Comparative analysis of salivary gland transcriptomes of Phlebotomus orientalis sand flies from endemic and non-endemic foci of visceral leishmaniasis.

Autor: Michaela Vlkova, Michal Sima, Iva Rohousova, Tatiana Kostalova, Petra Sumova, Vera Volfova, Erin L Jaske, Kent D Barbian, Teshome Gebre-Michael, Asrat Hailu, Alon Warburg, Jose M C Ribeiro, Jesus G Valenzuela, Ryan C Jochim, Petr Volf

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2709 (2014)

BackgroundIn East Africa, Phlebotomus orientalis serves as the main vector of Leishmania donovani, the causative agent of visceral leishmaniasis (VL). Phlebotomus orientalis is present at two distant localities in Ethiopia; Addis Zemen where VL is en

Externí odkaz: https://doaj.org/article/f5fc61665c64471d87c427b317856fba

Characteristics of 263K Scrapie Agent in Multiple Hamster Species

Autor: Kimberly D. Meade-White, Kent D. Barbian, Brent Race, Cynthia Favara, Don Gardner, Lara Taubner, Stephen Porcella, Richard Race

Publikováno v: Emerging Infectious Diseases, Vol 15, Iss 2, Pp 207-215 (2009)

Transmissible spongiform encephalopathy (TSE) diseases are known to cross species barriers, but the pathologic and biochemical changes that occur during transmission are not well understood. To better understand these changes, we infected 6 hamster s

Externí odkaz: https://doaj.org/article/f784cb6494df4e51a560c18669199a8c

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model

Autor: Catharine M. Bosio, Benjamin Schwarz, David W Hawman, Atsushi Okumura, Craig Martens, Friederike Feldmann, Kimberly Meade-White, Rebecca Rosenke, Kyle Rosenke, Frederick Hansen, Heinz Feldmann, Kent D. Barbian, Shanna Leventhal, Emily Ricotta, Elaine Haddock, Michael A. Jarvis, Greg Saturday

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Research Square
article-version (status) pre
article-version (number) 1

The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pande

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65fcb4102ea6add6bb7bc2d3053b1ef
http://europepmc.org/articles/PMC8052374

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

Autor: Aaron B. Carmody, Fatima Amanat, Kent D. Barbian, Vincent J. Munster, Jonathan E Schulz, Patrick W. Hanley, Myndi G. Holbrook, Jyothi N. Purushotham, Florian Krammer, Claude Kwe Yinda, Atsushi Okumura, Brian J. Smith, Teresa Lambe, Julia R Port, Trenton Bushmaker, Jamie Lovaglio, Sarah L. Anzick, Neeltje van Doremalen, Craig Martens, Greg Saturday, Sarah C. Gilbert

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1

ChAdOx1 nCoV-19/AZD1222 is an approved adenovirus-based vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being deployed globally. Previous studies in rhesus macaques revealed that intramuscular vaccination with ChAdO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cf6302487ca576ecbd3f6e8c1c5d36
https://pubmed.ncbi.nlm.nih.gov/33447831

Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4

Autor: Kent D. Barbian, Craig Martens, Saifeng Wang, Madeline Wong, Patrick T. Smith, Amir Foroushani, Markus Hafner, Andre Rastegar, Stefan A. Muljo, Bryan Chim

Publikováno v: Proc Natl Acad Sci U S A

The human genome encodes for over 1,500 RNA-binding proteins (RBPs), which coordinate regulatory events on RNA transcripts. Most studies of RBPs have concentrated on their action on host protein-encoding mRNAs, which constitute a minority of the tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa77c07053d9dd210eb1f55abe1718d9
https://pubmed.ncbi.nlm.nih.gov/33020268