Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Kent W, Hunter"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Breast cancer is the most frequently diagnosed cancer worldwide, constituting 15% of cases in 2023. The predominant cause of breast cancer-related mortality is metastasis, and a lack of metastasis-targeted therapies perpetuates dismal outcom
Externí odkaz:
https://doaj.org/article/aa03e11f096f45bca2a6989e6e53387a
Autor:
Megan R Majocha, Devin E Jackson, Ngoc-Han Ha, Ruhul Amin, Marie Pangrácová, Christina R Ross, Howard H Yang, Maxwell P Lee, Kent W Hunter
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011236 (2024)
Patients with ER-negative breast cancer have the worst prognosis of all breast cancer subtypes, often experiencing rapid recurrence or progression to metastatic disease shortly after diagnosis. Given that metastasis is the primary cause of mortality
Externí odkaz:
https://doaj.org/article/6290cedd334c4525803ae30e670a3c1c
Autor:
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D. Tran, Debasish Paul, Steven D. Cappell, Sandra Burkett, Huaitian Liu, Maxwell P. Lee, Michael J. Kruhlak, Jennifer E. Dwyer, R. Mark Simpson, Gordon L. Hager, Yijun Ruan, Kent W. Hunter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and chro
Externí odkaz:
https://doaj.org/article/53398503c4ff4121a84866fffaede387
Autor:
Vanesa C Sanchez, Howard H Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L Carofino, Justin Lack, Jennifer E Dwyer, R Mark Simpson, Christophe Cataisson, Max P Lee, Ji Luo, Kent W Hunter, Stuart H Yuspa
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010271 (2022)
The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to show that CLIC4 expression was higher in breast ca
Externí odkaz:
https://doaj.org/article/a8c9af69453d42e7a8a1e57bff679371
Autor:
Alfredo A Molinolo, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary C Hartman, Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Rashna Madan, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Carol A Lange, Christy R Hagan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formatio
Externí odkaz:
https://doaj.org/article/3ebc51e37c9e47cf891b9468adc3f631
Autor:
Navdeep Malik, Young-Im Kim, Hualong Yan, Yu-Chou Tseng, Wendy du Bois, Gamze Ayaz, Andy D. Tran, Laura Vera-Ramirez, Howard Yang, Aleksandra M. Michalowski, Michael Kruhlak, Maxwell Lee, Kent W. Hunter, Jing Huang
Publikováno v:
Cancer Research. 83:1280-1298
Understanding functional interactions between cancer mutations is an attractive strategy for discovering unappreciated cancer pathways and developing new combination therapies to improve personalized treatment. However, distinguishing driver gene pai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0193cbcaa009ab8c86f5d66b856959cd
https://doi.org/10.1158/0008-5472.can-22-2525
https://doi.org/10.1158/0008-5472.can-22-2525
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Highly metastatic dormant cancer cells contribute to breast cancer recurrence, but the underlying mechanism is less understood. Here, the authors show that dormant breast cancer cells depend on autophagy to ensure their long term survival and distant
Externí odkaz:
https://doaj.org/article/46452b335b2f42b194949651edfe435a
Autor:
Sarah K Deasy, Ryo Uehara, Suman K Vodnala, Howard H Yang, Randall A Dass, Ying Hu, Maxwell P Lee, Robert J Crouch, Kent W Hunter
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008020 (2019)
Breast cancer is the second leading cause of cancer-related deaths in the United States, with the majority of these deaths due to metastatic lesions rather than the primary tumor. Thus, a better understanding of the etiology of metastatic disease is
Externí odkaz:
https://doaj.org/article/7fc1f39e47db4d12859bc6251ad6b458
Autor:
Jing Huang, Kent W. Hunter, Maxwell Lee, Michael Kruhlak, Aleksandra M. Michalowski, Howard Yang, Laura Vera-Ramirez, Andy D. Tran, Gamze Ayaz, Wendy du Bois, Yu-Chou Tseng, Hualong Yan, Young-Im Kim, Navdeep Malik
This is supplementary Table 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ddb34c34ca6f21403157cdd129a960
https://doi.org/10.1158/0008-5472.22633260
https://doi.org/10.1158/0008-5472.22633260
Autor:
Jing Huang, Kent W. Hunter, Maxwell Lee, Michael Kruhlak, Aleksandra M. Michalowski, Howard Yang, Laura Vera-Ramirez, Andy D. Tran, Gamze Ayaz, Wendy du Bois, Yu-Chou Tseng, Hualong Yan, Young-Im Kim, Navdeep Malik
This file contains supplementary figure 1-9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c641bc40c083ae29ab3d13a287ebd48
https://doi.org/10.1158/0008-5472.22633272.v1
https://doi.org/10.1158/0008-5472.22633272.v1