Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kenta Tsunekuni"'
Autor:
Takeshi Wakasa, Kentaro Nonaka, Akihito Harada, Yasuyuki Ohkawa, Chie Kikutake, Mikita Suyama, Takashi Kobunai, Kenta Tsunekuni, Kazuaki Matsuoka, Yuki Kataoka, Hiroaki Ochiiwa, Kazutaka Miyadera, Takeshi Sagara, Eiji Oki, Shigehiro Ohdo, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The fluorinated thymidine analog trifluridine (FTD) is a chemotherapeutic drug commonly used to treat cancer; however, the mechanism by which FTD induces cytotoxicity is not fully understood. In addition, the effect of gain-of-function (GOF)
Externí odkaz:
https://doaj.org/article/d0e4286119c6423db3d09770e905d4cc
Autor:
Kenta Tsunekuni, Masamitsu Konno, Naotsugu Haraguchi, Jun Koseki, Ayumu Asai, Kazuaki Matsuoka, Takashi Kobunai, Teiji Takechi, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Cancer stem cells (CSCs) are involved in metastatic colorectal cancer recurrence, but no effective therapy targeting these cells is currently available. Because trifluridine (FTD)/tipiracil therapy is used for refractory colorectal cancer, w
Externí odkaz:
https://doaj.org/article/57752e7b4a7f4f24852730100fc831b5
Autor:
Kenta Tsunekuni, Hisato Kawakami, Kazuaki Matsuoka, Hideki Nagase, Seiichiro Mitani, Kazuhiko Nakagawa
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 12, p 4050 (2020)
Trifluridine/tipiracil (FTD/TPI) (a.k.a. TAS-102) is a combination drug for metastatic colorectal cancer (CRC) and severely pretreated metastatic gastric/gastroesophageal junction (GEJ) cancers, comprising FTD, a thymidine-based antineoplastic nucleo
Externí odkaz:
https://doaj.org/article/1c2b598bb74f4810ac7163f56ca32670
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163961 (2016)
In colorectal cancer chemotherapy, the current standard of care includes combination therapy with 5-fluorouracil (5-FU) and leucovorin (LV). However, the factors that determine the LV-mediated enhancement of 5-FU antitumor activity are not fully unde
Externí odkaz:
https://doaj.org/article/c88c7e8d115c4e71a47de4cc1d9fd6f3
Autor:
Hideki Nagase, Hisato Kawakami, Kazuhiko Nakagawa, Kenta Tsunekuni, Kazuaki Matsuoka, Seiichiro Mitani
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 4050, p 4050 (2020)
Journal of Clinical Medicine
Volume 9
Issue 12
Journal of Clinical Medicine
Volume 9
Issue 12
Trifluridine/tipiracil (FTD/TPI) (a.k.a. TAS-102) is a combination drug for metastatic colorectal cancer (CRC) and severely pretreated metastatic gastric/gastroesophageal junction (GEJ) cancers, comprising FTD, a thymidine-based antineoplastic nucleo
Autor:
Jun Koseki, Hideshi Ishii, Masamitsu Konno, Yuichiro Doki, Koichi Kawamoto, Kenta Tsunekuni, Ayumu Asai, Satoshi Obika, Naohiro Horie, Masaki Mori
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Halogen-modified nucleic acid molecules, such as trifluorothymidine (FTD) and 5-fluorouracil, are widely used in medical science and clinical site. These compounds have a very similar nucleobase structure. It is reported that both of these compounds
Autor:
Katsunao Tanaka, Noriyasu Hirasawa, Daisuke Kajiwara, Kenta Tsunekuni, Kazuhisa Miyoshi, Hiroki Aoyagi
Publikováno v:
European journal of pharmacology. 875
Nasal obstruction is one of the most bothersome symptoms of allergic rhinitis (AR) affecting sleep-related quality of life in AR patients. Although several treatments were tested to control nasal obstruction, some patients with moderate to severe AR
Autor:
Kenta Tsunekuni, Masaki Mori, Teiji Takechi, Masamitsu Konno, Ayumu Asai, Takashi Kobunai, Jun Koseki, Hideshi Ishii, Yuichiro Doki
Publikováno v:
Oncotarget
// Kenta Tsunekuni 1, 2, 3, * , Masamitsu Konno 1, 4, * , Ayumu Asai 1, 2, 4 , Jun Koseki 2 , Takashi Kobunai 3 , Teiji Takechi 3 , Yuichiro Doki 1 , Masaki Mori 1 and Hideshi Ishii 1, 2 1 Department of Gastroenterological Surgery, Osaka University G
Autor:
Naotsugu Haraguchi, Kazuaki Matsuoka, Takashi Kobunai, Teiji Takechi, Kenta Tsunekuni, Ayumu Asai, Hideshi Ishii, Masaki Mori, Jun Koseki, Yuichiro Doki, Masamitsu Konno
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Cancer stem cells (CSCs) are involved in metastatic colorectal cancer recurrence, but no effective therapy targeting these cells is currently available. Because trifluridine (FTD)/tipiracil therapy is used for refractory colorectal cancer, we sought
Autor:
Takashi Kobunai, Kenta Tsunekuni, Hidetoshi Eguchi, Teiji Takechi, Yuichiro Doki, Masaki Mori, Kazuaki Matsuoka, Hideshi Ishii
Publikováno v:
Cancer Research. 80:5266-5266
Background: Trifluridine (FTD) is a key component of the novel, orally-administered, antitumor drug trifluridine/tipiracil, and is approved for treatment of patients with metastatic colorectal and gastric/GEJ cancers refractory to standard chemothera