Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kenth Hallberg"'
Autor:
Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhib
Externí odkaz:
https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c524
Autor:
Tomas Akerud, Hannah de la Motte, Eva Hurt-Camejo, Tim D. J. Perkins, Åsa Månsson, Frank Jansen, Hans-Georg Beisel, Mikael Dahlström, Gabrielle Saarinen, Fabrizio Giordanetto, Robert G. Roth, Marie Ahlqvist, Fredrik Klingegård, Birgitta Rosengren, Laurent Knerr, Kenth Hallberg, Ingemar Starke, Jenny Sandmark, Daniel Pettersen, Nidhal Selmi, Margareta Herslöf, Johan Brengdahl, Tommy Olsson, Mattias Rohman, Peter Nordberg, Johan Broddefalk
Publikováno v:
ACS Medicinal Chemistry Letters. 9:594-599
[Image: see text] In order to assess the potential of sPLA(2)-X as a therapeutic target for atherosclerosis, novel sPLA(2) inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3062a7d8619a16b010f0164ff18f98cf
https://doi.org/10.1021/acsmedchemlett.7b00505
https://doi.org/10.1021/acsmedchemlett.7b00505
Autor:
Jessica Hollers, Martin Norin, Katarina Färnegårdh, Jemina Lehto, Nadilly Bonagas, N. Markova, Carina Norström, Anna Huguet Ninou, Petra Groth, Nina M. S. Gustafsson, Martin Andersson, Jessica Martinsson, Baek Kim, Elisee Wiita, Rosa Pennisi, Thomas Olin, Kenth Hallberg, Johan Schultz, Mattias Jönsson, Petra Marttila, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ea467c334b76d93f503c7eee3f7fb8
Autor:
Lionel Trésaugues, Kilian Huber, Ioanna Panagakou, Camilla Silvander, F. Rahm, Martin Andersson, Antoine Talagas, Oleg Fedorov, Marcus Bauser, Tobias Ginman, L. Diaz-Saez, Ellermann Manuel, Kenth Hallberg, Rickard Forsblom, Johan Lindström, Mátyás Gorjánácz, Anja Giese, Judith Günther, Lars Boukharta Persson, P. Siejka, Jenny Viklund, Ulrika Ericsson
Publikováno v:
Journal of Medicinal Chemistry. 61(6)
Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-707 was just published as a target validation small molecule probe for assessing the effects of pharmacological inhibition of MTH1 on tumor cell survival, both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df850d12469fccbc99cfeb9d1e544696
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Emre M. Isin, David Blomberg Saitton, Eric Wellner, Rutger H. A. Folmer, Pernilla Ståhlberg, Kay Brickmann, Volker Schnecke, Öjvind Davidsson, Christoffer Bengtsson, Lars-Olof Larsson, Stefan Hallén, Pernilla Sörme, Hong Wan, Kenth Hallberg, Linda Öster, Ragnar Hovland, Lars Löfgren, Alleyn T. Plowright, Bengt Kull, Tobias Noeske, Stefan Blaho, Petra Johannesson, Tomas Drmota, Kristina Nilsson, Johan Broddefalk, Nick Oakes
Publikováno v:
Bioorganicmedicinal chemistry. 19(10)
Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab801bb919b253dd5e5e3a7b103724d
https://pubmed.ncbi.nlm.nih.gov/21515056
https://pubmed.ncbi.nlm.nih.gov/21515056
Publikováno v:
Advances in Photosynthesis and Respiration ISBN: 9781402040603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ad48bb4e1fee37680acbd5e98f694b0
https://doi.org/10.1007/978-1-4020-4061-0_11
https://doi.org/10.1007/978-1-4020-4061-0_11
Autor:
Håkan Mellstedt, Elisee Wiita, Carina Norström, Jessica Martinsson, Lars Ährlund-Richter, Mattias Jonsson, Kenth Hallberg, Rune Ringom, Katarina Färnegårdh
Publikováno v:
Journal of Clinical Oncology. 30:e13518-e13518
e13518 Background: By producing fructose-2,6-bisphosphate, PFKFB3 functions as an activator of anaerobic glycolysis. PFKFB3 is both over expressed and over activated in many of the types of human cancer. Specific inhibition of the PFKFB3 enzyme resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a43b5f88140107217f2c509c7f77d679
https://doi.org/10.1200/jco.2012.30.15_suppl.e13518
https://doi.org/10.1200/jco.2012.30.15_suppl.e13518