Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Kent E, Kester"'
Autor:
Robert A. van den Berg, Margherita Coccia, W. Ripley Ballou, Kent E. Kester, Christian F. Ockenhouse, Johan Vekemans, Erik Jongert, Arnaud M. Didierlaurent, Robbert G. van der Most
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The RTS,S candidate malaria vaccine can protect against controlled human malaria infection (CHMI), but how protection is achieved remains unclear. Here, we have analyzed longitudinal peripheral blood transcriptome and immunogenicity data from a clini
Externí odkaz:
https://doaj.org/article/2f19e59164d4470d8b75b1ab0fba6f09
Autor:
Robert A. van den Berg, Geert Leroux-Roels, David J. M. Lewis, Stefan H. E. Kaufmann, Hans-Joachim Mollenkopf, Ingileif Jonsdottir, Aldona Greenwood, Catherine Linley, Giuseppe Del Giudice, Kat Pizzoferro, Caroline L. Bodinham, Kent E. Kester, Jeroen Maertzdorf, January Weiner, Alberto Mantovani, Barbara Bottazzi, Philippe Denoel
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpatient clinical studies (NCT01765413/NCT017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb82a2ccd27deedea20670fbdf7b86c
http://link.springer.com/article/10.1038/s41598-019-56994-8
http://link.springer.com/article/10.1038/s41598-019-56994-8
Autor:
Bruce L. Innis, Thomas P. Monath, Jerome H. Kim, Mark A. Marchionni, M. Cristina Cassetti, Alan D.T. Barrett, Melanie Saville, Matthew J. Hepburn, Kent E. Kester, Marcia A. Blackman, James F. Cummings, John Gilly, John R. Mascola, Stephen J. Thomas
Publikováno v:
Vaccine
Emerging and re-emerging infectious diseases are an expanding global threat to public health, security, and economies. Increasing populations, urbanization, deforestation, climate change, anti-vaccination movements, war, and international travel are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e3df4ae6551ba3ca219bda9c4b0541
http://europepmc.org/articles/PMC7131820
http://europepmc.org/articles/PMC7131820
Autor:
Michael T White, Philip Bejon, Ally Olotu, Jamie T Griffin, Eleanor M Riley, Kent E Kester, Christian F Ockenhouse, Azra C Ghani
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61395 (2013)
Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels of antibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP). Using a biologically-motivated mathematical model of sporozoite infection fitted to data
Externí odkaz:
https://doaj.org/article/2d63588eea8b43938f87933b1689e6fa
Autor:
Robert C. Read, Alison R Hill, Andrew T M Vaughan, Diane Gbesemete, Muktar Ibrahim, Guy A. M. Berbers, Hans de Graaf, Anne-Marie Buisman, Andrew Gorringe, Kent E. Kester, Dimitri A. Diavatopoulos, Saul N. Faust, Andrew Preston
Publikováno v:
Clinical Infectious Diseases, 71, 2, pp. 403-411
Clinical Infectious Diseases
Clin Infect Dis
Clinical Infectious Diseases, 71, 403-411
Clinical Infectious Diseases
Clin Infect Dis
Clinical Infectious Diseases, 71, 403-411
Background Bordetella pertussis is among the leading causes of vaccine-preventable deaths and morbidity globally. Human asymptomatic carriage as a reservoir for community transmission of infections might be a target of future vaccine strategies, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505247258302b4dec841398f7d25f7b0
https://hdl.handle.net/2066/225112
https://hdl.handle.net/2066/225112
Autor:
Johan Vekemans, Kent E. Kester, Jason A. Regules, Marc Lievens, Carolyn M. Nielsen, Christian F. Ockenhouse
Publikováno v:
Vaccine
Although RTS,S remains the most advanced malaria vaccine, the factors influencing differences in vaccine immunogenicity or efficacy between individuals or populations are still poorly characterised. The analyses of genetic determinants of immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e304bb94643c43523f15f8b996f014b
https://doi.org/10.1016/j.vaccine.2018.01.069
https://doi.org/10.1016/j.vaccine.2018.01.069
Autor:
Joanne M Lumsden, Robert J Schwenk, Lisa E Rein, Philippe Moris, Michel Janssens, Opokua Ofori-Anyinam, Joe Cohen, Kent E Kester, D Gray Heppner, Urszula Krzych
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e20775 (2011)
A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary challenge with infectious sporozoites in 40% of the 80 subjects enrolled in the study. The fre
Externí odkaz:
https://doaj.org/article/15d32dd5c3414b5f9155b9d7893030d0
Autor:
Mark E Polhemus, Shon A Remich, Bernhards R Ogutu, John N Waitumbi, Lucas Otieno, Stella Apollo, James F Cummings, Kent E Kester, Christian F Ockenhouse, Ann Stewart, Opokua Ofori-Anyinam, Isabelle Ramboer, Conor P Cahill, Marc Lievens, Marie-Claude Dubois, Marie-Ange Demoitie, Amanda Leach, Joe Cohen, W Ripley Ballou, D Gray Heppner
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6465 (2009)
BackgroundThis study advances the clinical development of the RTS,S/AS01B candidate malaria vaccine to malaria endemic populations. As a primary objective it compares the safety and reactogenicity of RTS,S/AS01B to the more extensively evaluated RTS,
Externí odkaz:
https://doaj.org/article/84c5f3aac3754964900009e529047c9f
Autor:
Michele D Spring, James F Cummings, Christian F Ockenhouse, Sheetij Dutta, Randall Reidler, Evelina Angov, Elke Bergmann-Leitner, V Ann Stewart, Stacey Bittner, Laure Juompan, Mark G Kortepeter, Robin Nielsen, Urszula Krzych, Ev Tierney, Lisa A Ware, Megan Dowler, Cornelus C Hermsen, Robert W Sauerwein, Sake J de Vlas, Opokua Ofori-Anyinam, David E Lanar, Jack L Williams, Kent E Kester, Kathryn Tucker, Meng Shi, Elissa Malkin, Carole Long, Carter L Diggs, Lorraine Soisson, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, D Gray Heppner
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5254 (2009)
This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1) representing the 3D7 allele formulated with eithe
Externí odkaz:
https://doaj.org/article/3a664d9efe974ec3ad3412a3ecd03c9c
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-6 (2020)
npj Vaccines, Vol 5, Iss 1, Pp 1-6 (2020)
mRNA technologies have the potential to transform areas of medicine, including the prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration of immunogen discovery to rapid response and multiple disease target manufa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd387bc054e86388d7c3e2c40cdb1bee
https://pubmed.ncbi.nlm.nih.gov/32047656
https://pubmed.ncbi.nlm.nih.gov/32047656