Výsledky vyhledávání - "Kentaro, Maemura"

Akademický článek

Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

Autor: Wataru Osumi, Denan Jin, Yoshiro Imai, Keitaro Tashiro, Zhong-Lian Li, Yoshinori Otsuki, Kentaro Maemura, Koji Komeda, Fumitoshi Hirokawa, Michihiro Hayashi, Shinji Takai, Kazuhisa Uchiyama

Publikováno v: Journal of Pharmacological Sciences, Vol 129, Iss 4, Pp 233-239 (2015)

The effect of recombinant human soluble thrombomodulin (TM-α) on acute liver failure (ALF) is unclear, and we elucidated the effect of TM-α in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced ALF in mice. Placebo (saline) or TM-α (100 mg/kg

Externí odkaz: https://doaj.org/article/95221bd74874413db33c55db069a4b13

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Prolonged severe hemorrhagic shock at a mean arterial pressure of 40 mmHg does not lead to brain damage in rats

Autor: Akira Takasu, Kentaro Maemura, Toshiaki Minami, Ryosuke Mihara

Publikováno v: Acute Medicine & Surgery

Aim To examine whether prolonged hemorrhagic shock (HS) at a mean arterial pressure (MAP) of 40 mmHg leads to brain damage. Methods Rats were anesthetized with sevoflurane. The HS model consisted of the following phases: I, pressure‐controlled HS a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ae90b4549eb99422e82fb321771d66
https://doi.org/10.1002/ams2.361

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Pathological and molecular analyses of atherosclerotic lesions in ApoE-knockout mice

Autor: Eiko Shibata, Mariko Harada-Shiba, Yoichi Kondo, Kentaro Maemura, Masa-Aki Shibata

Publikováno v: Medical Molecular Morphology. 50:130-144

The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e84dede3e944e58c6832214cae4210
https://doi.org/10.1007/s00795-017-0154-y

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Indomethacin can induce cell death in rat gastric parietal cells through alteration of some apoptosis- and autophagy-associated molecules

Autor: Usama M. Abdelaal, Hoda M. Elsayed, Masa-Aki Shibata, Sahar M. Gebril, Mahmoud R. Hussein, Kazuhide Higuchi, Eman E. Abu-Dief, Yuko Ito, Kentaro Maemura, Yoshinori Otsuki

Publikováno v: Int J Exp Pathol

In clinical medicine, indomethacin (IND, a non‐steroidal anti‐inflammatory drug) is used variously in the treatment of severe osteoarthritis, rheumatoid arthritis, gouty arthritis or ankylosing spondylitis. A common complication found alongside t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91cbc75879a7c2f36d2109a02f71628
https://pubmed.ncbi.nlm.nih.gov/32985762

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Expression of delta-like 3 is downregulated by aberrant DNA methylation and histone modification in hepatocellular carcinoma

Autor: Masa-Aki Shibata, Kentaro Maemura, Yoshinori Otsuki, Michihiro Hayashi, Hiroki Hamamoto, Sugiko Futaki, Kazuhisa Uchiyama, Kohei Taniguchi, Yoichi Kondo, Yutaka Mizuno, Yoshihisa Tanaka, Azumi Hirata

Publikováno v: Oncology Reports.

Delta-like 3 (DLL3) is a member of the Delta/Serrate/Lag-2 family of ligands for the Notch receptor and plays a role in Notch signaling. We have previously revealed that the expression of DLL3 is silenced by aberrant DNA methylation and that overexpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ce07172bf769544f5cdd1c8b664d61
https://doi.org/10.3892/or.2018.6293

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Delta-like 3 is silenced by HBx via histone acetylation in HBV-associated HCCs

Autor: Kazuhisa Uchiyama, Yoshihisa Tanaka, Yoichi Kondo, Kentaro Maemura, Akira Asai, Kentaro Matsuo, Sugiko Futaki, Yoshinobu Hirose, Kohei Taniguchi, Hiroki Hamamoto, Atsushi Takeshita, Michihiro Hayashi

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. We previously showed that expression of Delta-like 3 (DLL3), a member of the family of Delta/Serrate/Lag2 ligands for the Notch receptor, is silenced by aberrant DNA meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9123a3ea14b5c32686143101d608073e
https://pubmed.ncbi.nlm.nih.gov/29555949

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Synthetic α-mangostin dilaurate strongly suppresses wide-spectrum organ metastasis in a mouse model of mammary cancer

Autor: Junji Morimoto, Hitomi Hamaoka, Kentaro Maemura, Munekazu Iinuma, Masa-Aki Shibata, Yoichi Kondo, Yuko Ito, Tadashi Kanayama

Publikováno v: Cancer Science

We previously reported that, in a mouse model of mammary cancer, α-mangostin alone exhibits anti-metastatic properties. To enhance this anti-metastatic effect, we examined the efficacy of synthetic α-mangostin dilaurate (MGD), prepared by adding la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea1b8a901879bd5de6639ff5d6771af
https://pubmed.ncbi.nlm.nih.gov/29601143

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Quantified kidney echogenicity in mice with renal ischemia reperfusion injury: evaluation as a noninvasive biomarker of acute kidney injury

Autor: Kentaro Maemura, Yoshinori Otsuki, Noriyuki Sugiyama, Shinya Murata

Publikováno v: Medical molecular morphology. 50(3)

The purpose is to evaluate quantified kidney echogenicity as a biomarker for the early diagnosis of acute kidney injury (AKI) and predicting progression to chronic kidney disease (CKD) in a mouse model of ischemia–reperfusion injury (IRI). Two sepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744910814cc7f8a5cfee71a189fd980b
https://pubmed.ncbi.nlm.nih.gov/28382533

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