Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kent Jardemark"'
Autor:
Oscar Jungholm, Carolina Trkulja, Martin Moche, Sreesha P. Srinivasa, Maria-Nefeli Christakopoulou, Max Davidson, Anna Reymer, Kent Jardemark, Rafaela Lenza Fogaça, Anaswara Ashok, Gavin Jeffries, Henry Ampah-Korsah, Emilia Strandback, Juni Andréll, Tomas Nyman, Ghada Nouairia, Owe Orwar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract KRAS belongs to a family of small GTPases that act as binary switches upstream of several signalling cascades, controlling proliferation and survival of cells. Mutations in KRAS drive oncogenesis, especially in pancreatic, lung, and colorect
Externí odkaz:
https://doaj.org/article/724fadc82bd04c76965a6391e880ce3b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Muscle fiber force production is determined by the excitation frequency of motor nerves, which induce transient increases in cytoplasmic free Ca2+ concentration ([Ca2+]i) and the force-generating capacity of the actomyosin cross-bridges. Pre
Externí odkaz:
https://doaj.org/article/6dfb5485f73b4b6fb19dcf1020b41c03
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102260- (2023)
Summary: Here, we provide a protocol for isolation of mouse primary skeletal muscle fibers using two alternative approaches—enzymatic dissociation or mechanical microdissection. We describe the procedures for surgical removal of muscle of interest
Externí odkaz:
https://doaj.org/article/51845cdcad344350be0a73a7630e3a64
Autor:
Monica Llano-Diez, Jon Sinclair, Takashi Yamada, Mei Zong, Jeremy Fauconnier, Shi-Jin Zhang, Abram Katz, Kent Jardemark, Håkan Westerblad, Daniel C Andersson, Johanna T Lanner
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167090 (2016)
The metabolic syndrome is associated with prolonged stress and hyperactivity of the sympathetic nervous system and afflicted subjects are prone to develop cardiovascular disease. Under normal conditions, the cardiomyocyte response to acute β-adrener
Externí odkaz:
https://doaj.org/article/2afc145d9b3f4b469f213fe4608f64ef
Autor:
Max Gubert Olivé, Sophie Erhardt, Holger Wigström, Göran Engberg, Sophie Imbeault, Oscar Jungholm, Kent Jardemark
Publikováno v:
International Journal of Tryptophan Research, Vol 14 (2021)
International Journal of Tryptophan Research : IJTR
International Journal of Tryptophan Research : IJTR
Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice with elevated levels of KYNA, induced by targete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad8570af43556daa3692bcaa64aa208
https://doaj.org/article/ab482d476eaa495797cf5869b7879e04
https://doaj.org/article/ab482d476eaa495797cf5869b7879e04
Autor:
Anna Reymer, Anders Karlsson, Anaswara Ashok, Emma Johnsson, Jessica Hägglund, Joseph D. Bruton, Roger Karlsson, Kent Jardemark, Sreesha P. Srinivasa, Monica M. Marcus, Niklas Ivarsson, Max Davidson, Alexandra Cavallin, Daniela Papadia, Maria-Nefeli Christakopoulou, Carolina Trkulja, Gavin D. M. Jeffries, Oscar Jungholm, Owe Orwar, Peder Svensson, Gabriella Willman
Publikováno v:
Science Advances
This newly developed biological probes/proteomics method yields functional antibodies targeting previously undruggable targets.
Several important drug targets, e.g., ion channels and G protein–coupled receptors, are extremely difficult to appr
Several important drug targets, e.g., ion channels and G protein–coupled receptors, are extremely difficult to appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eee435e07f64b09fb51d7390a5a75f
https://doi.org/10.1126/sciadv.abe6397
https://doi.org/10.1126/sciadv.abe6397
Autor:
Duygu B. Bas, Lu Zhang, Azar Baharpoor, Anne-Julie Chabot-Doré, Jon Sinclair, Mark S. Cragg, Rikard Holmdahl, Lars E. Borm, Kutty Selva Nandakumar, Bingze Xu, Kent Jardemark, Carlos Morado Urbina, Alex Bersellini Farinotti, Johanna T. Lanner, Luda Diatchenko, Simone Codeluppi, Johan Lengqvist, Kristina Ängeby Möller, Gustaf Wigerblad, Mattias Collin, Ia Khmaladze, Kim Kultima, Sally Abdelmoaty, Camilla I. Svensson, Diana S. Nascimento, Katalin Sándor, Birgitta Heyman, Juan Miguel Jimenez-Andrade, Matthew A Hunt, Fredrik Wermeling, Inna Belfer
Publikováno v:
Journal of Experimental Medicine; 216(8), pp 1904-1924 (2019)
The Journal of Experimental Medicine
The Journal of Experimental Medicine
This work elucidates a novel pain mechanism generated by rheumatoid arthritis–associated autoantibodies, uncoupled from inflammation, that is dependent on immune complex formation and activation of neuronal FcγRI.
Rheumatoid arthritis–assoc
Rheumatoid arthritis–assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0920d49670cf131a73e05cf04dc6d933
Autor:
Ninni Påhlsson, Monica M. Marcus, Kent Jardemark, Anna Malmerfelt, Björn Schilström, Annie Möller, Kristin Feltmann, Carl Björkholm, Åsa Konradsson-Geuken, Torgny H. Svensson
Publikováno v:
European Neuropsychopharmacology. 26:1401-1411
Nicotine has been found to improve cognition and reduce negative symptoms in schizophrenia and a genetic and pathophysiological link between the α7 nicotinic acetylcholine receptors (nAChRs) and schizophrenia has been demonstrated. Therefore, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8676c062342f73012da4868164b7327
https://doi.org/10.1016/j.euroneuro.2016.07.004
https://doi.org/10.1016/j.euroneuro.2016.07.004
Autor:
Owe Orwar, Aldo Jesorka, Alar Ainla, Holger Wigström, Gavin D. M. Jeffries, Kent Jardemark, Aikeremu Ahemaiti
Publikováno v:
Journal of Neuroscience Methods. 241:132-136
Background: Among the various fluidic control technologies, microfluidic devices are becoming powerful tools for pharmacological studies using brain slices, since these devices overcome traditional limitations of conventional submerged slice chambers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16f6d5bf747fc742cabf81efea49650
https://doi.org/10.1016/j.jneumeth.2014.12.017
https://doi.org/10.1016/j.jneumeth.2014.12.017
Autor:
Kent Jardemark, Alar Ainla, Aikeremu Ahemaiti, Holger Wigström, Aldo Jesorka, Owe Orwar, Gavin D. M. Jeffries
Publikováno v:
Journal of Neuroscience Methods. 219:292-296
We have developed a superfusion method utilizing an open-volume microfluidic device for administration of pharmacologically active substances to selected areas in brain slices with high spatio-temporal resolution. The method consists of a hydrodynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864223038d46ea0c2ff639a4fc092338
https://doi.org/10.1016/j.jneumeth.2013.08.012
https://doi.org/10.1016/j.jneumeth.2013.08.012