Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

Autor: Henrik Rahbek-Nielsen, Jesper Lykkegaard Karlsen, Siv Annegrethe Hjorth, Kent Bondensgaard, Rune Hartmann, Anders Svensson, Lishan Kang, Søren R. Paludan, Ole J. Hamming

Publikováno v: Journal of Biological Chemistry. 287:9454-9460

IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune responses. It signals through a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R) and the common γ-chain. A hallmark of the class I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adc088746a00c80c0cc9b9563767ae7
https://doi.org/10.1074/jbc.m111.311084

Parallel solid-phase synthesis of disubstituted (5-biphenyltetrazolyl) hydantoins and thiohydantoins targeting the growth hormone secretagogue receptor

Autor: Michael Ankersen, Mikael Begtrup, Kent Bondensgaard, Rune Severinsen, Birgit Sehested Hansen, Jesper Lau

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:317-320

An efficient solid-phase protocol for the synthesis of substituted (5-biphenyltetrazolyl)-hydantoins and -thiohydantoins has been developed. Suzuki cross-coupling between resin-bound 2-(tetrazol-5-yl)-phenylborinane and 4-bromobenzaldehyde gave the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deb336e112afa5fe54170cc46cd4e5b
https://doi.org/10.1016/j.bmcl.2003.11.012

The conformations of locked nucleic acids (LNA)

Autor: Michael B. Petersen, Alexei A. Koshkin, Sanjay K. Singh, Katrine E. Nielsen, Britta M. Dahl, Kent Bondensgaard, Jens Peter Jacobsen, Christina B. Nielsen, Jesper Wengel, Gitte A. Jensen, Vivek K. Rajwanshi

Publikováno v: Journal of Molecular Recognition. 13:44-53

We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9521b8e2b6c26ddef508af2613cbad
https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1<44::aid-jmr486>3.0.co

Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope

Autor: Siv Annegrethe Hjorth, Tengkun Li, Rune Hartmann, Kent Bondensgaard, Lishan Kang

Publikováno v: Kang, L, Bondensgaard, K, Li, T, Hartmann, R & Hjorth, S A 2010, ' Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope ', Journal of Biological Chemistry, vol. 285, no. 16, pp. 12223-31 . https://doi.org/10.1074/jbc.M110.101444

The cytokine interleukin (IL)-21 exerts pleiotropic effects acting through innate as well as adaptive immune responses. The activities of IL-21 are mediated through binding to its cognate receptor complex composed of the IL-21 receptor private chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c54e02c5ba4c6f286315385bddd5de
https://pure.au.dk/portal/da/publications/rational-design-of-interleukin21-antagonist-through-selective-elimination-of-the-gammac-binding-epitope(c1837a6b-6cdb-402b-98bd-71582b240f08).html

Comparison of the ability of wild type and stabilized human IgG(4) to undergo Fab arm exchange with endogenous IgG(4)in vitro and in vivo

Autor: Lay Chin, Brent Meengs, Kent Bondensgaard, Steven D. Hughes, Liping Wang, Kenneth B. Lewis, Søren Lund, Birgitte Kjær

Publikováno v: Molecular immunology. 46(16)

Fab arm exchange by a stabilized anti-IL-31 IgG(4)S228P monoclonal antibody (mAb) was studied using physiologically relevant antibody concentrations and thiol exchange conditions, and directly compared to that of matched wild type IgG(4) (IgG(4)wt) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329280dd92ba421b5b3fdfa2076e23c0
https://pubmed.ncbi.nlm.nih.gov/19683345