Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kent C Sasse"'
Autor:
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo
Publikováno v:
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://doaj.org/article/834ddbe5b2af4b2d9cbfe39b3182cbe7
Autor:
Se Eun Ha, Moon Young Lee, Masaaki Kurahashi, Lai Wei, Brian G Jorgensen, Chanjae Park, Paul J Park, Doug Redelman, Kent C Sasse, Laren S Becker, Kenton M Sanders, Seungil Ro
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182265 (2017)
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. PDGFRα+ cells directly interact w
Externí odkaz:
https://doaj.org/article/50deaf005e3a4a19b5839b7d8a35b6d4
Autor:
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín-Aragón Baudel, Víctor A. Flores-Tamez, Kent C. Sasse, Sean M. Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels, Eamonn J. Dickson, Johannes W. Hell, John D. Scott, Luis F. Santana, Yang K. Xiang, Manuel F. Navedo, Madeline Nieves-Cintrón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and va
Externí odkaz:
https://doaj.org/article/16c1bd62635d42608c4af12cd7cb45a7
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C992-C1006
The main function of the stomach is to digest ingested food. Gastric antrum muscular contractions mix ingested food with digestive enzymes and stomach acid and propel the chyme through the pyloric sphincter at a rate in which the small intestine can
Autor:
Se Eun Ha, Brian G. Jorgensen, Lai Wei, Byungchang Jin, Min-Seob Kim, Sandra M. Poudrier, Rajan Singh, Allison Bartlett, Hannah Zogg, Sei Kim, Gain Baek, Masaaki Kurahashi, Moon-Young Lee, Yong-Sung Kim, Suck-Chei Choi, Kent C. Sasse, Samuel J. S. Rubin, Andres Gottfried-Blackmore, Laren Becker, Aida Habtezion, Kenton M. Sanders, Seungil Ro
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5007 (2022)
Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory peptidase that is almost exclusively expressed in the gastrointestinal (GI) tract. We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDG
Externí odkaz:
https://doaj.org/article/3b9d7495f4dc4c43b12f2780e01c2f2a
Autor:
Miguel, Martín-Aragón Baudel, Victor A, Flores-Tamez, Junyoung, Hong, Gopyreddy R, Reddy, Pauline, Maillard, Abby E, Burns, Kwun Nok Mimi, Man, Kent C, Sasse, Sean M, Ward, William A, Catterall, Donald M, Bers, Johannes W, Hell, Madeline, Nieves-Cintrón, Manuel F, Navedo
Publikováno v:
Circulation research. 131(12)
L-type CaA multiscale approach including patch-clamp electrophysiology, super-resolution nanoscopy, proximity ligation assay, calcium imaging' pressure myography, and Laser Speckle imaging was implemented to examine CaCaThese results suggest that PKA
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Ingested food is received, mixed, and ground into chyme by distinct gastric motility patterns. Diabetes impairs gastric muscle function, but the mechanisms underlying diabetes-induced gastric muscle dysfunction are unknown. Here, we compared the expr
Externí odkaz:
https://doaj.org/article/2f352d4e155d4948b469a8c8876294e2
Autor:
David L. Warner, Kent C. Sasse
Publikováno v:
Minimally Invasive Surgery, Vol 2017 (2017)
Introduction. Laparoscopic sleeve gastrectomy is a widely utilized and effective surgical procedure for dramatic weight loss in obese patients. Leak at the sleeve staple line is the most serious complication of this procedure, occurring in 1–3% of
Externí odkaz:
https://doaj.org/article/58f5aad82976476cb079c3b2d78ff4ca
Autor:
Terry L. Powley, Billie Hunne, Deborah Jaffey, Linda J Fothergill, Kent C. Sasse, Martin J. Stebbing, John B. Furness, Lalita Oparija-Rogenmozere, Sean M. Ward, Madeleine Di Natale
Publikováno v:
Cell Tissue Res
The stomach acts as a buffer between the ingestion of food and its processing in the small intestine. It signals to the brain to modulate food intake and it in turn regulates the passage of a nutrient-rich fluid, containing partly digested food, into
Autor:
Miguel Martín-Aragón Baudel, Peter Bartels, Madeline Nieves-Cintrón, Víctor A. Flores-Tamez, Kent C. Sasse, Nipavan Chiamvimonvat, Johannes W. Hell, G. R. Reddy, John D. Scott, Luis Fernando Santana, Arsalan U. Syed, Eamonn J. Dickson, Maria Paz Prada, Sean M. Ward, Padmini Sirish, Yang Kevin Xiang, Manuel F. Navedo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA, but the underlying mechanisms are unc