, Verma, A, Trivedi, B, Martin, H C, Hunt, K A, Hui, Q, Klarin, D, Zhu, X, Thorleifsson, G, Helgadottir, A, Gudbjartsson, D F, Holm, H, Olafsson, I, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B M, Rasheed, H, Ruotsalainen, S E, Havulinna, A S, Veturi, Y, Feng, Q, Rosenthal, E A, Lingren, T, Pacheco, J A, Pendergrass, S A, Haessler, J, Giulianini, F, Bradford, Y, Miller, J E, Campbell, A, Lin, K, Millwood, I Y, Hindy, G, Rasheed, A, Faul, J D, Zhao, W, Weir, D R, Turman, C, Huang, H, Graff, M, Mahajan, A, Brown, M R, Zhang, W, Yu, K, Schmidt, E M, Pandit, A, Gustafsson, S, Yin, X, Luan, J, Zhao, J-H, Matsuda, F, Jang, H-M, Yoon, K, Medina-Gomez, C, Pitsillides, A, Hottenga, J J, Willemsen, G, Wood, A R, Ji, Y, Gao, Z, Haworth, S, Mitchell, R E, Chai, J F, 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Dorajoo, R, Lange, L A, Chai, X, Prasad, G, Lores-Motta, L, Pauper, M, Long, J, Li, X, Theusch, E, Takeuchi, F, Spracklen, C N, Loukola, A, Bollepalli, S, Warner, S C, Wang, Y X, Wei, W B, Nutile, T, Ruggiero, D, Sung, Y J, Hung, Y-J, Chen, S, Liu, F, Yang, J, Kentistou, K A, Gorski, M, Brumat, M, Meidtner, K, Bielak, L F, Smith, J A, Hebbar, P, Farmaki, A-E, Hofer, E, Lin, M, Xue, C, Zhang, J, Concas, M P, Vaccargiu, S, van der Most, P J, Pitkanen, N, Cade, B E, Lee, J, van Der Laan, S W, Chitrala, K N, Weiss, S, Zimmermann, M E, Lee, J Y, Choi, H S, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, N W, Wang, C A, Lin, S-Y, Wang, J-S, Couture, C, Lyytikainen, L-P, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hildalgo, B, Giannakopoulou, O, Cai, Q, Obura, M O, van Setten, J, Li, X, Schwander, K, Terzikhan, N, Shin, J H, Jackson, R D, Reiner, A P, Martin, L W, Chen, Z, Li, L, Highland, H M, Young, K L, Kawaguchi, T, Thiery, J, Bis, J C, Nadkarni, G N, Launer, L J, Li, H, Nalls, M A, Raitakari, O T, Ichihara, S, Wild, S H, Nelson, C P, Campbell, H, Jager, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, P S, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, Bhatti, F, de Kleijn, D, de Borst, G J, Kim, E K, Adams, H H H, Ikram, M A, Zhu, X, Asselbergs, F W, Kraaijeveld, A O, Beulens, J W J, Shu, X-O, Rallidis, L S, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, A W, Kahonen, M, Perusse, L, Bouchard, C, Tonjes, A, Chen, Y-D I, Pennell, C E, Mori, T A, Lieb, W, Franke, A, Ohlsson, C, Mellstrom, D, Cho, Y S, Lee, H, Yuan, J-M, Koh, W-P, Rhee, S Y, Woo, J-T, Heid, I M, Stark, K J, Volzke, H, Homuth, G, Evans, M K, Zonderman, A B, Polasek, O, Pasterkamp, G, Hoefer, I E, Redline, S, Pahkala, K, Oldehinkel, A J, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Chen, Y E, Bandinelli, S, Dedoussis, G, Thanaraj, T A, Kardia, S L R, Kato, N, Schulze, M B, Girotto, G, Jung, B, Boger, C A, Joshi, P K, Bennett, D A, De Jager, P L, Lu, X, Mamakou, V, Brown, M, Caulfield, M J, Munroe, P B, Guo, X, Ciullo, M, Jonas, J B, Samani, N J, Kaprio, J, Pajukanta, P, Adair, L S, Bechayda, S A, de Silva, H J, Wickremasinghe, A R, Krauss, R M, Wu, J-Y, Zheng, W, den Hollander, A I, Bharadwaj, D, Correa, A, Wilson, J G, Lind, L, Heng, C-K, Nelson, A E, Golightly, Y M, Wilson, J F, Penninx, B, Kim, H-L, Attia, J, Scott, R J, Rao, D C, Arnett, D K, Walker, M, Koistinen, H A, Chandak, G R, Yajnik, C S, Mercader, J M, Tusie-Luna, T, Aguilar-Salinas, C A, Villalpando, C G, Orozco, L, Fornage, M, Tai, E S, van Dam, R M, Lehtimaki, T, Chaturvedi, N, Yokota, M, Liu, J, Reilly, D F, McKnight, A J, Kee, F, Jockel, K-H, McCarthy, M I, Palmer, C N A, Vitart, V, Hayward, C, Simonsick, E, van Duijn, C M, Lu, F, Qu, J, Hishigaki, H, Lin, X, Marz, W, Parra, E J, Cruz, M, Gudnason, V, Tardif, J-C, Lettre, G, 't Hart, L M, Elders, P J M, Damrauer, S M, Kumari, M, Kivimaki, M, van der Harst, P, Spector, T D, Loos, R J F, Province, M A, Psaty, B M, Brandslund, I, Pramstaller, P P, Christensen, K, Ripatti, S, Widen, E, Hakonarson, H, Grant, S F A, Kiemeney, L A L M, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, D, Erdmann, J, Schunkert, H, Franks, P W, Linneberg, A, Jukema, J W, Khera, A V, Mannikko, M, Jarvelin, M-R, Kutalik, Z, Cucca, F, Mook-Kanamori, D O, van Dijk, K W, Watkins, H, Strachan, D P, Grarup, N, Sever, P, Poulter, N, Rotter, J I, Dantoft, T M, Karpe, F, Neville, M J, Timpson, N J, Cheng, C-Y, Wong, T-Y, Khor, C C, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, A T, Pedersen, N L, Magnusson, P K E, Boomsma, D I, de Geus, E J C, Cupples, L A, van Meurs, J B J, Ghanbari, M, Rsen, P G-L, Huang, W, Kim, Y J, Tabara, Y, Wareham, N J, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, J C, Kooner, J S, de Vries, P S, Morrison, A C, North, K E, Daviglus, M, Kraft, P, Martin, N G, Whitfield, J B, Abbas, S, Saleheen, D, Walters, R G, Holmes, M V, Black, C, Smith, B H, Justice, A E, Baras, A, Buring, J E, Ridker, P M, Chasman, D I, Kooperberg, C, Wei, W-Q, Jarvik, G P, Namjou, B, Hayes, M G, Ritchie, M D, Jousilahti, P, Salomaa, V, Hveem, K, Asvold, B O, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Thorsteinsdottir, U, Stefansson, K, Ho, Y-L, Lynch, J A, Rader, D J, Tsao, P S, Chang, K-M, Cho, K, O'Donnell, C J, Gaziano, J M, Wilson, P, Rotimi, C N, Hazelhurst, S, Ramsay, M, Trembath, R C, van Heel, D A, Tamiya, G, Yamamoto, M, Kim, B-J, Mohlke, K L, Frayling, T M, Hirschhorn, J N, Kathiresan, S, Boehnke, M, Natarajan, P, Peloso, G M, Brown, C D, Morris, A P, Assimes, T L, Deloukas, P, Sun, Y V & Willer, C J 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
VA Million Veteran Program & Global Lipids Genetics Consortium* 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Nature, 600(7890), 675-679. Nature Publishing Group
NATURE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Nature
Graham, S E, Clarke, S L, Wu, K-H H, Kanoni, S, Zajac, G J M, Ramdas, S, Surakka, I, Ntalla, I, Vedantam, S, Winkler, T W, Locke, A E, Marouli, E, Hwang, M Y, Han, S, Narita, A, Choudhury, A, Bentley, A R, Ekoru, K, Verma, A, Trivedi, B, Martin, H C, Hunt, K A, Hui, Q, Klarin, D, Zhu, X, Thorleifsson, G, Helgadottir, A, Gudbjartsson, D F, Holm, H, Olafsson, I, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B M, Rasheed, H, Ruotsalainen, S E, Havulinna, A S, Veturi, Y, Weir, D R, Brown, M R, Smyth, L J, Cañadas-Garre, M, Li, X, Nelson, C P, McKnight, A J, Kee, F, Wilson, P & Brown, C D 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Graham, S E, Hottenga, J J, Willemsen, G, Boomsma, D I, de Geus, E J C, Willer, C J & VA Million Veteran Program 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Nature, 600, 675-679
Nature, 600, 7890, pp. 675-679
et al. 2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, pp. 675–679 (2021) . https://doi.org/10.1038/s41586-021-04064-3
2021, ' The power of genetic diversity in genome-wide association studies of lipids ', Nature, vol. 600, no. 7890, pp. 675-679 . https://doi.org/10.1038/s41586-021-04064-3
Nature, 600(7890), 675-+. NATURE PORTFOLIO
Nature, 600, 675-679. Nature Publishing Group
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use 1 . Despite advances in prevention and treatment, in particular through reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c5820ad43b8d524061390bc57aa6f
https://doi.org/10.1038/s41586-021-04064-3
https://doi.org/10.1038/s41586-021-04064-3
Autor:
Liu A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; These authors contributed equally: Aoxing Liu, Giulio Genovese, Yajie Zhao., Genovese G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; These authors contributed equally: Aoxing Liu, Giulio Genovese, Yajie Zhao., Zhao Y; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; These authors contributed equally: Aoxing Liu, Giulio Genovese, Yajie Zhao., Pirinen M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Publich Health, University of Helsinki, Helsinki, Finland.; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland., Zekavat MM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Kentistou K; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Yang Z; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Yu K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Vlasschaert C; Department of Medicine, Queen's University, Kingston, ON, Canada., Liu X; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Brown DW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA., Hudjashov G; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Gorman B; Center for Data and Computational Sciences (C-DACS), VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.; Booz Allen Hamilton, McLean, VA, USA., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Zhou W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Pyarajan S; Center for Data and Computational Sciences (C-DACS), VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tuzov V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Pajuste FD; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Aavikko M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Sipilä TP; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Ghazal A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Freedman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Song L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Gardner EJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Sankaran VG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ollila HM; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center of Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Tukiainen T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Natarajan P; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center of Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Daly MJ; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Bick A; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., McCarroll SA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Loh PR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; These authors jointly supervised this work: Po-Ru Loh, Andrea Ganna, John R.B. Perry, Mitchell J. Machiela., Ganna A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; These authors jointly supervised this work: Po-Ru Loh, Andrea Ganna, John R.B. Perry, Mitchell J. Machiela., Perry JRB; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; These authors jointly supervised this work: Po-Ru Loh, Andrea Ganna, John R.B. Perry, Mitchell J. Machiela., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; These authors jointly supervised this work: Po-Ru Loh, Andrea Ganna, John R.B. Perry, Mitchell J. Machiela.
Publikováno v:
MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jan 31. Date of Electronic Publication: 2023 Jan 31.