Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kensei Komatsu"'
Publikováno v:
International Journal of Inflammation, Vol 2017 (2017)
Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. Nontypeable Haemophilus influenzae (NTHi) pathogen is responsible for approximately one-third
Externí odkaz:
https://doaj.org/article/867d2f6980964049a216ee18445c5d95
Autor:
Carla S Andrews, Masanori Miyata, Seiko Susuki-Miyata, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144840 (2015)
Airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) are characterized by excessive inflammation and are exacerbated by nontypeable Haemophilus influenzae (NTHi). Airway epithelial cells mount the initial innate immune resp
Externí odkaz:
https://doaj.org/article/62d5ba6ecb16485aae7891799e549dcf
Autor:
Wenzhuo Y Wang, Kensei Komatsu, Yuxian Huang, Jing Wu, Wenhong Zhang, Ji-Yun Lee, Masanori Miyata, Haidong Xu, Jian-Dong Li
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112516 (2014)
Nontypeable Haemophilus influenzae (NTHi), a Gram-negative bacterium, is the primary cause of otitis media in children and the exacerbation of chronic obstructive pulmonary disease in adults. A hallmark of both diseases is an overactive inflammatory
Externí odkaz:
https://doaj.org/article/9913441845e74347a82431b26e36708c
Autor:
Shingo Matsuyama, Kensei Komatsu, Byung-Cheol Lee, Yukihiro Tasaki, Masanori Miyata, Haidong Xu, Tsuyoshi Shuto, Hirofumi Kai, Jian-Dong Li
Publikováno v:
The Journal of Immunology. 209:1532-1544
Streptococcus pneumoniae is major cause of otitis media (OM) and life-threatening pneumonia. Overproduction of mucin, the major component of mucus, plays a critical role in the pathogenesis of both OM and pneumonia. However, the molecular mechanisms
Publikováno v:
The Journal of Immunology. 204:933-942
Otitis media (OM) is the most common bacterial infection in children. It remains a major health problem and a substantial socioeconomic burden. Streptococcus pneumoniae (S. pneumoniae) is one of the most common bacterial pathogens causing OM. Innate
Autor:
Shingo, Matsuyama, Kensei, Komatsu, Byung-Cheol, Lee, Yukihiro, Tasaki, Masanori, Miyata, Haidong, Xu, Tsuyoshi, Shuto, Hirofumi, Kai, Jian-Dong, Li
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(8)
Autor:
Jian Dong Li, Adegboyega K. Oyelere, Kensei Komatsu, Idris O. Raji, Lindsey C. Szymczak, Shaghayegh Fathi, Emily Janeira, Milan Mrksich, James R. Kornacki, Fatima Yadudu
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1202-1218
We herein disclose a series of compounds with potent inhibitory activities towards histone deacetylases (HDAC) and cyclooxygenases (COX). These compounds potently inhibited the growth of cancer cell lines consistent with their anti-COX and anti-HDAC
Autor:
Jian Dong Li, Kensei Komatsu
Publikováno v:
Cell hostmicrobe. 25(4)
Since the inner ear is an important but sensitive organ of hearing, bacteria-driven immune responses must be tightly controlled. In this issue of Cell Host & Microbe, Jung et al. (2019) demonstrate that cleaved cochlin plays a dual role to trap bacte
Autor:
Shyan Vijayasekaran, Arwa Kurabi, Stéphanie Val, Diego Preciado, Jian Dong Li, Kensei Komatsu, Ann Hermansson, Gustavo Nino, Oren Ziv
Publikováno v:
Int J Pediatr Otorhinolaryngol
Objectives To update the medical literature on recent large-scale studies employing bioinformatics data analysis tools in otitis media (OM) disease models with a principal focus on developments in the past 5 years. Data sources Pubmed indexed peer-re
Publikováno v:
International Journal of Inflammation
International Journal of Inflammation, Vol 2017 (2017)
International Journal of Inflammation, Vol 2017 (2017)
Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. NontypeableHaemophilus influenzae(NTHi) pathogen is responsible for approximately one-third of