Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kenny Simmen"'
Autor:
Katie Amssoms, Philip A Born, Max Beugeling, Ben De Clerck, Ellen Van Gulck, Wouter L J Hinrichs, Henderik W Frijlink, Niels Grasmeijer, Guenter Kraus, Roger Sutmuller, Kenny Simmen, Lieven Baert
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202961 (2018)
A single-injection vaccine formulation that provides for both a prime and a boost immunization would have various advantages over a multiple-injection regime. For such a vaccine formulation, it is essential that the booster dose is released after a c
Externí odkaz:
https://doaj.org/article/39d9cf7d09974343b19898981fbcf509
Autor:
Olivia Goethals, Suzanne J. F. Kaptein, Bart Kesteleyn, Jean-François Bonfanti, Liesbeth Van Wesenbeeck, Dorothée Bardiot, Ernst J. Verschoor, Babs E. Verstrepen, Zahra Fagrouch, J. Robert Putnak, Dominik Kiemel, Oliver Ackaert, Roel Straetemans, Sophie Lachau-Durand, Peggy Geluykens, Marjolein Crabbe, Kim Thys, Bart Stoops, Oliver Lenz, Lotke Tambuyzer, Sandra De Meyer, Kai Dallmeier, Michael K. McCracken, Gregory D. Gromowski, Wiriya Rutvisuttinunt, Richard G. Jarman, Nicos Karasavvas, Franck Touret, Gilles Querat, Xavier de Lamballerie, Laurent Chatel-Chaix, Gregg N. Milligan, David W. C. Beasley, Nigel Bourne, Alan D. T. Barrett, Arnaud Marchand, Tim H. M. Jonckers, Pierre Raboisson, Kenny Simmen, Patrick Chaltin, Ralf Bartenschlager, Willy M. Bogers, Johan Neyts, Marnix Van Loock
Publikováno v:
Nature. 615:678-686
Dengue is a major health threat and the number of symptomatic infections caused by the four dengue serotypes is estimated to be 96 million1 with annually around 10,000 deaths2. However, no antiviral drugs are available for the treatment or prophylaxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8c0a4183f19bf33ac0d110d21b457f
https://doi.org/10.1038/s41586-023-05790-6
https://doi.org/10.1038/s41586-023-05790-6
Autor:
Bart Rudolf Romanie Kesteleyn, Suzanne J.F. Kaptein, Xavier de Lamballerie, Kenny Simmen, Arnaud Marchand, Jean-François Bonfanti, Max Münster, Laurent Chatel-Chaix, Marjolein Crabbe, Johan Neyts, Marnix Van Loock, Kai Dallmeier, Gilles Querat, Franck Touret, Kim Thys, Olivia Goethals, Dorothée Bardiot, Tim H. M. Jonckers, Pierre Jean-Marie Bernard Raboisson, Peggy Geluykens, Dominik Kiemel, Patrick Chaltin, Bart Stoops, Ralf Bartenschlager
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue1,2. There are no antiviral agents available to prevent or treat dengue. Here, we describe a highly potent dengu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0f695891d12a95fecae329bcce0424
https://lirias.kuleuven.be/handle/123456789/683277
https://lirias.kuleuven.be/handle/123456789/683277
Autor:
Suzanne J F, Kaptein, Olivia, Goethals, Dominik, Kiemel, Arnaud, Marchand, Bart, Kesteleyn, Jean-François, Bonfanti, Dorothée, Bardiot, Bart, Stoops, Tim H M, Jonckers, Kai, Dallmeier, Peggy, Geluykens, Kim, Thys, Marjolein, Crabbe, Laurent, Chatel-Chaix, Max, Münster, Gilles, Querat, Franck, Touret, Xavier, de Lamballerie, Pierre, Raboisson, Kenny, Simmen, Patrick, Chaltin, Ralf, Bartenschlager, Marnix, Van Loock, Johan, Neyts
Publikováno v:
Nature. 598(7881)
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4e1de640eac35dd21665b2d7bca5ffa
https://pubmed.ncbi.nlm.nih.gov/34697477
https://pubmed.ncbi.nlm.nih.gov/34697477
Autor:
Leen Vijgen, Lotke Tambuyzer, Bart Stoops, Sophie Lachau-Durand, Abdellah Tahri, Laurent Leclercq, Tse-I Lin, Jan Snoeys, Kenny Simmen, Jan Martin Berke, Tim H. M. Jonckers, Pierre Jean-Marie Bernard Raboisson
Publikováno v:
Journal of Medicinal Chemistry. 59:5790-5798
JNJ-54257099 (9) is a novel cyclic phosphate ester derivative that belongs to the class of 2′-deoxy-2′-spirooxetane uridine nucleotide prodrugs which are known as inhibitors of the HCV NS5B RNA-dependent RNA polymerase (RdRp). In the Huh-7 HCV ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f88621605dec048482d1cbd2ed84b9
https://doi.org/10.1021/acs.jmedchem.6b00382
https://doi.org/10.1021/acs.jmedchem.6b00382
Autor:
Maxwell D. Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Katie Amssoms, Stefaan Last, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Origène Nyanguile, Kenny Simmen, Pieter Van Remoortere, Pierre Raboisson, Sandrine Vendeville
Publikováno v:
Journal of Medicinal Chemistry. 57:1880-1892
Structure-based macrocyclization of a 6-carboxylic acid indole chemotype has yielded potent and selective finger-loop inhibitors of the hepatitis C virus (HCV) NS5B polymerase. Lead optimization in conjunction with in vivo evaluation in rats identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a739d81f60a1fc5d33b63d73ddc9a32b
https://doi.org/10.1021/jm401396p
https://doi.org/10.1021/jm401396p
Autor:
Tim H M, Jonckers, Abdellah, Tahri, Leen, Vijgen, Jan Martin, Berke, Sophie, Lachau-Durand, Bart, Stoops, Jan, Snoeys, Laurent, Leclercq, Lotke, Tambuyzer, Tse-I, Lin, Kenny, Simmen, Pierre, Raboisson
Publikováno v:
Journal of medicinal chemistry. 59(12)
JNJ-54257099 (9) is a novel cyclic phosphate ester derivative that belongs to the class of 2'-deoxy-2'-spirooxetane uridine nucleotide prodrugs which are known as inhibitors of the HCV NS5B RNA-dependent RNA polymerase (RdRp). In the Huh-7 HCV genoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0f1ca2a2623718cfaba29ad5b0f010b
https://pubmed.ncbi.nlm.nih.gov/27181575
https://pubmed.ncbi.nlm.nih.gov/27181575
Autor:
Sandrine Vendeville, Tse-I. Lin, Lili Hu, Abdellah Tahri, David McGowan, Maxwell D. Cummings, Katie Amssoms, Maxime Canard, Stefaan Last, Iris Van den Steen, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Kristof Van Emelen, Origène Nyanguile, Kenny Simmen, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4437-4443
Optimization of a novel series of macrocyclic indole-based inhibitors of the HCV NS5b polymerase targeting the finger loop domain led to the discovery of lead compounds exhibiting improved potency in cellular assays and superior pharmacokinetic profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdda9d43e14137e73732d76cab0062d
https://doi.org/10.1016/j.bmcl.2012.04.113
https://doi.org/10.1016/j.bmcl.2012.04.113
Autor:
Guenter Kraus, Philip A. Born, Kenny Simmen, Lieven Baert, Katie Amssoms, Ben De Clerck, Max Beugeling, Roger Paulus Maria Sutmuller, Ellen Van Gulck, Henderik W. Frijlink, Wouter L. J. Hinrichs, Niels Grasmeijer
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202961 (2018)
PLoS ONE, 13(8):0202961. PUBLIC LIBRARY SCIENCE
PLoS ONE, 13(8):0202961. PUBLIC LIBRARY SCIENCE
A single-injection vaccine formulation that provides for both a prime and a boost immunization would have various advantages over a multiple-injection regime. For such a vaccine formulation, it is essential that the booster dose is released after a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3317e98f4d0816505cb1bb74632ec757
https://doi.org/10.1371/journal.pone.0202961
https://doi.org/10.1371/journal.pone.0202961
Autor:
Koen Vandyck, Maxwell D. Cummings, Origène Nyanguile, Carlo W. Boutton, Sandrine Vendeville, David McGowan, Benoit Devogelaere, Katie Amssoms, Stefaan Last, Klara Rombauts, Abdellah Tahri, Pedro Lory, Lili Hu, Derek A. Beauchamp, Kenny Simmen, Pierre Raboisson
Publikováno v:
Journal of Medicinal Chemistry. 52:4099-4102
HCV NS5B polymerase, an essential and virus-specific enzyme, is an important target for drug discovery. Using structure-based design, we optimized a 1,5-benzodiazepine NS5B polymerase inhibitor chemotype into a new sulfone-containing scaffold. The de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93aec71e21a0196331ac1b9f5da18a7
https://doi.org/10.1021/jm9005548
https://doi.org/10.1021/jm9005548