Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kentaro, Uemura"'
Autor:
Rahmi Dianty, Junki Hirano, Itsuki Anzai, Yuta Kanai, Tsuyoshi Hayashi, Masae Morimoto, Chikako Kataoka-Nakamura, Sakura Kobayashi, Kentaro Uemura, Chikako Ono, Tokiko Watanabe, Takeshi Kobayashi, Kosuke Murakami, Kenji Kikuchi, Kunimoto Hotta, Toshikazu Yoshikawa, Shuhei Taguwa, Yoshiharu Matsuura
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
It is essential to employ efficient measures to prevent the transmission of pathogenic agents during a pandemic. One such method involves using hypochlorous acid (HClO) solution. The oxidative properties of HClO water (HAW) can contribute to its abil
Externí odkaz:
https://doaj.org/article/0cf9493c3532489f82f95b279d41d5ec
Autor:
Hayato Harima, Yasuko Orba, Shiho Torii, Yongjin Qiu, Masahiro Kajihara, Yoshiki Eto, Naoya Matsuta, Bernard M. Hang’ombe, Yuki Eshita, Kentaro Uemura, Keita Matsuno, Michihito Sasaki, Kentaro Yoshii, Ryo Nakao, William W. Hall, Ayato Takada, Takashi Abe, Michael T. Wolfinger, Martin Simuunza, Hirofumi Sawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals. Despite their importance to public health, there is l
Externí odkaz:
https://doaj.org/article/410a4d1da5904ca1a4c907d93e0828c5
Autor:
Kentaro Uemura, Michihito Sasaki, Takao Sanaki, Shinsuke Toba, Yoshimasa Takahashi, Yasuko Orba, William W. Hall, Katsumi Maenaka, Hirofumi Sawa, Akihiko Sato
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Although the spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a worldwide pandemic, there are currently no virus-specific drugs that are fully effective against SARS-CoV-2. Only a limited number of human
Externí odkaz:
https://doaj.org/article/2b7cd11ffa764b428313e3718883b4d1
Autor:
Kentaro Uemura, Haruaki Nobori, Akihiko Sato, Takao Sanaki, Shinsuke Toba, Michihito Sasaki, Akiho Murai, Noriko Saito-Tarashima, Noriaki Minakawa, Yasuko Orba, Hiroaki Kariwa, William W. Hall, Hirofumi Sawa, Akira Matsuda, Katsumi Maenaka
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103120- (2021)
Summary: Newly emerging or re-emerging viral infections continue to cause significant morbidity and mortality every year worldwide, resulting in serious effects on both health and the global economy. Despite significant drug discovery research agains
Externí odkaz:
https://doaj.org/article/88a87cb6ba924ad085f68b46be907e5f
Autor:
Michihito Sasaki, Shinsuke Toba, Yukari Itakura, Herman M. Chambaro, Mai Kishimoto, Koshiro Tabata, Kittiya Intaruck, Kentaro Uemura, Takao Sanaki, Akihiko Sato, William W. Hall, Yasuko Orba, Hirofumi Sawa
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) possesses a discriminative polybasic cleavage motif in its spike protein that is recognized by the host furin protease. Proteolytic cleavage activates the spike protein, thereby af
Externí odkaz:
https://doaj.org/article/c64901ae7eca4c998ed00de51843f0a0
Autor:
Michihito Sasaki, Kentaro Uemura, Akihiko Sato, Shinsuke Toba, Takao Sanaki, Katsumi Maenaka, William W Hall, Yasuko Orba, Hirofumi Sawa
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009233 (2021)
The spike (S) protein of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) binds to a host cell receptor which facilitates viral entry. A polybasic motif detected at the cleavage site of the S protein has been shown to broaden the cell tro
Externí odkaz:
https://doaj.org/article/b7bd77499f82416eafdca56d36fb014d
Autor:
Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masato Ikawa, Masashi Mizokami, Yoshihiko Maehara, Yoshiharu Matsuura
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Complete removal of hepatitis B virus (HBV) DNA from nuclei is difficult by the current therapies. Recent reports have shown that a novel genome-editing tool using Cas9 with a single-guide RNA (sgRNA) system can cleave the HBV genome in vitr
Externí odkaz:
https://doaj.org/article/6a0a9b8099f94b9897ea32cd37e0cdaf
Autor:
Eiichi Kojima, Atsuhiro Iimuro, Mado Nakajima, Hirotaka Kinuta, Naoya Asada, Yusuke Sako, Zenzaburo Nakata, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Chiaki Wakasa-Morimoto, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6157-6170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47f9735709be42f4cf956b8442fd112d
https://doi.org/10.1021/acs.jmedchem.1c02217
https://doi.org/10.1021/acs.jmedchem.1c02217
Autor:
Mai Kishimoto, Kentaro Uemura, Takao Sanaki, Akihiko Sato, William W. Hall, Hiroaki Kariwa, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
Publikováno v:
Viruses, Vol 13, Iss 3, p 384 (2021)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes host proteases, including a plasma membrane-associated transmembrane protease, serine 2 (TMPRSS2) to cleave and activate the virus spike protein to facilitate cellular entry. Altho
Externí odkaz:
https://doaj.org/article/cbb51e316a2847ca9ba82cf9163d6d49
Autor:
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu, Shiho Yamamoto, Yuki Maruyama, Yoshiyuki Taoda, Koji Kasamatsu, Takahiro Suto, Kensuke Kouki, Atsufumi Nakahashi, Sho Kawashima, Takao Sanaki, Shinsuke Toba, Kentaro Uemura, Tohru Mizutare, Shigeru Ando, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Takafumi Sato, Teruhisa Kato, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6499-6512
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda3f19d8c44fa9a7e86dcee58fa2330
https://doi.org/10.1021/acs.jmedchem.2c00117
https://doi.org/10.1021/acs.jmedchem.2c00117