Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kent A. Gossett"'
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 39:137-141
Pleural pressures are used to evaluate lung function and are generally measured acutely in anesthetized animals. Previous attempts to measure pleural pressure chronically in conscious animals have involved surgical implantation of pressure-sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2085b3a2546a58ba6fb3a678c876e5f6
https://doi.org/10.1016/s1056-8719(98)00008-2
https://doi.org/10.1016/s1056-8719(98)00008-2
Autor:
Neptun D, Batchelor J, Matsuzawa T, Salemink P, Woodman D, Dai Davies, Kurt W. Weingand, Kimball J, Provost Jp, Waner T, Mamoru Nomura, Fabianson-Johnson E, Kent A. Gossett, Dal Negro G, Malcolm York, Lupart M, Froelke W, Robert Hall, Brown G, Boink A, Melloni E, Groetsch H
Publikováno v:
Toxicological Sciences. 29:198-201
Ten scientific organizations formed a joint international committee to provide expert recommendations for clinical pathology testing of laboratory animal species used in regulated toxicity and safety studies. For repeated-dose studies in rodent speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192aa2d67f7cead947d590db103aad2b
https://doi.org/10.1093/toxsci/29.2.198
https://doi.org/10.1093/toxsci/29.2.198
Publikováno v:
Drug Development Research. 35:150-157
General/safety pharmacology is an emerging discipline within the pharmaceutical industry in which unanticipated effects of new drug candidates on major organ function (i.e., secondary pharmacological effects) are critically assessed in a variety of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f75f8d1e350ed807947ffa93e2d50f4
https://doi.org/10.1002/ddr.430350307
https://doi.org/10.1002/ddr.430350307
Publikováno v:
Drug Development Research. 32:208-216
General pharmacology and safety pharmacology studies are of considerable value in drug discovery and safety assessment. The knowledge gained from these studies adds mechanistic perspectives and functional dimensions to contemporary animal pharmacolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436ee3d9275c3e79c054a161513aeb6f
https://doi.org/10.1002/ddr.430320404
https://doi.org/10.1002/ddr.430320404
Publikováno v:
Toxicological Sciences. 20:147-154
Ipazilide fumarate (WIN 54177-4) is a chemically novel antiarrhythmic agent that prolongs ventricular refractoriness and possesses antiectopic activity. The compound is being developed as oral and iv therapy for ventricular and supraventricular arrhy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddbd5e4b11dbdb84dc4e8b3dc2d05c7
https://doi.org/10.1093/toxsci/20.2.147
https://doi.org/10.1093/toxsci/20.2.147
Publikováno v:
Toxicologic Pathology. 19:251-257
Recombinant human interleukin-4 (rhuIL-4) is a candidate for the treatment of refractory cancer based on its potential to enhance the function of the immune system. Total daily dosages of 0 (placebo control), 1, 5, or 25 micrograms/kg of rhuIL-4 were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1200a7af981d4be4a1e3a5ffb06462b4
https://doi.org/10.1177/019262339101900307
https://doi.org/10.1177/019262339101900307
Publikováno v:
Toxicologic pathology. 28(5)
Plasma von Willebrand factor (vWF) was evaluated as a potential biomarker of acute arterial damage in rats after a vasotoxic dose of the dopaminergic vasodilator, fenoldopam (FP). Male Sprague-Dawley rats were given FP or isotonic saline by subcutane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea3ce298a37ab13cd2f99732782fdb6
https://pubmed.ncbi.nlm.nih.gov/11026604
https://pubmed.ncbi.nlm.nih.gov/11026604
Publikováno v:
Toxicologic pathology. 21(1)
Recombinant human interleukin 4 (rhuIL-4) is a candidate for the treatment of refractory cancer based on its potential to enhance immune function. Recombinant human IL-4 was administered subcutaneously at 0, 1, 5, or 25 μg/kg/day for 28 days with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d112e09c9c412e6c00b02750a8c41942
https://pubmed.ncbi.nlm.nih.gov/8378706
https://pubmed.ncbi.nlm.nih.gov/8378706
Publikováno v:
Toxicology letters.
Recombinant human IL-4 (rhuIL-4) is primate-specific and produces multiple biologic effects on lymphoid cells involved in protection against cancer. RhuIL-4 was evaluated in the cynomolgus monkey to support clinical studies for the immunotherapy of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb1c9259c53652890298e9b1ec54ec3
https://pubmed.ncbi.nlm.nih.gov/1471185
https://pubmed.ncbi.nlm.nih.gov/1471185
Publikováno v:
International journal of immunopharmacology. 14(3)
The purpose of this presentation was to review issues and findings in the pre-clinical development and evaluation of recombinant human protein therapeutics. Since human cytokines and lymphokines are endogenous proteins, their pre-clinical development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf8fdf9e25a091a3c240f43aa25dabc
https://pubmed.ncbi.nlm.nih.gov/1618593
https://pubmed.ncbi.nlm.nih.gov/1618593