Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kenolisa C. Onwueme"'
Autor:
Clifford E. Soll, Luis E. N. Quadri, Sivagami Sundaram Chavadi, Uthamaphani R. Edupuganti, Delphi Chatterjee, Jeff Jerome, Kenolisa C. Onwueme
Publikováno v:
Microbiology. 158:1379-1387
Phenolic glycolipids (PGLs) are non-covalently bound components of the outer membrane of many clinically relevant mycobacterial pathogens, and play important roles in pathogen biology. We report a mutational analysis that conclusively demonstrates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82a5fc5c7aa052849fc204620d7051d
https://doi.org/10.1099/mic.0.057869-0
https://doi.org/10.1099/mic.0.057869-0
Publikováno v:
Progress in Lipid Research. 44:259-302
Recent advances in the study of mycobacterial lipids indicate that the class of outer membrane lipids known as dimycocerosate esters (DIMs) are major virulence factors of clinically relevant mycobacteria including Mycobacterium tuberculosis and Mycob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1298ba2d0bd80005ff43f4f2533368ba
https://doi.org/10.1016/j.plipres.2005.07.001
https://doi.org/10.1016/j.plipres.2005.07.001
Autor:
Christopher D. Lima, Julian A. Ferreras, Kenolisa C. Onwueme, Luis E. N. Quadri, John A. Buglino
Publikováno v:
Proceedings of the National Academy of Sciences. 101:4608-4613
Mycobacterium tuberculosis ( Mt ) produces complex virulence-enhancing lipids with scaffolds consisting of phthiocerol and phthiodiolone dimycocerosate esters (PDIMs). Sequence analysis suggested that PapA5, a so-called polyketide-associated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40edba0e65b5b12f31f34ebca336a653
https://doi.org/10.1073/pnas.0306928101
https://doi.org/10.1073/pnas.0306928101
Diacyl phthiocerol esters and their congeners are mycobacterial virulence factors. The biosynthesis of these complex lipids remains poorly understood. Insight into their biosynthesis will aid the development of rationally designed drugs that inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da72d53c2afa7c0227dd7402da17e0a
https://europepmc.org/articles/PMC1169502/
https://europepmc.org/articles/PMC1169502/
Autor:
Christopher D. Lima, Kenolisa C. Onwueme, John A. Buglino, Julian A. Ferreras, Luis E. N. Quadri
Publikováno v:
The Journal of biological chemistry. 279(29)
Polyketide-associated protein A5 (PapA5) is an acyltransferase that is involved in production of phthiocerol and phthiodiolone dimycocerosate esters, a class of virulence-enhancing lipids produced by Mycobacterium tuberculosis. Structural analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8bf0cbfa87b0d3589dff1c875d1483
https://pubmed.ncbi.nlm.nih.gov/15123643
https://pubmed.ncbi.nlm.nih.gov/15123643
Publikováno v:
Science (New York, N.Y.). 301(5639)
Antibiotic self-resistance mechanisms, which include drug elimination, drug modification, target modification, and drug sequestration, contribute substantially to the growing problem of antibiotic resistance among pathogenic bacteria. Enediynes are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad015684f6478c4e65ef60caf63e427
https://pubmed.ncbi.nlm.nih.gov/12970566
https://pubmed.ncbi.nlm.nih.gov/12970566
Autor:
Jon S. Thorson, Eric L. Sievers, Joachim Ahlert, Kenolisa C. Onwueme, Mark Ruppen, Ross E. Whitwam, Erica M. Shepard
Publikováno v:
Current pharmaceutical design. 6(18)
The enediyne antitumor antibiotics are appreciated for their novel molecular architecture, their remarkable biological activity and their fascinating mode of action and many have spawned considerable interest as anticancer agents in the pharmaceutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033ed50c9b626d91c55dc8c1e0c76540
https://pubmed.ncbi.nlm.nih.gov/11102565
https://pubmed.ncbi.nlm.nih.gov/11102565