Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kensuke Sakuma"'
Autor:
Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Kiyohiro Hashimoto, Nozomu Sakai, Shinya Asano, Saori Watanabe-Matsumoto, Takeshi Watanabe, Bunnai Saito, Hirokazu Matsumoto, Hikaru Ueno, Ryo Ito, Taro Toyoda
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the saf
Externí odkaz:
https://doaj.org/article/a21dd5df379540a8874afc1118b6fef0
Autor:
Hideyuki Hiyoshi, Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Shinya Asano, Taisuke Mochida, Junji Yamaura, Shuhei Konagaya, Ryo Fujii, Hirokazu Matsumoto, Ryo Ito, Taro Toyoda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes. Although non-endocrine cells are inevitable contaminating by-product
Externí odkaz:
https://doaj.org/article/230766f713d141caa8dc083eae065981
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Purinergic P2Y 2 receptors, G-protein coupled receptors that primarily couple with Gαq/11-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate. Evidence suggests that P2Y 2 agonists make po
Externí odkaz:
https://doaj.org/article/7318d80836ef4964a22fb41a3fcb7561
Autor:
Masamitsu Fukuyama, Kensuke Sakuma, Riyong Park, Hidefumi Kasuga, Ryotaro Nagaya, Yuriko Atsumi, Yumi Shimomura, Shinya Takahashi, Hiroaki Kajiho, Ann Rougvie, Kenji Kontani, Toshiaki Katada
Publikováno v:
Biology Open, Vol 1, Iss 10, Pp 929-936 (2012)
Summary Mechanisms controlling development, growth, and metabolism are coordinated in response to changes in environmental conditions, enhancing the likelihood of survival to reproductive maturity. Much remains to be learned about the molecular basis
Externí odkaz:
https://doaj.org/article/7f91c3d7b9d5460a8724a09f5751566c
Autor:
Kensuke Sakuma, Hidetoshi Komatsu, Minoru Maruyama, Sachiko Imaichi, Yugo Habata, Masaaki Mori
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118510 (2015)
Various types of antipsychotics have been developed for the treatment of schizophrenia since the accidental discovery of the antipsychotic activity of chlorpromazine. Although all clinically effective antipsychotic agents have common properties to in
Externí odkaz:
https://doaj.org/article/ed7176c9ef344787bc44d3e0a3e07f40
Autor:
Hidetoshi Komatsu, Minoru Maruyama, Shuuhei Yao, Tokuyuki Shinohara, Kensuke Sakuma, Sachiko Imaichi, Tomoko Chikatsu, Kanako Kuniyeda, Foo Kok Siu, Lam Sock Peng, Katherine Zhuo, Lay Sock Mun, Tan Min Han, Yoshio Matsumoto, Tadatoshi Hashimoto, Nobuyuki Miyajima, Yasuaki Itoh, Kazuhiro Ogi, Yugo Habata, Masaaki Mori
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90134 (2014)
Many drugs of abuse and most neuropharmacological agents regulate G protein-coupled receptors (GPCRs) in the central nervous system (CNS)_ENREF_1. The striatum, in which dopamine D1 and D2 receptors are enriched, is strongly innervated by the ventral
Externí odkaz:
https://doaj.org/article/6ff47ac7092a4dd594e33a33889dc4a4
Autor:
Chiori Yabuki, Hidetoshi Komatsu, Yoshiyuki Tsujihata, Risa Maeda, Ryo Ito, Kae Matsuda-Nagasumi, Kensuke Sakuma, Kazumasa Miyawaki, Naoya Kikuchi, Koji Takeuchi, Yugo Habata, Masaaki Mori
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76280 (2013)
Selective free fatty acid receptor 1 (FFAR1)/GPR40 agonist fasiglifam (TAK-875), an antidiabetic drug under phase 3 development, potentiates insulin secretion in a glucose-dependent manner by activating FFAR1 expressed in pancreatic β cells. Althoug
Externí odkaz:
https://doaj.org/article/875ecff2c84d4653af7caf3a7d844768
Autor:
Hideyuki Hiyoshi, Kensuke Sakuma, Shinya Asano, Napier, Stephanie C., Shuhei Konagaya, Taisuke Mochida, Hikaru Ueno, Takeshi Watanabe, Yoshiaki Kassai, Hirokazu Matsumoto, Ryo Ito, Taro Toyoda
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/16/2024, Vol. 121 Issue 16, p1-11, 38p
Publikováno v:
Materials Letters. 300:130178
Ag nanostructure-based surface-enhanced Raman scattering (SERS) substrates tend to be oxidized and corroded by sulfides owing to their large specific surface area, resulting in severe deterioration. Contrastingly, micrometer-sized Ag structures are m
Publikováno v:
The Proceedings of Mechanical Engineering Congress, Japan. 2020:J22206