Targeting for cardioplegia: arresting agents and their safety

Autor: Fallouh, Hazem B, Kentish, Jonathan C, Chambers, David J

Publikováno v: In Current Opinion in Pharmacology April 2009 9(2):220-226

Monophosphorylation of cardiac troponin-I at Ser23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis

Autor: Martin-garrido, Abel, Biesiadecki, Brandon J., Salhi, Hussam E., Shaifta, Yasin, Dos Remedios, Cristobal G., Ayaz-guner, Serife, Cai, Wenxuan, Ge, Ying, Avkiran, Metin, Kentish, Jonathan C.

Publikováno v: Martin-garrido, A, Biesiadecki, B J, Salhi, H E, Shaifta, Y, Dos Remedios, C G, Ayaz-guner, S, Cai, W, Ge, Y, Avkiran, M & Kentish, J C 2018, ' Monophosphorylation of cardiac troponin-I at Ser23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis ', Journal of Biological Chemistry, vol. 293, no. 22, pp. 8588-8599 . https://doi.org/10.1074/jbc.RA117.001292

The acceleration of myocardial relaxation produced by β-adrenoreceptor stimulation is mediated in part by protein kinase A (PKA)-mediated phosphorylation of cardiac troponin-I (cTnI), which decreases myofibrillar Ca2+ sensitivity. Previous evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::62554011053051d3c8eb83c1bf95e91a
https://kclpure.kcl.ac.uk/en/publications/169d101f-e609-4d48-accf-a15cb0ee68c9

Reduced First-Phase Ejection Fraction and Sustained Myocardial Wall Stress in Hypertensive Patients With Diastolic Dysfunction: A Manifestation of Impaired Shortening Deactivation That Links Systolic to Diastolic Dysfunction and Preserves Systolic Ejection Fraction

Autor: Gu, Haotian, Li, Ye, Fok, Henry, Simpson, John, Kentish, Jonathan C., Shah, Ajay M., Chowienczyk, Philip J.

Publikováno v: Hypertension (Dallas, Tex. : 1979)

Supplemental Digital Content is available in the text.
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense of diastolic dysfunction. We examined the relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4dd07302e48eb9ae354ba975db00440e
https://pubmed.ncbi.nlm.nih.gov/28223470

Reduced First-Phase Ejection Fraction and Sustained Myocardial Wall Stress in Hypertensive Patients With Diastolic Dysfunction: A Manifestation of Impaired Shortening Deactivation That Links Systolic to Diastolic Dysfunction and Preserves Systolic...

Autor: Haotian Gu, Ye Li, Fok, Henry, Simpson, John, Kentish, Jonathan C., Shah, Ajay M., Chowienczyk, Philip J., Gu, Haotian, Li, Ye

Publikováno v: Hypertension (0194911X); Apr2017, Vol. 69 Issue 4, p633-640, 8p

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