Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kent G. Golic"'
Autor:
Hunter J. Hill, Kent G. Golic
Publikováno v:
Cells, Vol 11, Iss 22, p 3550 (2022)
It has been 70 years since the concept of varied centromere strengths was introduced based on the behavior of dicentric chromosomes. One of the key conclusions from those early experiments was that some centromeres could pull with sufficient force to
Externí odkaz:
https://doaj.org/article/a851144c14804b4ca2876ab7f2753e82
Publikováno v:
GENETICS. 224
Chromosome breakage plays an important role in the evolution of karyotypes and can produce deleterious effects within a single individual, such as aneuploidy or cancer. Forces that influence how and where chromosomes break are not fully understood. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76eb568e9eb475fd8ce7d93c1844bbde
https://doi.org/10.1093/genetics/iyad052
https://doi.org/10.1093/genetics/iyad052
Chromosome breakage plays an important role in the evolution of karyotypes, and can produce deleterious effects within a single individual, such as aneuploidy or cancer. Forces that influence how and where chromosomes break are not well understood. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64566cf93fd20bb0eec8fb3dfb3ca5da
https://doi.org/10.1101/2022.10.13.512123
https://doi.org/10.1101/2022.10.13.512123
Autor:
Yinghua Su, Ho-Chen Lin, Li Szhen Teh, Fabienne Chevance, Ian James, Clara Mayfield, Kent G. Golic, James Gagnon, Ofer Rog, Colin Dale
Publikováno v:
Curr Biol
Many insects maintain mutualistic associations with bacterial endosymbionts, but little is known about how they originate in nature. In this study, we describe the establishment and manipulation of a synthetic insect-bacterial symbiosis in a weevil h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dda49cbe1affb98b92991e096e537a
https://europepmc.org/articles/PMC10080585/
https://europepmc.org/articles/PMC10080585/
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005400 (2015)
The tumor suppressor P53 is a critical mediator of the apoptotic response to DNA double-strand breaks through the transcriptional activation of pro-apoptotic genes. This mechanism is evolutionarily conserved from mammals to lower invertebrates, inclu
Externí odkaz:
https://doaj.org/article/a2b7c04a82db49d18037d8a1ff253eb3
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004130 (2014)
When a dicentric chromosome breaks in mitosis, the broken ends cannot be repaired by normal mechanisms that join two broken ends since each end is in a separate daughter cell. However, in the male germline of Drosophila melanogaster, a broken end may
Externí odkaz:
https://doaj.org/article/64efbc7088d7434aaf0915f56f4780c2
Autor:
Heng B Xie, Anthony Cammarato, Namakkal S Rajasekaran, Huali Zhang, Jennifer A Suggs, Ho-Chen Lin, Sanford I Bernstein, Ivor J Benjamin, Kent G Golic
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003544 (2013)
Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts. The cellular mechanisms of disease pathology for these disorders a
Externí odkaz:
https://doaj.org/article/4789041d94c142bda94469f8185de730
Publikováno v:
Genetics
Site-specific recombinases are widely used tools for analysis of genetics, development, and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because the FRT and lox target sites for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f654cee94b6bdfe4ec68dfe9fbee0b2
https://europepmc.org/articles/PMC7404229/
https://europepmc.org/articles/PMC7404229/
Site-specific recombinases are widely used tools for analysis of genetics, development and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because theFRTandloxtarget sites for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::184943fceb277cbc1b908411dd80caee
https://doi.org/10.1101/2020.05.27.112383
https://doi.org/10.1101/2020.05.27.112383
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002103 (2011)
The mechanisms that cells use to monitor telomere integrity, and the array of responses that may be induced, are not fully defined. To date there have been no studies in animals describing the ability of cells to survive and contribute to adult organ
Externí odkaz:
https://doaj.org/article/643efee669cb491b8bcbac9d8096c0fb