Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kensuke Kusumi"'
Autor:
Kensuke Kusumi
Publikováno v:
Bio-Protocol, Vol 3, Iss 9 (2013)
The number of stomata on leaves is known to be affected by various environmental factors and intrinsic developmental program. Stomatal density and stomatal index are generally used as indicators of the leaf development and the plant growth. This prot
Externí odkaz:
https://doaj.org/article/db0bba18be5a4a96882164eefc536bf6
Autor:
Kensuke Kusumi1 kkususcb@kyushu-u.org, Ayana Hashimura1, Yoshiko Yamamoto1, Juntaro Negi1, Koh Iba1
Publikováno v:
Plant & Cell Physiology. Dec2017, Vol. 58 Issue 12, p2085-2094. 10p.
Autor:
Masaharu Komeno, Yuka Takada, Takaki Komiya, Tatsuo Maeda, Haruto Kurata, Ryo Suzuki, Tetsu Kondo, Norikazu Matsunaga, Hiroshi Hagiya, Takeji Ono, Kazuhiro Otsuki, Ken-ici Nunoya, Sachiko Tominaga, Shinji Nakade, Hirotaka Mizuno, Kensuke Kusumi, Hidekazu Kiyoshi, Hiroki Shioya, Masakuni Kurono, Hiromu Habashita
Publikováno v:
Journal of Medicinal Chemistry. 60:9508-9530
The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. Whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93fca9c48ce6fcc55e95a6bf9234011
https://doi.org/10.1021/acs.jmedchem.7b00785
https://doi.org/10.1021/acs.jmedchem.7b00785
Autor:
Kazuhiro Otsuki, Hiroshi Yamamoto, Haruto Kurata, Ai Hashimoto, Koji Shinozaki, Takeshi Matsushita, Takuya Seko, Yoshiyuki Yamaura, Tetsuya Sekiguchi, Kensuke Kusumi, Akito Kakuuchi, Atsushi Naganawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1209-1213
The structure of the S1P2 antagonist 1 has been modified with the aim of improving its oral bioavailability. The chemical modification of the alkyl chain and carboxylic acid moieties of 1 led to significant improvements in the oral exposure of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25a2df178b653cedb5d031676d280d5
https://doi.org/10.1016/j.bmcl.2016.01.031
https://doi.org/10.1016/j.bmcl.2016.01.031
Autor:
Juntaro, Negi, Shintaro, Munemasa, Boseok, Song, Ryosuke, Tadakuma, Mayumi, Fujita, Tamar, Azoulay-Shemer, Cawas B, Engineer, Kensuke, Kusumi, Ikuo, Nishida, Julian I, Schroeder, Koh, Iba
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Guard cells have photosynthetically active chloroplasts in most plant species. However, the significance of their existence in guard cells or their developmental mechanisms is unknown. Here, through a forward-genetic approach, we have id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fdb5a1dab9578afe76de8f3222841b5
https://pubmed.ncbi.nlm.nih.gov/30127035
https://pubmed.ncbi.nlm.nih.gov/30127035
Autor:
Hideyuki Ueda, Ai Hashimoto, Tetsuya Sekiguchi, Kazuhiro Otsuki, Takuya Seko, Kensuke Kusumi, Haruto Kurata, Akito Kakuuchi, Yoshiyuki Yamaura, Atsushi Naganawa, Koji Shinozaki, Takeshi Matsushita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4387-4392
Our initial lead compound 2 was modified to improve its metabolic stability. The resulting compound 5 showed excellent metabolic stability in rat and human liver microsomes. We subsequently designed and synthesized a hybrid compound of 5 and the 1,3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee7eda0e3ed88ff58ed6cf0b673fbb6
https://doi.org/10.1016/j.bmcl.2015.09.022
https://doi.org/10.1016/j.bmcl.2015.09.022
Autor:
Akito Kakuuchi, Haruto Kurata, Kazuhiro Otsuki, Tetsuya Sekiguchi, Atsushi Naganawa, Koji Shinozaki, Takeshi Matsushita, Kensuke Kusumi, Takuya Seko, Kanaji Toshiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1479-1482
The structure–activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The initial hit compound 1 was modified through synthesis to improve its S1P2 activity. The synthesis of a series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe897b0e5487ff42688c85ffea02bdb8
https://doi.org/10.1016/j.bmcl.2015.02.029
https://doi.org/10.1016/j.bmcl.2015.02.029
Autor:
Haruto, Kurata, Kensuke, Kusumi, Kazuhiro, Otsuki, Ryo, Suzuki, Masakuni, Kurono, Takaki, Komiya, Hiroshi, Hagiya, Hirotaka, Mizuno, Hiroki, Shioya, Takeji, Ono, Yuka, Takada, Tatsuo, Maeda, Norikazu, Matsunaga, Tetsu, Kondo, Sachiko, Tominaga, Ken-Ici, Nunoya, Hidekazu, Kiyoshi, Masaharu, Komeno, Shinji, Nakade, Hiromu, Habashita
Publikováno v:
Journal of medicinal chemistry. 60(23)
The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39f84e90dba8221686c7c9d410b02f32
https://pubmed.ncbi.nlm.nih.gov/29120624
https://pubmed.ncbi.nlm.nih.gov/29120624
Publikováno v:
Plantcell physiology. 58(12)
Rice production depends on water availability and carbon fixation by photosynthesis. Therefore, optimal control of stomata, which regulate leaf transpiration and CO2 absorption, is important for high productivity. SLOW ANION CHANNEL-ASSOCIATED 1 (SLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f365f7b07f8d897e24f56388b408212
https://pubmed.ncbi.nlm.nih.gov/29040767
https://pubmed.ncbi.nlm.nih.gov/29040767
Publikováno v:
Plant and Cell Physiology
CO2 acts as an environmental signal that regulates stomatal movements. High CO2 concentrations reduce stomatal aperture, whereas low concentrations trigger stomatal opening. In contrast to our advanced understanding of light and drought stress respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c9a5eb9a064bac6ad377ded76b2a3
https://doi.org/10.1093/pcp/pct145
https://doi.org/10.1093/pcp/pct145