Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kentaro Otake"'
Autor:
Kentaro Otake, Keiko Adachi‐Tominari, Hiroaki Nagai, Masayo Saito, Osamu Sano, Yoshihiko Hirozane, Hidehisa Iwata
Publikováno v:
FEBS Open Bio, Vol 11, Iss 2, Pp 494-506 (2021)
Extracellular vesicles (EVs) contain various cargo molecules, including RNAs and proteins. EVs, which include exosomes, are predicted to be suitable surrogates of their source cells for liquid biopsy to measure biomarkers. Several studies have perfor
Externí odkaz:
https://doaj.org/article/dcc6ecb3b59d4bcb8c572e2591808810
Autor:
Sebastian Sjoqvist, Kentaro Otake
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5237 (2023)
Saliva is gaining increasing attention as a source of biomarkers due to non-invasive and undemanding collection access. Extracellular vesicles (EVs) are nano-sized, cell-released particles that contain molecular information about their parent cells.
Externí odkaz:
https://doaj.org/article/99f8b1bcf0e64c68a284523bb7ff3abd
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Background Exosomes are a subset of extracellular vesicles 30–200 nm in diameter secreted from cells, which contain functional mRNAs and microRNAs. Cerebrospinal fluid (CSF) is the primary source for liquid biopsy to examine diseases in ce
Externí odkaz:
https://doaj.org/article/04b48fd409644a808f8e41bdd4d52860
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9425 (2020)
There is a lack of reliable biomarkers for disorders of the central nervous system (CNS), and diagnostics still heavily rely on symptoms that are both subjective and difficult to quantify. The cerebrospinal fluid (CSF) is a promising source of biomar
Externí odkaz:
https://doaj.org/article/14f858ff1295435d8b8dadb0da430ddb
Autor:
Sebastian Sjöqvist, Kentaro Otake
Publikováno v:
Biochemical and Biophysical Research Communications. 613:166-173
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder which is characterized by progressive degeneration of the motor system. Typically, the disease starts with focal weakness which spreads to involve most muscles and leads to dea
Autor:
Hiroaki Nagai, Yoshihiko Hirozane, Kentaro Otake, Osamu Sano, Hidehisa Iwata, Masayo Saito, Keiko Adachi-Tominari
Publikováno v:
FEBS Open Bio, Vol 11, Iss 2, Pp 494-506 (2021)
FEBS Open Bio
FEBS Open Bio
Extracellular vesicles (EVs) are secreted from various cell types and carry cargo derived from their source cells. However, the quantitative relationship between the cargos of EVs and that of their source cells is unclear, especially for mRNA. To elu
Autor:
Fumito Takada, Takahito Kasahara, Kentaro Otake, Takamitsu Maru, Masanori Miwa, Kei Muto, Minoru Sasaki, Yoshihiko Hirozane, Masato Yoshikawa, Junichiro Yamaguchi
Publikováno v:
ACS medicinal chemistry letters. 13(9)
We report the discovery of two compounds, TKD150 and TKD152, that promote the aggregation of α-synuclein (aSN) using a real-time quaking-induced conversion (RT-QuIC) assay to detect abnormal aSN. By utilizing a Pd-catalyzed C-H arylation of benzoxaz
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 217:114852
Mutations in the GBA gene, encoding glucocerebrosidase (GCase), are linked to Gaucher disease (GD) and are the most common risk factors for Parkinson's disease (PD). The glucosylsphingosine (GlcSph) in cerebrospinal fluid (CSF) is used as a pharmacod
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9425, p 9425 (2020)
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9425, p 9425 (2020)
There is a lack of reliable biomarkers for disorders of the central nervous system (CNS), and diagnostics still heavily rely on symptoms that are both subjective and difficult to quantify. The cerebrospinal fluid (CSF) is a promising source of biomar
Autor:
Hiroshi Uejima, Yoshiki Katou, Yuji Kawamata, Shumpei Murata, Kuniko Kikuchi, Satoru Matsumoto, Kentaro Otake, Mika Teratani, Yasutaka Hoashi, Kenjo Eriya, Masahiro Nogami, Yukimasa Makita
Publikováno v:
Biochemical and Biophysical Research Communications. 493:800-806
Hepatocellular carcinoma (HCC) is still one of the major causes of cancer-related death. Kinetochore-associated protein 2 (KNTC2) is specifically upregulated in tumor tissues of HCC patients and recognized as a potential candidate target for the trea