Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kent T Symons"'
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Fig. S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0239cd0b9e59719d73ad9a95a451c7a2
https://doi.org/10.1158/1535-7163.22485309
https://doi.org/10.1158/1535-7163.22485309
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Table S1 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2d0b912497ade790e8191dc8a1a6a
https://doi.org/10.1158/1535-7163.22485300
https://doi.org/10.1158/1535-7163.22485300
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Fig. S2 from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a60f07e9e7e82703e95fa9acf75dbf
https://doi.org/10.1158/1535-7163.22485306.v1
https://doi.org/10.1158/1535-7163.22485306.v1
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Supplementary Methods from KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14bc54c95af4c3db718bbfdaab0ab55
https://doi.org/10.1158/1535-7163.22485303.v1
https://doi.org/10.1158/1535-7163.22485303.v1
Autor:
Jeffrey H. Hager, Nicholas D. Smith, Tadimeti S. Rao, Stewart A. Noble, Andrew K. Shiau, Jerry Muhammad, Robert L. Davis, James W. Malecha, Alan Saven, Brandon M. Wiley, Sara J. Dozier, Timothy Z. Hoffman, Elena L. Milkova, John V. Anzola, Yan Wang, Carol Trotter, Céline Bonnefous, David A. Jenkins, Joseph E. Payne, Paul L. Wash, Tami Annable, Phan-Manh Nguyen, Xin Guo, Kent T. Symons, Christian A. Hassig
Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of cutaneous T-cell lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f183e54b1bbd2454f1a4fe5e3e9de
https://doi.org/10.1158/1535-7163.c.6531885.v1
https://doi.org/10.1158/1535-7163.c.6531885.v1
Autor:
Kristen A. Baltgalvis, Vincent M. Crowley, Michael A. Schafroth, Brian E. Nordin, Benjamin F. Cravatt, Christie L Eissler, Joe L Rodriguez, Shota Kikuchi, Xiaoyu Zhang, Thomas G Wucherpfennig, Todd Kinsella, Kent T Symons, Melissa M. Dix, David S. Weinstein, Dean Stamos, Gabriel M. Simon, Yu Yamashita, Ludwig Bauer, Lena M Luukkonen
Publikováno v:
J Am Chem Soc
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have bee
Autor:
Christie L Eissler, Todd Kinsella, Gabe Simon, Colin Walsh, Joseph Klebba, Joel Chick, Ali Tabatabaei, Lena M Luukkonen, Landon Whitby, Kent T Symons, Kristen A. Baltgalvis, Yuta Naro, Matthew P. Patricelli, Larry Burgess, Dean Stamos, Joon Chang, Shota Kikuchi, Jaclyn Brannon, Charles Chapman, Brian E. Nordin
Publikováno v:
Cancer Research. 80:6411-6411
Introduction: Targeted protein degradation is a novel therapeutic modality that holds great promise. Current bispecific degraders have been mostly built using reversible ligands against two well characterized E3 ligases, CRBN and VHL. Features unique
Autor:
Nahid Yazdani, Peter J. Rix, Sergio G. Duron, Celine Bonnefous, Xiaohong Chen, Kent T. Symons, Yan Zhang, Hui Zhang, Li Wang, Stewart A. Noble, Nicholas D. Smith, Christian A. Hassig, Andrew K. Shiau, Natasha Rozenkrants, Tadimeti S. Rao, Andrew K. Lindstrom, Marciano Sablad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1237-1241
The overproduction of nitric oxide during the biological response to inflammation by the nitric oxide synthase (NOS) enzymes have been implicated in the pathology of many diseases. By removal of the amide core from uHTS-derived quinolone 4, a new ser
Autor:
Christian A. Hassig, Marciano Sablad, Li Wang, Phan M. Nguyen, Celine Bonnefous, Joseph E. Payne, Kent T. Symons, Nahid Yazdani, Stewart A. Noble, Tadimeti S. Rao, Andrew K. Shiau, Yan Zhang, Natasha Rozenkrants, Nicholas D. Smith, Peter J. Rix
Publikováno v:
Journal of Medicinal Chemistry. 53:7739-7755
Three isoforms of nitric oxide synthase (NOS), dimeric enzymes that catalyze the formation of nitric oxide (NO) from arginine, have been identified. Inappropriate or excessive NO produced by iNOS and/or nNOS is associated with inflammatory and neurop
Autor:
Kent T. Symons, Li Wang, Christian A. Hassig, Joseph E. Payne, Yan Zhang, Steven Dorow, Andrew K. Shiau, Nicholas D. Smith, Celine Bonefous, Nahid Yazdani, Lena M. Staszewski, Peter J. Rix, Natasha Rozenkrants, Phan M. Nguyen, Marciano Sablad, John V. Anzola, Jerry Muhammad, Tadimeti S. Rao, Mark E. Massari, Stewart A. Noble
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 336(2)
Nitric oxide (NO) derived from neuronal nitric-oxide synthase (nNOS) and inducible nitric-oxide synthase (iNOS) plays a key role in various pain and inflammatory states. KLYP961 (4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquin