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Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose
Autor:
Joseph Brown, Jackie J. Eckblad, Patrick Priem, Jolanda Gerritsen, Michael Gramer, Carrie Shultz, Kent Vickerman, Ewald T. J. van den Bremer, Patrick Van Berkel, Ruth Donahue
Publikováno v:
Biotechnology and Bioengineering. 108:1591-1602
Through process transfer and optimization for increased antibody production to 3 g/L for a GS-CHO cell line, an undesirable drop in antibody Fc galactosylation was observed. Uridine (U), manganese chloride (M), and galactose (G), constituents involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843196d8fe94ca2cf92b9a05ec7df625
https://doi.org/10.1002/bit.23075
https://doi.org/10.1002/bit.23075
