Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Kentaro Oh-Hashi"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5787 (2023)
OSW-1, a steroidal saponin isolated from the bulbs of Ornithogalum saundersiae, is a promising compound for an anticancer drug; however, its cytotoxic mechanisms have not been fully elucidated. Therefore, we analyzed the stress responses triggered by
Externí odkaz:
https://doaj.org/article/de140c0d219e475d85c861196d17c998
Autor:
Mahmoud Kandeel, Byoung Kwon Park, Mohamed A. Morsy, Katharigatta N. Venugopala, Kentaro Oh-hashi, Mohammed Al-Nazawi, Hyung-Joo Kwon
Publikováno v:
Dr. Sulaiman Al Habib Medical Journal, Vol 3, Iss 4 (2021)
Infection by the emerging, potentially zoonotic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) presents a severe health hazard to humans and is often fatal. Given the lack of particular medicines against MERS-CoV, drug discovery studies are
Externí odkaz:
https://doaj.org/article/80dd0318c1e14ac19bb3f7f330e58d2a
Autor:
Mahmoud Kandeel, Mizuki Yamamoto, Byoung Kwon Park, Abdulla Al-Taher, Aya Watanabe, Jin Gohda, Yasushi Kawaguchi, Kentaro Oh-hashi, Hyung-Joo Kwon, Jun-ichiro Inoue
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through co
Externí odkaz:
https://doaj.org/article/d8fad0c9c86e46dab57d04c7b02b163e
Publikováno v:
Dr. Sulaiman Al Habib Medical Journal, Vol 3, Iss 2 (2021)
Cytokine storm is the major cause of death in patients with acute respiratory distress caused by COVID-19. Because cytokine storm is a life-threatening condition, it is important to treat patients with the most appropriate drugs depending on their in
Externí odkaz:
https://doaj.org/article/47c67cffbf49440aa554047f1f915828
Autor:
Yuki Nomura, Charity F. Sylvester, Lisa O. Nguyen, Mahmoud Kandeel, Yoko Hirata, Imran N. Mungrue, Kentaro Oh-hashi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100834- (2020)
The Unfolded Protein Response pathway is a conserved signaling mechanism having important roles in cellular physiology and is perturbed accompanying disease. We previously identified the novel UPR target gene CHAC1, a direct target of ATF4, downstrea
Externí odkaz:
https://doaj.org/article/4be36bd513c741c883fe194202dd983d
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 282 (2022)
The goal of achieving anti-inflammatory efficacy with the fewest possible adverse effects through selective COX-2 inhibition is still being investigated in order to develop drugs with safe profiles. This work shows the efficacy and safety profile of
Externí odkaz:
https://doaj.org/article/b27c7d591ed342ce9c07d531776c8a5b
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 40-45 (2017)
A split NanoLuc assay system consisting of two fragments, large N-terminal and small C-terminal regions (NanoBiT), was developed to investigate protein-protein interactions within living cells. Interestingly, the replacement of five amino acids among
Externí odkaz:
https://doaj.org/article/898ab9f4f524410588af0859a8a8b376
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2767 (2021)
We performed a comparative analysis of two ER-resident CREB3 family proteins, CREB3 and CREB3L2, in HEK293 cells using pharmacological and genome editing approaches and identified several differences between the two. Treatment with brefeldin A (BFA)
Externí odkaz:
https://doaj.org/article/f8e2f3b16fca4677b95a0f603c01534a
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 92 (2020)
Sulfation is a common modification of extracellular glycans, tyrosine residues on proteins, and steroid hormones, and is important in a wide variety of signaling pathways. We investigated the role of sulfation on endogenous oxidative stress, such as
Externí odkaz:
https://doaj.org/article/e3efc23ce100464a88a1b7fcf63ab028
Autor:
Takeaki Shinjo, Tatsuhide Tanaka, Hiroaki Okuda, Akira T Kawaguchi, Kentaro Oh-Hashi, Yuki Terada, Ayami Isonishi, Shoko Morita-Takemura, Kouko Tatsumi, Masahiko Kawaguchi, Akio Wanaka
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196191 (2018)
Oxidative stress contributes to myocardial ischemia-reperfusion injury, which causes cardiomyocyte death and precipitate life-threatening heart failure. Propofol has been proposed to protect cells or tissues against oxidative stress. However, the mec
Externí odkaz:
https://doaj.org/article/18d986fe79724274b85f706d839ef0ec