Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Kent C. Shih"'
Autor:
Howard L. Kaufman, Jeffery S. Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P. D’Angelo, Kent C. Shih, Céleste Lebbé, Michele Milella, Isaac Brownell, Karl D. Lewis, Jochen H. Lorch, Anja von Heydebreck, Meliessa Hennessy, Paul Nghiem
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-7 (2018)
Abstract Background Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with poor survival outcomes in patients with distant metastatic disease (mMCC). In an initial analysis from JAVELIN Merkel 200, a phase 2, prospective, open-
Externí odkaz:
https://doaj.org/article/8702b9ace3ed4ea195be94aaa6b2d065
Autor:
Janice M Mehnert, Isaac Brownell, Sandra P D'Angelo, Kent C Shih, Karl D Lewis, Gerald P Linette, Sara Georges, Parantu Shah, Barbara Ellers-Lenz, Gülseren Güzel, Paul T Nghiem
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/6b2c18192f054108bb66677b66820f44
Autor:
Janice M Mehnert, Isaac Brownell, Sandra P D'Angelo, Kent C Shih, Karl D Lewis, Gerald P Linette, Sara Georges, Parantu Shah, Barbara Ellers-Lenz, Gülseren Güzel, Paul T Nghiem
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with a high risk of metastasis. In 2017, avelumab (anti–programmed death-ligand 1 (PD-L1)) became the first approved treatment for patients with metastatic MCC (mMC
Externí odkaz:
https://doaj.org/article/38f487d0c8524f31899d14e4888ffca6
Autor:
Janice M Mehnert, Isaac Brownell, Sandra P D'Angelo, Kent C Shih, Karl D Lewis, Gerald P Linette, Sara Georges, Parantu Shah, Barbara Ellers-Lenz, Gülseren Güzel, Paul T Nghiem
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/9cf9c19def3a426f9e73874645c14869
Autor:
Viorel Jinga, Daniel J. Maslyar, Premal H. Patel, Ruth Riisnaes, Steven Gendreau, Han Ma, Wai Y. Chan, Na Xu, George Daniel Radavoi, Kent C. Shih, Jose Angel Arranz Arija, Albert Font, Sergio Bracarda, Christophe Massard, Daniel Nava Rodrigues, Ugo De Giorgi, Johann S. de Bono
Includes supplementary methods, figures, and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04392189dcb36c8a2d6d73fc4c435d1
https://doi.org/10.1158/1078-0432.22468467.v1
https://doi.org/10.1158/1078-0432.22468467.v1
Autor:
Viorel Jinga, Daniel J. Maslyar, Premal H. Patel, Ruth Riisnaes, Steven Gendreau, Han Ma, Wai Y. Chan, Na Xu, George Daniel Radavoi, Kent C. Shih, Jose Angel Arranz Arija, Albert Font, Sergio Bracarda, Christophe Massard, Daniel Nava Rodrigues, Ugo De Giorgi, Johann S. de Bono
Purpose:PI3K–Akt–mTOR and androgen receptor (AR) signaling are commonly aberrantly activated in metastatic castration-resistant prostate cancer (mCRPC), with PTEN loss associating with poor prognosis. We therefore conducted a phase Ib/II study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e77f27f4ec7c9b569f79eefffe9f9c
https://doi.org/10.1158/1078-0432.c.6526956.v1
https://doi.org/10.1158/1078-0432.c.6526956.v1
Autor:
Olaf Witt, Birgit Geoerger, Uta Dirksen, Sameer Farouk Sait, David A. Reardon, Kent C. Shih, Blanca D. Diez, Eliana Maria Monteiro Caran, Shuhei Karakawa, Kim Stuyckens, Huimin Liao, Saltanat Najmi, Constance Hammond, Ademi E. Santiago-Walker, Hussein Sweiti
TPS10058 Background: FGFR gene alterations have been observed in pediatric patients with cancers and represent potentially targetable genomic variants. Gliomas (high- and low-grade) and soft tissue sarcomas are among the pediatric solid tumors that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d614f7c6fcd9ac497462da86f10d62
Autor:
Suzanne F. Jones, Howard A. Burris, Joseph Stilwill, Dianna Shipley, Cindy Jacobs, John D. Hainsworth, David R. Spigel, Brian Hemphill, Kent C. Shih, Patrick J. Ward, Ray D. Page, Tarek Mekhail, Michael McCleod, Robert C. Whorf, David M. Waterhouse
Publikováno v:
The Oncologist. 24:e1409-e1416
Background This randomized, double-blinded, phase II trial evaluated the efficacy of carboplatin and pemetrexed plus either apatorsen, an antisense oligonucleotide targeting heat shock protein (Hsp) 27 mRNA, or placebo in patients with previously unt
Autor:
Kevin P. Becker, John D. Hainsworth, Tarek Mekhail, David Wright, Howard A. Burris, Sajeel A. Chowdhary, Janice Faulkner Eakle, Kimberly West-Osterfield, Gilbert Darin Anthony Padula, Mythili Shastry, Meredith Scarberry, Kent C. Shih, Robert M. Langdon, Candice A. Shaifer, Kathleen Yost
Publikováno v:
Journal of Neuro-Oncology. 144:303-311
Current bevacizumab-based regimens have failed to improve survival in patients with recurrent glioblastoma. To improve treatment efficacy, we evaluated bevacizumab + BKM120, an oral pan-class I PI3K inhibitor, in this patient population. A brief phas
Autor:
Céleste Lebbé, Andrew S. Brohl, Meliessa H. Hennessy, Michele Milella, Patrick Terheyden, Kent C. Shih, Paul Nghiem, Isaac Brownell, Gerald P. Linette, Karl D. Lewis, Shailender Bhatia, Murtuza Bharmal, Omid Hamid, Michael Schlichting, Sandra P. D'Angelo, Janice M. Mehnert, Matthias Hunger
Publikováno v:
Cancer Immunology, Immunotherapy
Background Response rates are primary endpoints in many oncology trials; however, correlation with overall survival (OS) is not uniform across cancer types, treatments, or lines of therapy. This study explored the association between objective respon