Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kensuke Ninomiya"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Liquid-liquid phase separation (LLPS) has been thought to be the biophysical principle governing the assembly of the multiphase structures of nucleoli, the site of ribosomal biogenesis. Condensates assembled through LLPS increase their sizes
Externí odkaz:
https://doaj.org/article/8ebec638e73042cea5256fa37ae71f7b
Autor:
Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here the authors show the mechanism by which a small molecule targets the disease-causing r(UGGAA) n repeat RNAs in spinocerebellar ataxia ty
Externí odkaz:
https://doaj.org/article/fb74152ab4824a57b44c57a7b829b312
Publikováno v:
Nature Reviews Molecular Cell Biology. 24:288-304
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to intracellular compartmentalization of specific biological functions. In eukaryote
Autor:
Akihide Takeuchi, Kei Iida, Toshiaki Tsubota, Motoyasu Hosokawa, Masatsugu Denawa, J.B. Brown, Kensuke Ninomiya, Mikako Ito, Hiroshi Kimura, Takaya Abe, Hiroshi Kiyonari, Kinji Ohno, Masatoshi Hagiwara
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1326-1341 (2018)
Summary: Genes specifically expressed in neurons contain members with extended long introns. Longer genes present a problem with respect to fulfilment of gene length transcription, and evidence suggests that dysregulation of long genes is a mechanism
Externí odkaz:
https://doaj.org/article/0a6681dd64c245e2bc31bda9dae37b9f
Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases
Autor:
Kensuke Ninomiya, Tetsuro Hirose
Publikováno v:
Non-Coding RNA, Vol 6, Iss 1, p 6 (2020)
Nuclear bodies are membraneless, phase-separated compartments that concentrate specific proteins and RNAs in the nucleus. They are believed to serve as sites for the modification, sequestration, and storage of specific factors, and to act as organiza
Externí odkaz:
https://doaj.org/article/16be019b22844f5b8f4be7a823154f0c
Autor:
Dan O. Wang, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
RNA transport and regulated local translation play critically important roles in spatially restricting gene expression in neurons. Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in t
Externí odkaz:
https://doaj.org/article/c88a20d712b542bb920e3da4fc941ed3
Autor:
Kensuke Ninomiya, Kazuhiko Nakatani, Yoshitaka Nagai, Morio Ueyama, Tomonori Shibata, Kinya Ishikawa, Tetsuro Hirose, Konami Nagano, Gota Kawai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) targets disease-causing r(UGGAA)n repeat RNAs in spinocerebellar ataxia
Liquid-liquid phase separation (LLPS) has been thought to be the biophysical principle governing the assembly of the multiphase structures of nucleoli, the site of ribosomal biogenesis. Condensates assembled through LLPS increase their sizes to minim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb43eb3bd34a4325b450de35e70f24c
https://doi.org/10.1101/2021.09.09.459702
https://doi.org/10.1101/2021.09.09.459702
Autor:
Kensuke Ninomiya, Goro Terai, Kiyoshi Asai, Mahmoud Khamis Aly, Tohru Natsume, Tetsuro Hirose, Yuriko Sakaguchi, Junichi Iwakiri, Tsutomu Suzuki, Shungo Adachi
Publikováno v:
EMBO J
Nuclear stress bodies (nSBs) are nuclear membraneless organelles formed around stress‐inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs repress splicing of hundreds of introns during thermal stress recovery, which are partly regul
Autor:
Tomonori Shibata, Yoshitaka Nagai, Kinya Ishikawa, Kensuke Ninomiya, Morio Ueyama, Kazuhiko Nakatani, Konami Nagano, Gota Kawai, H. Tetsuro
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) targets disease-causing r(UGGAA)n repeat RNAs in spinocerebellar ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeea3bc0dacc1400e666eadf3810075c
https://doi.org/10.1101/2020.10.05.323261
https://doi.org/10.1101/2020.10.05.323261