Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kentaro TOKUDOME"'
Autor:
Masato Kinboshi, Saki Shimizu, Kentaro Tokudome, Tomoji Mashimo, Tadao Serikawa, Hidefumi Ito, Ryosuke Takahashi, Akio Ikeda, Yukihiro Ohno
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17984- (2023)
Leucine-rich glioma-inactivated 1 (LGI1) was identified as a causative gene of autosomal dominant lateral temporal lobe epilepsy. We previously reported that Lgi1-mutant rats carrying a missense mutation (L385R) showed audiogenic seizure-susceptibili
Externí odkaz:
https://doaj.org/article/de5904eb65e64d36bca2587891fe0b37
Autor:
Yoneko Hayase, Shigeru Amano, Koichi Hashizume, Takashi Tominaga, Hiroyuki Miyamoto, Yukie Kanno, Yukiko Ueno-Inoue, Takayoshi Inoue, Mayumi Yamada, Shigehiro Ogata, Shabeesh Balan, Ken Hayashi, Yoshiki Miura, Kentaro Tokudome, Yukihiro Ohno, Takuma Nishijo, Toshihiko Momiyama, Yuchio Yanagawa, Akiko Takizawa, Tomoji Mashimo, Tadao Serikawa, Akihiro Sekine, Eiji Nakagawa, Eri Takeshita, Takeo Yoshikawa, Chikako Waga, Ken Inoue, Yu-ichi Goto, Yoichi Nabeshima, Nobuo Ihara, Kazuhiro Yamakawa, Shinichiro Taya, Mikio Hoshino
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the resp
Externí odkaz:
https://doaj.org/article/83b2c846e60840adb9d55f24ef0bdf26
Autor:
Shunji Nishide, Junji Uchida, Shinji Matsunaga, Kentaro Tokudome, Takehiro Yamaguchi, Kazuya Kabei, Taiki Moriya, Katsuyuki Miura, Tatsuya Nakatani, Shuhei Tomita
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 2, Pp 122-126 (2020)
Tumor blood vessels have leaky and low blood flow properties, which lead to hypoxia and low nutrient levels in the tumor tissue area known as the tumor microenvironment (TME). We reported that the prolyl-hydroxylase (PHD) inhibitor Roxadustat normali
Externí odkaz:
https://doaj.org/article/710a0948a85942fbbe28c400d0dc2919
Autor:
Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda, Atsushi Inanobe, Yoshihisa Kurachi, Seiji Inoue, Yukihiro Ohno
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Inwardly rectifying potassium (Kir) 4.1 channels in astrocytes regulate neuronal excitability by mediating spatial potassium buffering. Although dysfunction of astrocytic Kir4.1 channels is implicated in the development of epileptic seizures, the fun
Externí odkaz:
https://doaj.org/article/26b74b2d78b2456f84e62102d0768ce6
Autor:
Kentaro Tokudome, Takahiro Okumura, Ryo Terada, Saki Shimizu, Naofumi Kunisawa, Tomoji Mashimo, Tadao Serikawa, Masashi Sasa, Yukihiro Ohno
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we rece
Externí odkaz:
https://doaj.org/article/3d395547ec23421592ae0df6bf2ec3cc
Autor:
Yusaku WATANABE, Shingo SHIOYA, Tetsuhito ARIKIZONO, Syuzou TASHIMA, Toshiyuki CHOSA, Hiroshi SUGITA, Kyouko MIZUKAMI, Kentaro TOKUDOME, Kaoru HIJIKURO, Kouichirou SHIGETA
Publikováno v:
Choonpa Igaku. 50:121-125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69fc9c41e67a68dcd785ceb522b72138
https://doi.org/10.3179/jjmu.jjmu.a.234
https://doi.org/10.3179/jjmu.jjmu.a.234
Autor:
Noriaki Samukawa, Takehiro Yamaguchi, Yuriko Ozeki, Sohkichi Matsumoto, Masayuki Igarashi, Naoko Kinoshita, Masaki Hatano, Kentaro Tokudome, Shinji Matsunaga, Shuhei Tomita
Publikováno v:
Microbiology. 168
Tuberculosis (TB) is treated by chemotherapy with multiple anti-TB drugs for a long period, spanning 6 months even in a standard course. In perspective, to prevent the emergence of antimicrobial resistance, novel drugs that act synergistically or add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caad65ac115d94960db82baa2e3a96a3
https://doi.org/10.1099/mic.0.001285
https://doi.org/10.1099/mic.0.001285
Autor:
Akihiro Sekine, Mikio Hoshino, Tomoji Mashimo, Ken Hayashi, Shigeru Amano, Mayumi Yamada, Takuma Nishijo, Hiroyuki Miyamoto, Toshihiko Momiyama, Nobuo Ihara, Ken Inoue, Chikako Waga, Shigehiro Ogata, Eri Takeshita, Koichi Hashizume, Yukie Kanno, Yuchio Yanagawa, Takeo Yoshikawa, Tadao Serikawa, Yukihiro Ohno, Yukiko Ueno-Inoue, Eiji Nakagawa, Yo-ichi Nabeshima, Shinichiro Taya, Akiko Takizawa, Shabeesh Balan, Yu-ichi Goto, Takashi Tominaga, Yoneko Hayase, Kazuhiro Yamakawa, Kentaro Tokudome, Takayoshi Inoue, Yoshiki Miura
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the responsible g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d905cbde994b58ca5ed5c62b8ad722
https://doi.org/10.1186/s40478-020-01082-6
https://doi.org/10.1186/s40478-020-01082-6
Autor:
Kentaro Tokudome, Masaaki Ueki, Atsuki Nakamura, Takehiro Yamaguchi, Shinji Matsunaga, Shuhei Tomita
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2bfa290205beabf502e850ddff5128
https://doi.org/10.1254/jpssuppl.95.0_1-p-012
https://doi.org/10.1254/jpssuppl.95.0_1-p-012
Autor:
Shinji Matsunaga, Kazuyuki Yamaguchi, Ryo Hirakawa, Kentaro Tokudome, Takehiro Yamaguchi, Shuhei Tomita
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:2-O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a202f63c9aee2f4ec014a019406190d
https://doi.org/10.1254/jpssuppl.95.0_2-o-054
https://doi.org/10.1254/jpssuppl.95.0_2-o-054